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    Disclaimer
    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.
    ⚠ This substance has both stimulant and depressant properties, which can mask the effects of each other and increase the risk of overdose or cardiovascular complications.

    Mitragynine

    Aliases: 9-methoxycorynantheidine

    Categories

    Depressant Stimulant Opioid
    Mitragynine structure

    Summary TheDrug.Wiki

    Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contribute to reduced respiratory depression risk compared to morphine. However, pure extracts carry significantly greater overdose risk than plant material due to the natural nausea ceiling in leaf powder. Mitragynine inhibits CYP3A4, CYP2D6, and CYP1A2 enzymes, presenting substantial drug interaction potential. The alkaloid is primarily hepatically metabolized to various metabolites including 7-hydroxymitragynine, which is more potent at μ-opioid receptors.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral (Plant Material) 15-45 min 30-60 min 1-2 hrs 2-4 hrs 24 hrs
    Oral (Pure Mitragynine) 15-45 min 30-60 min 1-2 hrs 2-4 hrs 24 hrs

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Physical euphoria
    • Pain relief
    • Cough suppression
    • Muscle relaxation
    Negative
    • Nausea
    • Increased perspiration
    Neutral
    • Sedation
    • Pupil constriction
    • Itchiness
    • Difficulty urinating
    • Sleepiness
    Positive
    • Cognitive euphoria
    • Anxiety suppression
    • Empathy, affection, and sociability enhancement
    • Focus enhancement
    • Motivation enhancement
    • Dream potentiation
    Negative
    • Thought deceleration
    • Constipation
    • Dizziness
    • Irritability
    Neutral
    • Time distortion
    • Thought acceleration
    Positive
    • Increased music appreciation
    • Auditory enhancement
    Negative
    • Appetite suppression
    • Decreased libido
    • Orgasm suppression
    Neutral
    • Visual disconnection
    • Internal hallucination
    • Drifting
    • Auditory hallucinations
    • Internal hallucinations

    Combinations TripSit

    Helpful Links

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