Summary
In vitro transporter panels show MD-PiHP to be a potent DAT/NET blocker with ~10-fold selectivity over SERT, sitting pharmacologically between ฮฑ-PiHP and MDPHP. User reports indicate functional stimulation at 5-15 mg insufflated but marked vasoconstriction, bruxism and body-load over 40 mg. Vaping the HCl salt is heat-sensitive: freebasing or very low flame/oil-burner technique is essential to avoid pyrolysis. Oral dosing produces a flatter, long-tail stimulation (up to 8-10 hours wakefulness) that many find more manageable. Binge patterns exceeding 500 mg/24 hours have precipitated stimulant psychosis with auditory hallucinations, paranoia and formication; strict session caps (under 100 mg/day) and 48-hour recovery windows are strongly advised.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Insufflated | 1-3 min | 5-15 min | 30 min | 1-3 hrs | 2-12 hrs |
| Oral / Sublingual | 15-30 min | 30-60 min | 1-3 hrs | 2-4 hrs | 4-12 hrs |
| Vaporized / Smoked (Freebase) | 1-2 min | 1-5 min | 15 min | 1-2 hrs | 2-12 hrs |
| Rectal | 5-15 min | 15-30 min | 1-2 hrs | 1-3 hrs | 2-12 hrs |
| Intravenous | 1-2 min | 1-3 min | 15 min | 1-2 hrs | 2-12 hrs |
Tolerance
Effects
- Stimulation
- Physical euphoria
- Teeth grinding
- Nystagmus
- Vasoconstriction
- Increased heart rate
- Increased perspiration
- Increased blood pressure
- Insomnia
- Sweating
- Euphoria
- Focus enhancement
- Motivation enhancement
- Wakefulness
- Cognitive euphoria
- Compulsive redosing
- Anxiety
- Paranoia
- Thought acceleration
- Time distortion
- Increased libido
- Increased music appreciation
- Tactile enhancement
- Disinhibition
- Appetite suppression
- Light sensitivity
- Dehydration
- Appetite Suppression
- Vibrating vision
- Increase sexuality