When reading unpleasant/negative trip reports, it never fails to amaze me how: A) The Bluelight forums and/or search engine + erowid, could almost certainly have provided enough information to prevent/limit the degree to which a user mistakenly set off on a journey into probable unpleasantness.
Mitragynine
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- 29 combo interactions documented
- dose data not in PW/TripSit (unverifiable)
Aliases: 9-methoxycorynantheidine
Summary
Mitragynine is the primary active alkaloid in kratom (Mitragyna speciosa), accounting for 12-66% of total alkaloid content depending on strain origin. Unlike traditional opioids, mitragynine displays functional selectivity and does not activate the β-arrestin-2 pathway, which may contribute to reduced respiratory depression risk compared to morphine. However, pure extracts carry significantly greater overdose risk than plant material due to the natural nausea ceiling in leaf powder.
Dose Information
Dose basis. Dose figures for mitragynine depend entirely on what is being weighed. Dried leaf commonly runs 12-21 mg/g mitragynine and some resins 35-63 mg/g, so identical gram weights of different material can differ several-fold in active content, and isolated mitragynine is not interchangeable with leaf by weight at all. The plant-material threshold is for dried kratom leaf (the Kratom page has the full leaf dose range); pure mitragynine is dosed in milligrams, and a gram of it holds as much mitragynine as roughly 50-80 g of dried leaf.
| ROA | Threshold |
|---|---|
| Oral (Plant Material) | 0.5g |
| Oral (Pure Mitragynine) | 5mg |
Only a threshold dose is documented for this substance — the smallest amount with a noticeable effect. There is no published light/common/strong ladder to show above it.
Sources
Oral (Plant Material)
Dose ladder — DrugsPROOral (Pure Mitragynine)
Dose ladder — DrugsPROOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral (Plant Material) | 15-45 min | 30-60 min | 1-2 hrs | 2-4 hrs | 3.75-7.75 hrs |
| Oral (Pure Mitragynine) | 15-45 min | 30-60 min | 1-2 hrs | 2-4 hrs | 3.75-7.75 hrs |
Effect Profile
Scores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
5.9
Strong
6/10
Moderate euphoria and focus with low stimulation
Stimulation / Energy
×3
3
stimulation
Euphoria / Mood Lift
×2
7
physical euphoria
cognitive euphoria
motivation enhancement
Focus / Productivity
×2
7
focus enhancement
motivation enhancement
thought acceleration
Anxiety / Jitters
×1
0
Opioid
5.1
Moderate+
5/10
Moderate euphoria and sedation with moderate itching/nausea, mild pain relief
Euphoria / Warmth
×3
6
physical euphoria
cognitive euphoria
Analgesia
×2
4
pain relief
Sedation / Relaxation
×1
6
sedation
muscle relaxation
dream potentiation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Cross-Tolerances
Other opioids
Effects
Effect glossary — · full glossary
Positive
Negative
Positive
Negative
Positive
Negative
Combinations
Cross-Check Mitragynine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Bluelight 1 thread 1 neutral visit
Mitragynine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Mitragynine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Name
Mitragynine
Unit
g
Description
Mitragynine Source: SubstanceSearch (substancesearch.com) Oral (Plant Material) dose (g): threshold 0.5 Oral (Pure Mitragynine) dose (mg): threshold 5 Oral (Plant Material) duration: onset 15-45m · come-up 0.5-1h · peak 1-2h · offset 2-4h · total 3.75-7.75h · after-effects 24h Oral (Pure Mitragynine) duration: onset 15-45m · come-up 0.5-1h · peak 1-2h · offset 2-4h · total 3.75-7.75h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
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