Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    N-Methyl-Cyclazodone Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • classified Research-chemical

    Aliases: Nmc, Ld 4202

    Stimulant Nootropic Research-chemical

    Summary dose.wiki

    N-Methyl-Cyclazodone (NMC) is a stimulant of the amphetamine class and a derivative of cyclazodone. It is reported to be approximately 4-6 times more potent than its parent compound, cyclazodone. Human pharmacological data are extremely limited, and because structurally related pemoline analogs have documented hepatotoxicity, caution is warranted with chronic use. A 2022 case report documented severe toxicity requiring hospitalization after approximately 5 g of cumulative intake over 5 days.

    Dose Information dose.wiki PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-20mg 20-30mg 30+ (liver damage may result from heavy or sustained usage) mg
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 20-35 min 15-25 min 5-7 hrs 3-4 hrs - 9-12 hrs
    Sublingual 10-30 min 20-45 min 2-5 hrs 2-3 hrs 3-6 hrs 4.5-9.25 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.6
    Strong 6/10

    Strong anxiety/jitters with moderate stimulation and euphoria, mild focus

    Stimulation / Energy ×3
    7
    stimulation stamina enhancement wakefulness
    Euphoria / Mood Lift ×2
    7
    physical euphoria cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction sweating
    Based on reports from:
    PsychonautWiki N-Methyl-Cyclazodone
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track N-Methyl-Cyclazodone there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "N-Methyl-Cyclazodone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    N-Methyl-Cyclazodone
    Unit
    mg
    Description 
    N-Methyl-Cyclazodone
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 5 · light 5-10 · common 10-20 · strong 20-30 · heavy 30+ (liver damage may result from heavy or sustained usage)
Sublingual dose (mg): threshold 2

Oral duration: onset 20-35m · come-up 15-25m · peak 5-7h · offset 3-4h · total 9-12h
Sublingual duration: onset 10-30m · come-up 20-45m · peak 2-5h · offset 2-3h · total 4.5-9.25h · after-effects 3-6h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 5d Half tolerance 4d Baseline ~18d

    Estimates above reflect community patterns for stimulant tolerance accrual and decay and the similarity between NMC and cyclazodone; no human pharmacology studies define exact rates. Frequent use (>2x/week) appears to blunt mood/drive and increase side effects. Data quality: anecdotal.

    Cross-Tolerances

    Cyclazodone
    70%
    Pemoline derivatives
    50%
    Amphetamine-class stimulants
    30%

    Effects dose.wiki

    Positive
    • Stimulation
    • Physical euphoria
    • Stamina enhancement
    Negative
    • Increased heart rate
    • Pupil dilation
    • Vasoconstriction
    • Increased blood pressure
    • Nausea
    • Teeth grinding
    • Sweating
    • Insomnia
    Neutral
    • Brightness alteration
    Positive
    • Focus enhancement
    • Wakefulness
    • Motivation enhancement
    • Cognitive euphoria
    • Empathy enhancement
    • Sociability enhancement
    • Verbal fluency enhancement
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Bodily control enhancement
    • Increased libido
    • Color enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    Neutral
    • Dulled perception

    Combinations

    Cross-Check N-Methyl-Cyclazodone with another substance

    N-Methyl-Cyclazodone's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki