Summary
Benzodiazepine derivative that has been trialed for anxiety and was found to be effective for anxiety at one week week follow-ups yet after three weeks it had lost its therapeutic anxiolytic properties and becoming no more effective than placebo.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.25-0.5mg | 0.5-1.5mg | 1.5-2mg | 2-3mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | After Effects | Total |
|---|---|---|---|---|
| Oral | 5-45 min | 4.0-8.0 hrs | 1.0-12.0 hrs | 240-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
Negative
- Motor impairment
- Increased heart rate
- Nausea
- Vasoconstriction
- Respiratory depression
- Teeth grinding
- Sedation
Positive
- Reduced anxiety
- Cognitive euphoria
- Euphoria
- Anxiety suppression
- Wakefulness
Negative
- Anxiety
- Compulsive redosing
- Dizziness
- Thought deceleration
- Time distortion
Positive
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
Negative
- Disinhibition
- Appetite suppression
- Dehydration
- Light sensitivity
- Double vision
- Dulled perception