Summary
Mexedrone is a research chemical with very little history of human use prior to 2015. It was marketed as a legal alternative to mephedrone but is reported to be approximately 10-20 times weaker in potency, requiring higher doses to achieve comparable effects. The substance has been associated with significant sedation rather than stimulation, distinguishing it from mephedrone. Legal status varies by jurisdiction; it is controlled in Sweden, Switzerland, Brazil, and the United Kingdom under blanket bans on cathinones or psychoactive substances. Users should employ accurate milligram scales and practice harm reduction.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 100-150mg | 150-250mg | 250-350mg | 300mg+ |
| Insufflated | 50-80mg | 80-120mg | 120-200mg | 200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 2-3 hrs | 1-2 hrs | 2-12 hrs | 240-0 min |
| Insufflated | 5-20 min | 1.5-2.5 hrs | 1-2 hrs | 2-12 hrs | 60-0 min |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Physical Euphoria
- Spontaneous tactile sensations
- Stimulation
Negative
- Increased Perspiration
- Temperature Regulation Suppression
- Teeth Grinding
- Nystagmus
- Increased heart rate
- Pupil dilation
- Sedation
Positive
- Euphoria
- Thought Connectivity
- Cognitive euphoria
- Wakefulness
Negative
- Anxiety
- Cognitive Fatigue
- Depression
- Irritability
- Thought Acceleration
- Thought acceleration
Positive
- Tactile Enhancement
- Auditory Enhancement
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
Negative
- Dehydration
- Appetite suppression
- Spontaneous Physical Sensations
- Vibrating vision