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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Metizolam

    Aliases: Metiz, Desmethyletizolam

    Depressant Research-chemical Benzodiazepine

    Summary TheDrug.Wiki TripSit PsychonautWiki

    Metizolam is a research chemical with very little history of human use and minimal scientific study. It was patented in 1995 but never marketed as a medication. Due to its extreme potency, volumetric liquid dosing is strongly recommended to ensure accurate administration.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 1-2mg 2-4mg 4-6mg 6mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-90 min 30 min 3-6 hrs 10-30 hrs 4-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.9
    Intense 8/10

    Strong anxiolysis and euphoria with moderate cognitive impairment and sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation emotion suppression
    Sedation / Relaxation ×2
    6
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    7
    motor control loss amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    10
    cognitive euphoria physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Metizolam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Effects TheDrug.Wiki TripSit

    Positive
    • Muscle Relaxation
    • Muscle relaxation
    • Physical euphoria
    • Anxiolytic
    Negative
    • Respiratory Depression
    • Motor impairment
    • Respiratory depression
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    Positive
    • Anxiety Suppression
    • Dream Potentiation
    • Cognitive Euphoria
    Negative
    • Motor Control Loss
    • Amnesia
    • Dizziness
    • Thought Deceleration
    • Emotion Suppression
    • Delusions of Sobriety
    • Compulsive Redosing
    • Analysis Suppression
    • Delusions
    • Information processing suppression
    Positive
    • Increased libido
    • Appetite enhancement
    • Increased music appreciation
    Negative
    • Disinhibition
    • Visual acuity suppression
    • Acuity suppression
    • Dehydration
    • Light sensitivity
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Metizolam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki