MDMPEA - Substance Search

Summary TheDrug.Wiki

MDMPEA is an obscure research compound patented by Merck in 1956 as an antitussive but never marketed clinically. Animal studies showed only moderate cough-suppression efficacy. It is classified as Schedule I in the USA as a positional isomer of MDA, prohibiting all non-research human use.

Dose Information TheDrug.Wiki

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Comeup	Peak	Offset
Oral	10-30 min	10-20 min	20-40 min	30-60 min
Insufflated	3-10 min	5-15 min	20-40 min	30-60 min

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Empathogen 5.4

Moderate+ 5/10

Strong euphoria with moderate stimulation and sensory enhancement, low empathy

Empathy / Social Openness ×3

2

increased sociability

Euphoria / Mood Elevation ×2

9

physical euphoria euphoria cognitive euphoria

Stimulation ×1

7

stimulation wakefulness teeth grinding increased heart rate

Sensory Enhancement ×1

7

tactile enhancement color enhancement increased libido

Stimulant 5.1

Moderate+ 5/10

Strong euphoria and anxiety/jitters with mild stimulation, low focus

Stimulation / Energy ×3

5

stimulation wakefulness

Euphoria / Mood Lift ×2

10

physical euphoria euphoria cognitive euphoria motivation enhancement

Focus / Productivity ×2

3

motivation enhancement thought acceleration

⚠ Anxiety / Jitters ×1

10

anxiety increased heart rate teeth grinding jaw tension vasoconstriction

Based on reports from:

Erowid Experience Reports PsychonautWiki MDMPEA

Tolerance

Build-up develops rapidly after a single use (serotonergic psychedelic)

Reset 7–14 days for baseline

Tolerance Decay

Full tolerance 8h Half tolerance 3d Baseline ~14d

Acute tachyphylaxis and post‑use depletion are plausible with repeated dosing in one session; multi‑day spacing is prudent. Data quality is low/anecdotal.