MGM-15
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Encyclopedic
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- 1 source
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- 3 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: M-p, Pseudo, Mitragynine pseudoindoxyl
Summary
MGM-15 (mitragynine pseudoindoxyl) is a research-chemical opioid derived from the kratom alkaloid mitragynine, formed as a rearrangement product of its active metabolite 7-hydroxymitragynine. It acts as a potent, G-protein-biased agonist at the ฮผ-opioid receptor (Ki โ 0.087 nM) with minimal ฮฒ-arrestin-2 recruitment โ a signalling profile linked in preclinical studies to less respiratory depression and slower tolerance build-up than morphine. Those animal studies place it roughly 15x (subcutaneous) to 50x (oral) more potent than morphine, while human anecdotal reports cluster around 25โ60 mg orally, about twice the per-milligram potency of 7-hydroxymitragynine. It is a tan-brown powder, sparingly soluble in water, so volumetric dosing in ethanol or PG/VG is advised.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-15mg | 15-40mg | 40-80mg | 80mg+ |
| Sublingual | 5-15mg | 15-40mg | 40-80mg | 80mg+ |
| Rectal | 5-12mg | 12-30mg | 30-60mg | 60mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-60 min | 1-3 hrs | 3-6 hrs | 6-12 hrs |
| Sublingual | - | 1-3 hrs | 3-6 hrs | 6-12 hrs |
| Rectal | 20-90 min | 1-3 hrs | 3-6 hrs | 6-12 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong auditory effects with mild visuals, low body load and headspace
Strong euphoria with moderate sedation and itching/nausea, mild pain relief
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Opioid-class tolerance can develop quickly with daily use; users report โlosing effectโ within days. Cross-tolerance with other opioids is expected but extent is uncertain. Very limited empirical data exist for MGM-15; estimates are extrapolated from opioid pharmacology and user reports. Data quality: anecdotal.
Cross-Tolerances
Effects
- Physical euphoria
- Pain relief
- Muscle relaxation
- Cough suppression
- Stimulation
- Respiratory depression
- Nausea
- Sedation
- Itchiness
- Pupil constriction
- Cognitive euphoria
- Anxiety suppression
- Euphoria
- Relaxation
- Wakefulness
- Constipation
- Compulsive redosing
- Anxiety
- Dizziness
- Time distortion
- Auditory enhancement
- Appetite suppression
- Light sensitivity
- Dulled perception
- Drifting
- Internal hallucination
- Auditory hallucinations
- Internal hallucinations
- Perception of increased weight
- Auditory distortion
Combinations
Cross-Check MGM-15 with another substanceHelpful Links
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