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    Loprazolam molecular structure

    Loprazolam Stats & Data

    Depressant Benzodiazepine
    Dormonoct
    NPS DataHub
    MW464.91
    FormulaC23H21ClN6O3
    CAS61197-73-7
    IUPAC(2''Z'')-6-(2-Chlorophenyl)-2-[(4-methyl-1-piperazinyl)methylene]-8-nitro-2,4-dihydro-1''H''-imidazo[1,2-''a''][1,4]benzodiazepin-1-one
    SMILESCN1CCN(CC1)C=C1N=C2CN=C(c3ccccc3Cl)c3cc(N(=O)=O)ccc3N2C1=O
    InChIKeyUTEFBSAVJNEPTR-RGEXLXHISA-N
    2020/3. Benzodiazepine; 2021/3. Benzodiazepine; 2022/3. Benzodiazepine
    Chemical Class Benzodiazepine
    Psychoactive Class Depressant

    Pharmacology

    DrugBank

    Description

    Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent nocturnal awakenings. Loprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug including dependence and withdrawal symptoms. It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. It is not an FDA-approved drug.

    Effect Profile

    Curated
    Benzodiazepine 7.6

    Strong euphoria and anxiolysis with mild sedation, low cognitive impairment

    Anxiolysis×3
    8
    Sedation / Relaxation×2
    5
    Motor / Cognitive Impairment×1
    1
    Euphoria / Mood Lift×1
    10
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Loprazolam

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d
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