Naloxone - Substance Search

Summary PsychonautWiki

Naloxone (commonly sold under the brand names Narcan and Evzio) is a synthetic mu-opioid antagonist of the morphinan chemical class that is widely used to reverse the effects of an acute opioid overdose. Naloxone is sold under the brand name Narcan as a nasal spray and Evzio as an auto-injector with voice instructions.

Dose Information PsychonautWiki

ROA	Light	Common	Strong	Heavy
Insufflated	-	1-4mg	-	-
Intramuscular	-	0.4-2mg	-	-
Intravenous	-	0.4-2mg	-	-
Oral	4-8mg	8-16mg	16-28mg	28mg+

Light Common Strong Heavy

Onset, Duration & After-effects PsychonautWiki

ROA	Onset	Comeup	Peak	Offset	After Effects	Total
Insufflated	0-10 min	-	-	-	-	30-60 min
Intramuscular	0-2 min	-	-	-	-	30-60 min
Intravenous	0-2 min	-	-	-	-	30-60 min
Oral	6-12 min	18-42 min	1-2 hrs	30-60 min	1-12 hrs	1.9-3.9 hrs

Effect Profile

46 reports

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Validated against 46 Erowid trip reports
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Opioid 6.6

Strong+ 7/10

Strong euphoria, itching/nausea, and sedation with mild pain relief

Euphoria / Warmth ×3

10

physical euphoria euphoria cognitive euphoria mood lift

Analgesia ×2

4

analgesia

Sedation / Relaxation ×1

8

sedation dream potentiation

⚠ Itching / Nausea ×1

10

nausea constipation dry mouth

Based on reports from:

Erowid Experience Reports PsychonautWiki Naloxone

Import into PsychonautWiki Journal

The PsychonautWiki Journal app includes Naloxone, but its built-in data can be thinner than ours. Importing this file adds a separate "Naloxone (Substance Search)" custom substance with our dose ranges, durations and tolerance, so you can log against whichever you prefer.

⬇ Download import file Import this file as custom substances and you get "Naloxone (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer.

Ranges are harm-reduction guidance, not a prescription.

Tolerance

Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance

Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

Tolerance Decay

Full tolerance 1d Half tolerance 21d Baseline ~35d

Effects Erowid

Aggregated from 46 Erowid experience reports

Positive Effects 10

Sedation 30.4% 70%

Anxiety Suppression 30.4% 70%

Euphoria 28.3% 70%

Empathy 26.1% 70%

Stimulation 26.1% 70%

Tactile Enhancement 10.9% 70%

Focus Enhancement 6.5% 70%

Color Enhancement 6.5% 70%

Music Enhancement 6.5% 70%

Body High 6.5% 70%

Adverse Effects 5

Nausea 19.6% 70%

Confusion 17.4% 70%

Headache 17.4% 70%

Increased Heart Rate 8.7% 70%

Sweating 6.5% 70%

Combinations

Cross-Check Naloxone with another substance

Community Trip Reports

Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

Erowid 2 reports 1 positive 1 neutral visit

Fantasdick positive exp #101369

I got an 8mg Suboxone strip from a friend. I read a few reports of people that had done Suboxone, the very few that I could find that were for recreational use and not to treat withdrawal, and they were all about how sick everyone got.

Driftin In neutral exp #71559

[Erowid Note: Intravenous (IV) injection of crushed pills/tablets can be very dangerous due to unknown substances, binders, and fillers present. Any substance injected directly into the blood stream should be very pure.

Naloxone's nerd page Pharmacology, chemical data, effect profiles, and more

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Helpful Links

💊 Pill Identifier 📘 Experience Reports 📖 PsychonautWiki

Report an issue or suggest an edit

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Naloxone Encyclopedic Encyclopedic Typical encyclopedia coverage. Cross-reference for important decisions. 1 source 1 ROA with full dose ladder duration data present 19 combo interactions documented toxicity data (PsychonautWiki)