Lisdexamfetamine
Aliases: Vyvanse, Elvanse, Tyvense, Lisdextroamphetamine, lisdextroamfetamine, lisdexamphetamine
Categories
Summary
Lisdexamfetamine is a prodrug that is inactive until enzymatically converted to dextroamphetamine by red blood cells. This design provides extended-release effects lasting 10-14 hours and theoretically reduces abuse potential, as insufflation or injection does not accelerate onset. Approved for ADHD in adults and children 6+ years, and for binge eating disorder in adults. Use caution with cardiovascular conditions and avoid combinations with MAOIs or other stimulants.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-30mg | 30-50mg | 50-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 1-2 hrs | 30-60 min | 3-5 hrs | 4-6 hrs | 2-6 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Cross-tolerance
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
Negative
- Increased Heart Rate
- Dry Mouth
- Insomnia
- Increased Blood Pressure
- Nausea
- Increased heart rate
- Sedation
Positive
- Focus Enhancement
- Motivation Enhancement
- Cognitive Euphoria
- Wakefulness
- Analysis Enhancement
- Euphoria
Negative
- Anxiety
- Thought deceleration
- Thought Acceleration
- Time Distortion
Positive
- Increased libido
- Increased music appreciation
Negative
- Appetite Suppression
- Dehydration
- Light sensitivity
- Appetite suppression
- Disinhibition
- Internal hallucinations
- Dulled perception
- Auditory hallucinations