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    Metaxalone Encyclopedic
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    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • PubChem toxicity data

    Aliases: Skelaxin

    Depressant

    Summary Erowid TripSit

    Metaxalone is a centrally acting skeletal-muscle relaxant, used to relieve pain and discomfort caused by muscle injuries.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 400-800mg 800-1600mg 1600-2400mg 2400mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 15-45 min 4-8 hrs 1-8 hrs 4-8 hrs

    Tolerance

    Build-up develops over 1–4 weeks of regular use
    Reset days to weeks depending on duration of use

    Tolerance Decay

    Full tolerance 3d Half tolerance 8d Baseline ~14d

    Effects Erowid

    Aggregated from 21 Erowid experience reports

    Positive Effects 8

    Anxiety Suppression 42.9% 70%
    Sedation 38.1% 70%
    Stimulation 19.0% 70%
    Focus Enhancement 19.0% 70%
    Euphoria 19.0% 70%
    Pain Relief 14.3% 70%
    Empathy 14.3% 70%
    Music Enhancement 14.3% 70%

    Adverse Effects 4

    Nausea 28.6% 70%
    Increased Heart Rate 23.8% 70%
    Sweating 14.3% 70%
    Confusion 14.3% 70%

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 8 reports 7 neutral 1 cautionary visit
    Anxiety Relief and a Pleasant Surprise neutral exp #77921

    For the past 2 years, I have been consistently prescribed oxycodone – in various forms – for a broken back, the subsequent surgery, and post-surgical pain. I have developed quite a tolerance as you might imagine, requiring over 200mg a day to alleviate the pain.

    Ivy Traveller · Metaxalone (Skelaxin) · 400 mg insufflated
    A Wonderful, Interesting Substance neutral exp #94533

    In my early teens I was prescribed a drug commonly known as Skelaxin, or Metaxalone, as a secondary treatment for the chronic anxiety I suffer. It worked fairly well; it did its job to the best of its ability, however due to my tendency to abuse the medications I was prescribed in the absence of marijuana or any of the...

    Schnezz · Metaxalone (Skelaxin)
    No Relief neutral exp #81466

    I have been on a lot of medications for a variety of issues, and suffer from anorexia nervosa. Recently I began getting knots in my muscles and spasms and went to visit the doctor. I asked to be put on a muscle relaxer to get some relief, and she prescribed me Skelaxin.

    soberqueen89
    Curiosity Leads to Interesting Experience neutral exp #98982

    After some consideration of various sites and pieces of information, I decided to try out insulfating 800mg of Skelaxin as a possible means to a body high. The idea had been previously raised by my boyfriend.

    Quasita · Metaxalone (Skelaxin) · 400 mg insufflated / 400 mg oral
    Not-so-Relaxin neutral exp #68168

    I am an experienced drug user having tried LSD, XTC, cocaine. speed, opiates, and various pharmaceuticals and herbal drugs. I try not to take any one substance for a long period of time and I am interested in trying new chemicals to see what experiences are possible.

    oversoul · Metaxalone (Skelaxin) · 1600 mg oral
    Not Worth the Time neutral exp #73566

    I came across a bottle from a friend, I didn't find too much info on experience so I started out small. On 8/19/08 at 2pm I took 1/2 pill, I took the other half one hour later at 3pm. 3pm I felt slightly light headed and a little excited, mostly from the new experience.

    E1983 · Metaxalone (Skelaxin) · 400 mg oral / 400 mg oral / 800 mg oral / 2400 mg oral
    A Last Resort neutral exp #19406

    I recently had a muscle strain in my lower back from working. I got a script for the muscle relaxer Skelaxin. I thought, you know--a pill is a pill, so at first I snorted one tab. I didn't expirence any kind of a high or buzz, but I was slightly relaxed.

    Chrissy · Metaxalone (Skelaxin) · 2500 mg oral
    Freaked Out cautionary exp #101068

    I have been having some problems with head and neck pain for a while, so my doctor prescribed me Flexeril (Cyclobenzaprine) the other day. I remember using some muscle relaxant a few years ago and it was reasonably enjoyable. Nothing over the top. Just a calm experience.

    bob
    Bluelight 1 thread 1 neutral visit
    Skelaxin 1 6 G First Time Relaxing With Skelaxin neutral

    So mother has some of these 800mg Skelaxin's laying around. Supposedly to just relax muscles and chill twitches and spasms. I read up, and there does not seem to be a ton of recreational value. I found a couple people claiming it potentiates opiates. So I set out to explore. Took 2.

    scraped 2026-03-14

    Pill Identifiers

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    Helpful Links

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