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    Disclaimer
    πŸ§ͺ This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    MDAI Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 7 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical

    Aliases: Mindy, Sparkle

    Summary TheDrug.Wiki Erowid TripSit PsychonautWiki

    5,6-Methylenedioxy-2-aminoindane (also known as MDAI) is a lesser-known novel entactogen substance of the aminoindane class. It acts as a putatively non-neurotoxic and highly selective serotonin releasing agent (SSRA) with neglible effects on dopamine and norepinephrine. MDAI was developed by the American medicinal chemist and pharmacologist David E.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 40-100mg 100-175mg 175-300mg 300mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 19-40 min 30-60 min 2-2.5 hrs 1-2 hrs 12 hrs 4-6 hrs

    Effect Profile

    67 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 41 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 4.0
    Moderate 4/10

    Strong body load and auditory effects with moderate visuals, low headspace

    Visual Intensity ×3
    6
    colour enhancement
    Headspace Depth ×3
    2
    Auditory Effects ×1
    8
    Body Load / Somatic Effects ×1
    10
    temperature regulation suppression nausea
    Empathogen 9.7
    Extreme 10/10

    Strong empathy, euphoria, sensory enhancement, and stimulation

    Empathy / Social Openness ×3
    10
    empathy enhancement sociability enhancement
    Euphoria / Mood Elevation ×2
    10
    physical euphoria cognitive euphoria
    Stimulation ×1
    8
    stimulation
    Sensory Enhancement ×1
    10
    tactile enhancement colour enhancement
    Stimulant 7.5
    Intense 8/10

    Strong euphoria and stimulation with moderate anxiety/jitters, mild focus

    Stimulation / Energy ×3
    9
    stimulation alertness enhancement
    Euphoria / Mood Lift ×2
    10
    physical euphoria cognitive euphoria
    Focus / Productivity ×2
    5
    analysis enhancement
    Anxiety / Jitters ×1
    7

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7–14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Effects Erowid Bluelight

    Aggregated from 41 Erowid and 26 Bluelight experience reports

    Positive Effects 48

    Euphoria 65.7% 88%
    Stimulation 50.7% 81%
    Sociability Enhancement 50.0% 83%
    Music Enhancement 41.8% 91%
    Empathy 40.3% 87%
    Sedation 38.8% 76%
    Tactile Enhancement 32.8% 80%
    Love 30.8% 84%
    Body High 29.9% 78%
    Libido Enhancement 26.9% 81%
    Contentment 23.1% 82%
    Color Enhancement 20.9% 82%
    Joy 19.2% 85%
    Focus Enhancement 16.5% 75%
    Auditory Effects 11.9% 85%
    Emotional Openness 11.5% 85%
    Closed-Eye Visuals 10.5% 75%
    Morphing 7.7% 82%
    Communication Enhancement 7.7% 82%
    Depersonalization 7.7% 85%

    Adverse Effects 37

    Insomnia 34.6% 82%
    Anxiety 29.8% 82%
    Confusion 26.8% 70%
    Jaw Clenching 23.9% 80%
    Nausea 19.4% 72%
    Body Temperature Change 19.2% 75%
    Increased Heart Rate 17.1% 70%
    Visual Distortions 16.4% 95%
    Dry Mouth 15.4% 82%
    Dysphoria 15.4% 81%
    Headache 13.4% 77%
    Muscle Tension 8.9% 75%
    Body Load 7.7% 75%
    Temperature Sensitivity 7.7% 78%
    Ataxia 7.7% 78%
    Fear 7.7% 92%
    Panic 7.7% 92%
    Thought Loops 7.7% 80%
    Dizziness 7.7% 80%
    Ego Inflation 7.7% 75%

    Combinations TripSit

    Cross-Check MDAI with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 3 positive 3 neutral 2 cautionary visit
    Euphoria Without the Super Fast Rush positive exp #91871

    Previous experience MDMA, shrooms, kratom, weed. Had a normal size meal 3 hours prior to taking 200 gm MDAI swallowed as a bomb First effects noticed: 40 min lift in mood and a coming up warm feeling very nice and gentle unlike MDMA. 1hr 30 mins: Very good euphoric feeling similar to MDMA without the super fast rush.

    sonicbear · 200 mg oral / 100 mg oral
    Euphoria with a Poignant Come Down positive exp #87621

    We began our experience with around 0.05g, insufflated. We were quite drunk at this point. It creates a fantastic high, to be frank, although an alarmingly sexual one. One of us felt this way, the other not. Felt euphoric, but not wasted, despite clearly being wasted. High is much like MDMA, but more grounded.

