MD-PiHP
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 6 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 6 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 3,4-methylenedioxy-pihp
Summary
MD-PiHP (3,4-methylenedioxy-PiHP) is a synthetic cathinone and pyrrolidine stimulant sold as a research chemical. In vitro transporter panels show it to be a potent DAT/NET blocker with ~10-fold selectivity over SERT, sitting pharmacologically between alpha-PiHP and MDPHP. User reports indicate functional stimulation at 5-15 mg insufflated, but marked vasoconstriction, bruxism and body-load over 40 mg. Vaping the HCl salt is heat-sensitive: freebasing or a very low flame/oil-burner technique is essential to avoid pyrolysis.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 2-10mg | 10-30mg | 30-45mg | 45mg+ |
| Oral | 5-20mg | 20-50mg | 50-80mg | 80mg+ |
| Sublingual | 5-15mg | 15-40mg | 40-70mg | 70mg+ |
| Vaporized | 1-5mg | 5-20mg | 20-40mg | 40mg+ |
| Rectal | 3-10mg | 10-25mg | 25-40mg | 40mg+ |
| Intravenous | 1-5mg | 5-15mg | 15-30mg | 30mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Insufflated | 1-3 min | 0.5-2 hrs | 1-3 hrs | 3-6 hrs |
| Oral | 15-30 min | 0.5-2 hrs | 1-3 hrs | 3-6 hrs |
| Sublingual | - | 0.5-2 hrs | 1-3 hrs | 3-6 hrs |
| Vaporized | - | 0.5-2 hrs | 1-3 hrs | 3-6 hrs |
| Rectal | - | 0.5-2 hrs | 1-3 hrs | 3-6 hrs |
| Intravenous | - | 0.5-2 hrs | 1-3 hrs | 3-6 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria and anxiety/jitters with moderate focus, mild stimulation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Model inferred from binge/abstinence patterns seen with MDPV/MDPHP; exact values are illustrative for planning rest periods, not clinical PK.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Teeth grinding
- Nystagmus
- Vasoconstriction
- Increased heart rate
- Increased perspiration
- Increased blood pressure
- Insomnia
- Sweating
- Euphoria
- Focus enhancement
- Motivation enhancement
- Wakefulness
- Cognitive euphoria
- Compulsive redosing
- Anxiety
- Paranoia
- Thought acceleration
- Time distortion
- Increased libido
- Increased music appreciation
- Tactile enhancement
- Disinhibition
- Appetite suppression
- Light sensitivity
- Dehydration
- Appetite Suppression
- Vibrating vision
- Increase sexuality
Combinations
Cross-Check MD-PiHP with another substanceHelpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for MD-PiHP? Let us know. Reports are reviewed by moderators — this is not posted publicly.