MDMPEA
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Mk-71, Homarylamine, N-methylhomopiperonylamine
Summary
MDMPEA is an obscure research compound patented by Merck in 1956 as an antitussive but never marketed clinically. Animal studies showed only moderate cough-suppression efficacy. It is classified as Schedule I in the USA as a positional isomer of MDA, prohibiting all non-research human use.
Dose Information
| ROA | Threshold |
|---|---|
| Oral | 100mg |
| Insufflated | 50mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-30 min | 10-20 min | 20-40 min | 30-60 min | 1.17-2.5 hrs |
| Insufflated | 3-10 min | 5-15 min | 20-40 min | 30-60 min | 0.96-2.09 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong euphoria with moderate stimulation and sensory enhancement, low empathy
Strong euphoria and anxiety/jitters with mild stimulation, low focus
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track MDMPEA there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
MDMPEA Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 100 Insufflated dose (mg): threshold 50 Oral duration: onset 10-30m · come-up 10-20m · peak 20-40m · offset 0.5-1h · total 1.17-2.5h Insufflated duration: onset 3-10m · come-up 5-15m · peak 20-40m · offset 0.5-1h · total 0.96-2.09h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Acute tachyphylaxis and post‑use depletion are plausible with repeated dosing in one session; multi‑day spacing is prudent. Data quality is low/anecdotal.
Cross-Tolerances
Effects
- Stimulation
- Physical euphoria
- Increased heart rate
- Jaw tension
- Teeth grinding
- Pupil dilation
- Vasoconstriction
- Increased perspiration
- Insomnia
- Decreased appetite
- Euphoria
- Motivation enhancement
- Wakefulness
- Increased sociability
- Cognitive euphoria
- Anxiety
- Compulsive redosing
- Increased focus
- Time distortion
- Thought acceleration
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
- Color enhancement
- Pattern recognition enhancement
- Light sensitivity
- Dehydration
- Appetite suppression
- Disinhibition
Combinations
Cross-Check MDMPEA with another substanceHelpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for MDMPEA? Let us know. Reports are reviewed by moderators — this is not posted publicly.