    Pitchblende · 50 mg insufflated
    Not the Best positive exp #90472

    Bought some MDAI for a try as haven't done any chem since metherdrone not the best experience but here we go. 18.00 take 300mg orally don't feel anything for at least 2 hours start feeling slight euphoria nothing to get excited about.

    straighthead
    A Diary of My Solitary Misuse neutral exp #96974

    This is a diary of my solitary (mis)use of the research chemical MDAI. Part 1 - I purchased 1g of MDAI from an online vendor, not sure of reliability. A quasi-knowledgeable friend vouched for its purity. The powder was white with a slight goldish sheen and some easily crumbled crystalline structures.

    Nympha · oral
    Sexy Sexy Time neutral exp #98488

    Now I've pretty much tried it all.. MDMA, MDA, LSD, Mushrooms, various 2C-xx .. U name it pretty much.. I'm an occasional cannabis user, never got heavy into coke or opiates thou I've tried them a few times too.

    LoveandLaughter · 250 mg oral / 1 oral
    Yet Another Research Empathogen! neutral exp #99396

    The material in question was purchased from a Canadian distributor, and arrived as a dark grey-brown, fine powder. It had a smell like bitumen. The initial experiment was a bioassay, to be sure the delivered material provided expected results prior to taking a full dose.

    Refried Gluten · 150 mg oral / 100 mg oral
    A Midnight Bath in the Lake cautionary exp #86098

    WARNING: Some of the things I do here like redosing excessively or practicing physical activities may not suit every person. I recommend to be extremely cautious about them. So I finally got to try this new compound MDAI.

    Aster · 100 mg oral / 200 mg oral / 350 mg oral
    A Truly Awful Drug cautionary exp #88507

    Note: all times given here are approximate. I was not watching the clock, and although my time sense is normally good this doesn't hold true for all substances I have ingested. Previous drug experience: A wide variety of research chemicals of the stimulant and psychedelic varieties.

    Rugrat
    Bluelight 7 threads 1 positive 6 neutral visit
    Mdai First Time positive

    This is my first post, so please bare with me. Here my MDAI trip report. First, a little history, I’m experienced in the art of, weed, hash, opium (a wonderful time lady’s and gentlemen, in a NYC den over a whole weekend with friends) coke (I know I know, but it’s fun to rush rush to yayo sometimes) salvia devierum (β€˜w...

    scraped 2026-03-14
    Mdai Dose Unknown Beginnerish Great Saturday Bonding neutral

    HI there! So here is my story! I had purchased a product from a vendor (for details please private message) that stated it contained 98% pure MDAI; after waiting several days with anxiety fearing I may be arrested (as unsure as to the true legality of MDAI in my location) the product arrived.

    scraped 2026-03-14
    Mdai 1g Semi Experienced Horrible And Frightening neutral

    Hey this is my first post on here, lurked for abit but anyway this isn't the place for introductions. My trip occured on the Friday just gone (the 7th of May). So i bought 1 gram of MDAI from the internet as i felt like trying something new, i used to be quite a heavy weed smoker and took ecstasy too.

    scraped 2026-03-14
    Mdai 250mg First Time Very Good neutral

    info: Male, age 31, 65kg Previous experiences: MDMA, Charlie, Amphet (most types), ketamine, cannabis, some opiates. Dosage: MDAI 250mg (only) Location: In the bedroom, on the computer. Bought 1g of MDAI the other day from a reasonably well know vendor. It was marketed as MDAI Gold (fewer impurities apparently).

    scraped 2026-03-14
    Mdai 150mg First Time Just Had My First Dose Today neutral

    Just had my first dose today. Since it arrived before my 2-fa I thought it a good idea to take it in isolation to analyse effects. took 150 mgs apporx total weighed on my scales. Started slow with allergy test. Waited 20 mins, then kept taking 25 mg every 25 mins or so since wasnt experiencing anyhting prfound.

    scraped 2026-03-14
    Mdai 250mg First Time Unbelievable Antidepressant Action neutral

    Before I start, a short introduction. I am quite experienced with serotonergics like MDAI, and I also like to deeply study the science behind these compounds. This was however my first time taking this particular analogue of MDMA, called MDAI.

    scraped 2026-03-14
    Mdai 75mg Insufflated New Experience Bp Heart Rate And Body Temp Timeline neutral

    6 : 55 pm bp: 111/70 hr: 82 body temp: 36.5 c - 25mg insufflated - -interesting taste, pleasant in a way, didnt burn as much as expected t + 2 min -> experiencing slight temperature changes t + 3 min -> bitter drip starting to feel the compound, calming in a way, very little stimulation t + 4 min -> efects kick in almo...

    scraped 2026-03-14

    Bluelight Reference Guide Bluelight

    The Big & Dandy MDAI Thread: Second Dose

    The Big & Dandy MDAI Thread Wikipedia MDAI page Previous thread Carry on EDIT: Doh! I'll see if I can get the post on the right page shortly. I may have to get a man in though (Sorry to cosy up on you like this Ebola - quick fixes ftw) ***** Original Post ***** I yield moderately strong fx at ~125 mg.

    Read full thread on Bluelight β†’

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