Home
    Disclaimer
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.
    ⚠ This substance has both stimulant and depressant properties, which can mask the effects of each other and increase the risk of overdose or cardiovascular complications.

    Mitragynine

    Aliases: 9-methoxycorynantheidine

    Depressant Stimulant Opioid

    Summary TheDrug.Wiki

    Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contribute to reduced respiratory depression risk compared to morphine. However, pure extracts carry significantly greater overdose risk than plant material due to the natural nausea ceiling in leaf powder.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral (Plant Material) 15-45 min 30-60 min 1-2 hrs 2-4 hrs 24-24 hrs
    Oral (Pure Mitragynine) 15-45 min 30-60 min 1-2 hrs 2-4 hrs 24-24 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.9
    Strong 6/10

    Moderate euphoria and focus with low stimulation

    Stimulation / Energy ×3
    3
    stimulation
    Euphoria / Mood Lift ×2
    7
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    0
    Opioid 5.1
    Moderate+ 5/10

    Moderate euphoria, sedation, and itching/nausea with mild pain relief

    Euphoria / Warmth ×3
    6
    physical euphoria cognitive euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    6
    sedation muscle relaxation dream potentiation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Mitragynine
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 7d Half tolerance 3d Baseline ~14d

    Daily use rapidly builds tolerance and produces a short, opioid‑like withdrawal; most users report substantial recovery within 3–7 days after cessation. Cross‑tolerance with other MOR agonists is partial. Data quality is primarily observational/user‑reported; controlled human data are limited.

    Cross-Tolerances

    Other opioids
    50%

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    • Pain relief
    • Cough suppression
    • Muscle relaxation
    Negative
    • Nausea
    • Increased perspiration
    Neutral
    • Sedation
    • Pupil constriction
    • Itchiness
    • Difficulty urinating
    • Sleepiness
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Empathy, affection, and sociability enhancement
    • Focus enhancement
    • Motivation enhancement
    • Dream potentiation
    Negative
    • Thought deceleration
    • Constipation
    • Dizziness
    • Irritability
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Increased music appreciation
    • Auditory enhancement
    Negative
    • Appetite suppression
    • Decreased libido
    • Orgasm suppression
    Neutral
    • Visual disconnection
    • Internal hallucination
    • Drifting
    • Auditory hallucinations
    • Internal hallucinations

    Combinations TripSit

    Mitragynine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki