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    Disclaimer
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Methyprylon Encyclopedic
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    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • 17 combo interactions documented
    • PubChem toxicity data
    • classified Tentative

    Aliases: Noludar

    Depressant Benzodiazepine

    Summary TripSit

    Sedative of the pipeidinedone family. Was used for treating insomnia, yet is rarely used today due to substances with fewer side effects, such as benzodiazepines.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 150-200mg 200-300mg 300mg 300mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Peak After Effects Total
    Oral 6-12 hrs 1-16 hrs 6-12 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 4.7
    Moderate+ 5/10

    Strong euphoria with low anxiolysis, sedation, and cognitive impairment

    Anxiolysis ×3
    3
    reduced anxiety
    Sedation / Relaxation ×2
    3
    sedation
    ⚠ Motor / Cognitive Impairment ×1
    2
    confusion
    Euphoria / Mood Lift ×1
    10
    euphoria cognitive euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Methyprylon
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Effects

    Positive
    • Stimulation
    Negative
    • Motor impairment
    • Increased heart rate
    • Pupil dilation
    • Insomnia
    • Nausea
    • Vasoconstriction
    • Restlessness
    Neutral
    • Sedation
    • Decreased appetite
    Positive
    • Reduced anxiety
    • Euphoria
    • Cognitive euphoria
    • Wakefulness
    • Empathy
    Negative
    • Anxiety
    • Confusion
    • Compulsive redosing
    Neutral
    • Time distortion
    • Talkativeness
    Positive
    • Increased music appreciation
    • Color enhancement
    • Tactile enhancement
    • Brightened colour
    Negative
    • Light sensitivity
    • Appetite suppression
    • Dehydration
    • Disinhibition
    Neutral
    • Dulled perception
    • Drifting

    Combinations TripSit

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    Helpful Links

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