Summary
Naloxone (commonly sold under the brand names Narcan and Evzio) is a synthetic mu-opioid antagonist of the morphinan chemical class that is widely used to reverse the effects of an acute opioid overdose. Naloxone is sold under the brand name Narcan as a nasal spray and Evzio as an auto-injector with voice instructions.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | - | 1-4mg | - | - |
| Intramuscular | - | 0.4-2mg | - | - |
| Intravenous | - | 0.4-2mg | - | - |
| Oral | 4-8mg | 8-16mg | 16-28mg | 28mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Insufflated | 0-12 min | - | - | - | - |
| Intramuscular | 0 min | - | - | - | - |
| Intravenous | 0 min | - | - | - | - |
| Oral | 6-12 min | 18-42 min | 1-2 hrs | 30-60 min | 1-12 hrs |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Analgesia
- Physical euphoria
- Cough suppression
Negative
- Motor impairment
- Nausea
- Dry Mouth
- Sedation
- Itchiness
- Relaxant
- Difficulty urinating
Positive
- Reduced anxiety
- Euphoria
- Cognitive euphoria
- Mood lift
- Cognitive Euphoria
- Anxiety Suppression
- Anxiety suppression
- Dream potentiation
Negative
- Constipation
- Compulsive redosing
Positive
- Visual geometry
- Increased music appreciation
Negative
- Appetite suppression
- Decreased Libido
- Appetite Suppression
- Spatial disorientation
- Dulled perception
- Internal hallucinations
- Internal hallucination
- Visual and auditory hallucinations