MDAI - Substance Search

Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

5,6-Methylenedioxy-2-aminoindane (also known as MDAI) is a lesser-known novel entactogen substance of the aminoindane class. It acts as a putatively non-neurotoxic and highly selective serotonin releasing agent (SSRA) with neglible effects on dopamine and norepinephrine. MDAI was developed by the American medicinal chemist and pharmacologist David E.

Dose Information TheDrug.Wiki TripSit PsychonautWiki

ROA	Light	Common	Strong	Heavy
Oral	40-100mg	100-175mg	175-300mg	300mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Oral	19-40 min	30-60 min	2-2.5 hrs	1-2 hrs	12-12 hrs	4-6 hrs

Effect Profile

67 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 41 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 4.0

Moderate 4/10

Strong body load and auditory effects with moderate visuals, low headspace

Visual Intensity ×3

6

colour enhancement

Headspace Depth ×3

2

Auditory Effects ×1

8

⚠ Body Load / Somatic Effects ×1

10

temperature regulation suppression nausea

Empathogen 9.7

Extreme 10/10

Strong empathy, euphoria, sensory enhancement, and stimulation

Empathy / Social Openness ×3

10

empathy enhancement sociability enhancement

Euphoria / Mood Elevation ×2

10

physical euphoria cognitive euphoria

Stimulation ×1

8

stimulation

Sensory Enhancement ×1

10

tactile enhancement colour enhancement

Stimulant 7.5

Intense 8/10

Strong euphoria and stimulation with moderate anxiety/jitters, mild focus

Stimulation / Energy ×3

9

stimulation alertness enhancement

Euphoria / Mood Lift ×2

10

physical euphoria cognitive euphoria

Focus / Productivity ×2

5

analysis enhancement

⚠ Anxiety / Jitters ×1

7

Based on reports from:

Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki MDAI The Drug Users Bible MDAI

Tolerance

Build-up develops rapidly after a single use

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 1h Half tolerance 10d Baseline ~14d

Effects Erowid Bluelight

Aggregated from 41 Erowid and 26 Bluelight experience reports

Positive Effects 48

Euphoria 65.7% 88%

Stimulation 50.7% 81%

Sociability Enhancement 50.0% 83%

Music Enhancement 41.8% 91%

Empathy 40.3% 87%

Sedation 38.8% 76%

Tactile Enhancement 32.8% 80%

Love 30.8% 84%

Body High 29.9% 78%

Libido Enhancement 26.9% 81%

Contentment 23.1% 82%

Color Enhancement 20.9% 82%

Joy 19.2% 85%

Focus Enhancement 16.5% 75%

Auditory Effects 11.9% 85%

Emotional Openness 11.5% 85%

Closed-Eye Visuals 10.5% 75%

Morphing 7.7% 82%

Communication Enhancement 7.7% 82%

Depersonalization 7.7% 85%

Adverse Effects 37

Insomnia 34.6% 82%

Anxiety 29.8% 82%

Confusion 26.8% 70%

Jaw Clenching 23.9% 80%

Nausea 19.4% 72%

Body Temperature Change 19.2% 75%

Increased Heart Rate 17.1% 70%

Visual Distortions 16.4% 95%

Dry Mouth 15.4% 82%

Dysphoria 15.4% 81%

Headache 13.4% 77%

Muscle Tension 8.9% 75%

Body Load 7.7% 75%

Temperature Sensitivity 7.7% 78%

Ataxia 7.7% 78%

Fear 7.7% 92%

Panic 7.7% 92%

Thought Loops 7.7% 80%

Dizziness 7.7% 80%

Ego Inflation 7.7% 75%

Combinations TripSit

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Helpful Links

📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 Bluelight 📖 The Drug Users Bible