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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    MGM-15

    Aliases: M-p, Pseudo, Mitragynine pseudoindoxyl

    Categories

    Depressant Psychedelic Research-chemical Opioid
    MGM-15 structure

    Summary TheDrug.Wiki

    Preclinical studies show MGM-15 is approximately 15x (subcutaneous) and 50x (oral) more potent than morphine in rodent models, yet human anecdotal dosing clusters around 25-60 mg oral, roughly 2x the per-milligram potency of 7-hydroxymitragynine. This compound is a rearrangement product of 7-hydroxymitragynine with remarkable ฮผ-opioid receptor affinity (Ki 0.087 nM) and functions as a G-protein biased agonist with minimal ฮฒ-arrestin-2 recruitment, potentially explaining its reduced respiratory depression and tolerance development compared to morphine. The powder is tan-brown and sparingly soluble in water; volumetric dosing in 95% ethanol or PG:VG solutions is recommended. Duration exceeds that of 7-hydroxymitragynine and kratom leaf, with many users reporting 8-10 hour analgesia. Community harm-reduction recommends keeping 4 mg naloxone readily available and re-dosing every 20-30 minutes if respiratory depression re-emerges.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral (Toss And Wash / Capsules / Pressed Tabs) 20-45 min 30-60 min 1-3 hrs 3-5 hrs 12 hrs
    Sublingual (Powder Held Under Tongue) 10-20 min 20-40 min 1-3 hrs 3-5 hrs 12 hrs
    Insufflated (Rare; Not Recommended) 5-10 min 15-30 min 1-2.5 hrs 2-4 hrs 12 hrs
    Oral 20-30 min 30-60 min 1-3 hrs 1-2 hrs 1-4 hrs
    Sublingual 10-15 min 15-30 min 1-2 hrs 1-2 hrs 1-4 hrs

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7โ€“14 days for partial reset; full reset may take weeks โ€” tolerance loss greatly increases overdose risk

    Effects TheDrug.Wiki

    Positive
    • Physical euphoria
    • Pain relief
    • Muscle relaxation
    • Cough suppression
    • Stimulation
    Negative
    • Respiratory depression
    • Nausea
    Neutral
    • Sedation
    • Itchiness
    • Pupil constriction
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Euphoria
    • Relaxation
    • Wakefulness
    Negative
    • Constipation
    • Compulsive redosing
    • Anxiety
    • Dizziness
    Neutral
    • Time distortion
    Positive
    • Auditory enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    Neutral
    • Dulled perception
    • Drifting
    • Internal hallucination
    • Auditory hallucinations
    • Internal hallucinations
    • Perception of increased weight
    • Auditory distortion

    Combinations TripSit

    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– PsychonautWiki