MGM-15 - Substance Search

Summary TheDrug.Wiki

Preclinical studies show MGM-15 is approximately 15x (subcutaneous) and 50x (oral) more potent than morphine in rodent models, yet human anecdotal dosing clusters around 25-60 mg oral, roughly 2x the per-milligram potency of 7-hydroxymitragynine. This compound is a rearrangement product of 7-hydroxymitragynine with remarkable μ-opioid receptor affinity (Ki 0.087 nM) and functions as a G-protein biased agonist with minimal β-arrestin-2 recruitment, potentially explaining its reduced respiratory depression and tolerance development compared to morphine. The powder is tan-brown and sparingly soluble in water; volumetric dosing in 95% ethanol or PG:VG solutions is recommended.

Dose Information TheDrug.Wiki

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki

ROA	Onset	Comeup	Peak	Offset	After Effects
Oral (Toss And Wash / Capsules / Pressed Tabs)	20-45 min	30-60 min	1-3 hrs	3-5 hrs	12-12 hrs
Sublingual (Powder Held Under Tongue)	10-20 min	20-40 min	1-3 hrs	3-5 hrs	12-12 hrs
Insufflated (Rare; Not Recommended)	5-10 min	15-30 min	1-2.5 hrs	2-4 hrs	12-12 hrs
Oral	20-30 min	30-60 min	1-3 hrs	1-2 hrs	1-4 hrs
Sublingual	10-15 min	15-30 min	1-2 hrs	1-2 hrs	1-4 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Psychedelic 4.1

Moderate 4/10

Strong auditory effects with mild visuals, low body load and headspace

Visual Intensity ×3

4

internal hallucinations drifting

Headspace Depth ×3

1

time distortion

Auditory Effects ×1

10

auditory enhancement auditory hallucinations auditory distortion

⚠ Body Load / Somatic Effects ×1

2

nausea

Opioid 6.6

Strong+ 7/10

Strong euphoria with moderate sedation and itching/nausea, mild pain relief

Euphoria / Warmth ×3

9

physical euphoria cognitive euphoria euphoria

Analgesia ×2

4

pain relief

Sedation / Relaxation ×1

7

sedation relaxation muscle relaxation

⚠ Itching / Nausea ×1

6

nausea constipation

Based on reports from:

Erowid Experience Reports PsychonautWiki MGM-15

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 3d Half tolerance 5d Baseline ~21d

Opioid-class tolerance can develop quickly with daily use; users report ‘losing effect’ within days. Cross-tolerance with other opioids is expected but extent is uncertain. Very limited empirical data exist for MGM-15; estimates are extrapolated from opioid pharmacology and user reports. Data quality: anecdotal.

Cross-Tolerances

7-hydroxymitragynine

80%

mitragynine/kratom

50%

classical opioids (morphine, oxycodone, fentanyl)

70%

Effects TheDrug.Wiki

Positive

Physical euphoria
Pain relief
Muscle relaxation
Cough suppression
Stimulation

Negative

Respiratory depression
Nausea

Neutral

Sedation
Itchiness
Pupil constriction

Positive

Cognitive euphoria
Anxiety suppression
Euphoria
Relaxation
Wakefulness

Negative

Constipation
Compulsive redosing
Anxiety
Dizziness

Neutral

Time distortion

Positive

Auditory enhancement

Negative

Appetite suppression
Light sensitivity

Neutral

Dulled perception
Drifting
Internal hallucination
Auditory hallucinations
Internal hallucinations
Perception of increased weight
Auditory distortion

Combinations TripSit

MGM-15's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki