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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Naloxone

    Depressant Opioid

    Summary PsychonautWiki

    Naloxone (commonly sold under the brand names Narcan and Evzio) is a synthetic mu-opioid antagonist of the morphinan chemical class that is widely used to reverse the effects of an acute opioid overdose. Naloxone is sold under the brand name Narcan as a nasal spray and Evzio as an auto-injector with voice instructions.

    Dose Information PsychonautWiki

    ROA Light Common Strong Heavy
    Insufflated - 1-4mg - -
    Intramuscular - 0.4-2mg - -
    Intravenous - 0.4-2mg - -
    Oral 4-8mg 8-16mg 16-28mg 28mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 6-12 min 18-42 min 1-2 hrs 30-60 min 1-12 hrs

    Effect Profile

    46 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 46 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.6
    Strong+ 7/10

    Strong euphoria, itching/nausea, and sedation with mild pain relief

    Euphoria / Warmth ×3
    10
    physical euphoria euphoria cognitive euphoria mood lift
    Analgesia ×2
    4
    analgesia
    Sedation / Relaxation ×1
    8
    sedation dream potentiation
    ⚠ Itching / Nausea ×1
    10
    nausea constipation dry mouth
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Naloxone
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects Erowid

    Aggregated from 46 Erowid experience reports

    Positive Effects 10

    Sedation 30.4% 70%
    Anxiety Suppression 30.4% 70%
    Euphoria 28.3% 70%
    Empathy 26.1% 70%
    Stimulation 26.1% 70%
    Tactile Enhancement 10.9% 70%
    Focus Enhancement 6.5% 70%
    Color Enhancement 6.5% 70%
    Music Enhancement 6.5% 70%
    Body High 6.5% 70%

    Adverse Effects 5

    Nausea 19.6% 70%
    Confusion 17.4% 70%
    Headache 17.4% 70%
    Increased Heart Rate 8.7% 70%
    Sweating 6.5% 70%

    Combinations TripSit

    Naloxone's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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