Lisdexamfetamine
Aliases: Vyvanse, Elvanse, Tyvense, Lisdextroamphetamine, lisdextroamfetamine, lisdexamphetamine
Summary
Lisdexamfetamine is a prodrug that is inactive until enzymatically converted to dextroamphetamine by red blood cells. This design provides extended-release effects lasting 10-14 hours and theoretically reduces abuse potential, as insufflation or injection does not accelerate onset. Approved for ADHD in adults and children 6+ years, and for binge eating disorder in adults.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-30mg | 30-50mg | 50-100mg | 100mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 1-2 hrs | 30-60 min | 3-5 hrs | 4-6 hrs |
Effect Profile
51 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 51 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong stimulation, euphoria, focus, and anxiety/jitters
Tolerance
Tolerance Decay
Clinical and community data indicate noticeable tolerance with repeated daily dosing within days, and partial reversal after several weeks of abstinence. Quantitative values are heuristic for harm‑reduction planning, not prescriptive dosing guidance.
Cross-Tolerances
Effects
Aggregated from 51 Erowid experience reports