When reading unpleasant/negative trip reports, it never fails to amaze me how: A) The Bluelight forums and/or search engine + erowid, could almost certainly have provided enough information to prevent/limit the degree to which a user mistakenly set off on a journey into probable unpleasantness.
Mitragynine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Aliases: 9-methoxycorynantheidine
Summary
Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contribute to reduced respiratory depression risk compared to morphine. However, pure extracts carry significantly greater overdose risk than plant material due to the natural nausea ceiling in leaf powder.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 1-2g | 2-5g | 5-8g | 8g+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 15-45 min | 1-2 hrs | 2-4 hrs | 4-6 hrs |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
5.9
Strong
6/10
Moderate euphoria and focus with low stimulation
Stimulation / Energy
×3
3
stimulation
Euphoria / Mood Lift
×2
7
physical euphoria
cognitive euphoria
motivation enhancement
Focus / Productivity
×2
7
focus enhancement
motivation enhancement
thought acceleration
Anxiety / Jitters
×1
0
Opioid
5.1
Moderate+
5/10
Moderate euphoria, sedation, and itching/nausea with mild pain relief
Euphoria / Warmth
×3
6
physical euphoria
cognitive euphoria
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
6
sedation
muscle relaxation
dream potentiation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
7d
Half tolerance
7d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Daily use rapidly builds tolerance and produces a short, opioid‑like withdrawal; most users report substantial recovery within 3–7 days after cessation. Cross‑tolerance with other MOR agonists is partial. Data quality is primarily observational/user‑reported; controlled human data are limited.
Cross-Tolerances
Other opioids
50%
Effects
Positive
- Stimulation
- Physical euphoria
- Pain relief
- Cough suppression
- Muscle relaxation
Negative
- Nausea
- Increased perspiration
- Sedation
- Pupil constriction
- Itchiness
- Difficulty urinating
- Sleepiness
Positive
- Cognitive euphoria
- Anxiety suppression
- Empathy, affection, and sociability enhancement
- Focus enhancement
- Motivation enhancement
- Dream potentiation
Negative
- Thought deceleration
- Constipation
- Dizziness
- Irritability
- Time distortion
- Thought acceleration
Positive
- Increased music appreciation
- Auditory enhancement
Negative
- Appetite suppression
- Decreased libido
- Orgasm suppression
- Visual disconnection
- Internal hallucination
- Drifting
- Auditory hallucinations
- Internal hallucinations
Combinations
Cross-Check Mitragynine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Bluelight 1 thread 1 neutral visit
Mitragynine's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Mitragynine? Let us know. Reports are reviewed by moderators — this is not posted publicly.