MD-PiHP
Aliases: 3,4-methylenedioxy-pihp
Summary
In vitro transporter panels show MD-PiHP to be a potent DAT/NET blocker with ~10-fold selectivity over SERT, sitting pharmacologically between ฮฑ-PiHP and MDPHP. User reports indicate functional stimulation at 5-15 mg insufflated but marked vasoconstriction, bruxism and body-load over 40 mg. Vaping the HCl salt is heat-sensitive: freebasing or very low flame/oil-burner technique is essential to avoid pyrolysis.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Insufflated | 1-3 min | 5-15 min | 30 min | 1-3 hrs |
| Oral / Sublingual | 15-30 min | 30-60 min | 1-3 hrs | 2-4 hrs |
| Vaporized / Smoked (Freebase) | 1-2 min | 1-5 min | 15 min | 1-2 hrs |
| Rectal | 5-15 min | 15-30 min | 1-2 hrs | 1-3 hrs |
| Intravenous | 1-2 min | 1-3 min | 15 min | 1-2 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
6.1
Strong
6/10
Strong euphoria and anxiety/jitters with moderate focus, mild stimulation
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
10
physical euphoria
euphoria
cognitive euphoria
motivation enhancement
Focus / Productivity
×2
7
focus enhancement
motivation enhancement
thought acceleration
Anxiety / Jitters
×1
10
anxiety
paranoia
teeth grinding
increased heart rate
vasoconstriction
sweating
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3โ7 days for acute; 1โ3 weeks for full reset
Tolerance Decay
Full tolerance
12h
Half tolerance
3d
Baseline
~14d
Model inferred from binge/abstinence patterns seen with MDPV/MDPHP; exact values are illustrative for planning rest periods, not clinical PK.
Cross-Tolerances
Effects
Positive
- Stimulation
- Physical euphoria
Negative
- Teeth grinding
- Nystagmus
- Vasoconstriction
- Increased heart rate
- Increased perspiration
- Increased blood pressure
- Insomnia
- Sweating
Positive
- Euphoria
- Focus enhancement
- Motivation enhancement
- Wakefulness
- Cognitive euphoria
Negative
- Compulsive redosing
- Anxiety
- Paranoia
- Thought acceleration
- Time distortion
Positive
- Increased libido
- Increased music appreciation
- Tactile enhancement
Negative
- Disinhibition
- Appetite suppression
- Light sensitivity
- Dehydration
- Appetite Suppression
- Vibrating vision
- Increase sexuality
Combinations
MD-PiHP's nerd page
Pharmacology, chemical data, effect profiles, and more
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