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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.
    ⚠ This substance has both stimulant and depressant properties, which can mask the effects of each other and increase the risk of overdose or cardiovascular complications.

    Mitragynine Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 19 combo interactions documented
    • dose data not in PW/TripSit (unverifiable)

    Aliases: 9-methoxycorynantheidine

    Depressant Stimulant Opioid

    Summary dose.wiki

    Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contribute to reduced respiratory depression risk compared to morphine. However, pure extracts carry significantly greater overdose risk than plant material due to the natural nausea ceiling in leaf powder.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Dose figures for mitragynine depend entirely on what is being weighed. Dried leaf commonly runs 12-21 mg/g mitragynine and some resins 35-63 mg/g, so identical gram weights of different material can differ several-fold in active content, and isolated mitragynine is not interchangeable with leaf by weight at all.

    ROA Light Common Strong Heavy
    Oral 1-2g 2-5g 5-8g 8g+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Peak Offset After Effects Total
    Oral 15-45 min 1-2 hrs 2-4 hrs 24 hrs 4-6 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.9
    Strong 6/10

    Moderate euphoria and focus with low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    0
    Opioid 5.1
    Moderate+ 5/10

    Moderate euphoria, sedation, and itching/nausea with mild pain relief

    Euphoria / Warmth ×3
    6
    physical euphoria cognitive euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    6
    sedation muscle relaxation dream potentiation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Mitragynine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Mitragynine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Mitragynine
    Unit
    g
    Description 
    Mitragynine
Source: SubstanceSearch (substancesearch.com)

Oral dose (g): threshold 0.5-1 · light 1-2 · common 2-5 · strong 5-8 · heavy 8+

Oral duration: onset 15-45m · peak 1-2h · offset 2-4h · total 4-6h · after-effects 24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 3.5 g (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 7d Half tolerance 7d Baseline ~35d

    Daily use rapidly builds tolerance and produces a short, opioid‑like withdrawal; most users report substantial recovery within 3–7 days after cessation. Cross‑tolerance with other MOR agonists is partial. Data quality is primarily observational/user‑reported; controlled human data are limited.

    Cross-Tolerances

    Other opioids
    50%

    Effects dose.wiki

    Positive
    • Stimulation
    • Physical euphoria
    • Pain relief
    • Cough suppression
    • Muscle relaxation
    Negative
    • Nausea
    • Increased perspiration
    Neutral
    • Sedation
    • Pupil constriction
    • Itchiness
    • Difficulty urinating
    • Sleepiness
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Empathy, affection, and sociability enhancement
    • Focus enhancement
    • Motivation enhancement
    • Dream potentiation
    Negative
    • Thought deceleration
    • Constipation
    • Dizziness
    • Irritability
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Increased music appreciation
    • Auditory enhancement
    Negative
    • Appetite suppression
    • Decreased libido
    • Orgasm suppression
    Neutral
    • Visual disconnection
    • Internal hallucination
    • Drifting
    • Auditory hallucinations
    • Internal hallucinations

    Combinations

    Cross-Check Mitragynine with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Bluelight 1 thread 1 neutral visit
    5g 7 Mitragynine Alkaloid Blend First Time Ignorance Pays Few Dividends neutral

    When reading unpleasant/negative trip reports, it never fails to amaze me how: A) The Bluelight forums and/or search engine + erowid, could almost certainly have provided enough information to prevent/limit the degree to which a user mistakenly set off on a journey into probable unpleasantness.

    scraped 2026-03-14
    Mitragynine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki