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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Mexedrone

    Aliases: 4-mmeoc, 4-mmc-meo

    Stimulant Empathogen Research-chemical

    Summary TheDrug.Wiki TripSit PsychonautWiki

    Mexedrone is a research chemical with very little history of human use prior to 2015. It was marketed as a legal alternative to mephedrone but is reported to be approximately 10-20 times weaker in potency, requiring higher doses to achieve comparable effects. The substance has been associated with significant sedation rather than stimulation, distinguishing it from mephedrone.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 100-150mg 150-250mg 250-350mg 300mg+
    Insufflated 50-80mg 80-120mg 120-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 30-60 min 2-3 hrs 1-2 hrs 2-12 hrs 3.5-6 hrs
    Insufflated 5-20 min 1.5-2.5 hrs 1-2 hrs 2-12 hrs 2.6-4.8 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 5.0
    Moderate+ 5/10

    Strong sensory enhancement and euphoria with moderate stimulation

    Empathy / Social Openness ×3
    0
    Euphoria / Mood Elevation ×2
    9
    physical euphoria euphoria cognitive euphoria
    Stimulation ×1
    7
    stimulation wakefulness teeth grinding increased heart rate
    Sensory Enhancement ×1
    10
    tactile enhancement spontaneous tactile sensations increased libido
    Stimulant 5.1
    Moderate+ 5/10

    Strong euphoria and anxiety/jitters with mild stimulation, low focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    9
    physical euphoria euphoria cognitive euphoria
    Focus / Productivity ×2
    3
    thought acceleration
    ⚠ Anxiety / Jitters ×1
    8
    anxiety teeth grinding increased heart rate
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Mexedrone The Drug Users Bible Mexedrone
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1h Half tolerance 4d Baseline ~5d

    Effects TheDrug.Wiki TripSit

    Positive
    • Physical Euphoria
    • Spontaneous tactile sensations
    • Stimulation
    Negative
    • Increased Perspiration
    • Temperature Regulation Suppression
    • Teeth Grinding
    • Nystagmus
    • Increased heart rate
    • Pupil dilation
    Neutral
    • Sedation
    Positive
    • Euphoria
    • Thought Connectivity
    • Cognitive euphoria
    • Wakefulness
    Negative
    • Anxiety
    • Cognitive Fatigue
    • Depression
    • Irritability
    Neutral
    • Thought Acceleration
    • Thought acceleration
    Positive
    • Tactile Enhancement
    • Auditory Enhancement
    • Increased music appreciation
    • Tactile enhancement
    • Increased libido
    • Tracers
    Negative
    • Dehydration
    • Appetite suppression
    Neutral
    • Spontaneous Physical Sensations
    • Vibrating vision

    Combinations TripSit

    Mexedrone's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit 📖 The Drug Users Bible