Mexazolam Stats & Data
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DrugBankDescription
Mexazolam (CS-386) is a benzodiazepine indicated for the treatment of anxiety with or without psychoneurotic conditions. Mexazolam's structure is similar to that of other benzodiazepines such as oxazolam and cloxazolam. The use of benzodiazepines in the treatment of anxiety is generally a second line measure.
Mechanism of Action
Mexazolam is a benzodiazepine that binds to benzodiazepine-type receptors, inhibiting gamma-aminobutyric acid.
Metabolism
Mexazolam is rapidly metabolized to the active metabolites chloronordiazepam and chloroxazepam.
Absorption
The active metabolite chloronordiazepam has a Tmax of 1-2h.
Indication
Mexazolam is indicated for the treatment of anxiety with or without psychoneurotic conditions.
Half-life
Mexazolam follows a 2 compartment model with a first half life of 1.4h and a second half life of 76h.
Protein Binding
Mexazolam is >90% protein bound in plasma.
Elimination
Mexazolam is mainly eliminated in the bile and feces, with <10% eliminated as metabolites in the urine. >50% of a dose of mexazolam is eliminated as the metabolite chloroxazepam.
Effect Profile
CuratedStrong euphoria and anxiolysis with mild sedation, low cognitive impairment