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    Nifoxipam molecular structure

    Nifoxipam Stats & Data

    Depressant Research-chemical Benzodiazepine
    Dp 370 3-oh-norflunitrazepam
    NPS DataHub
    MW315.26
    FormulaC15H10FN3O4
    CAS74723-10-7
    IUPAC5-(2-fluorophenyl)-3-hydroxy-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
    SMILESO=N(=O)c1ccc2NC(=O)C(O)N=C(c3ccccc3F)c2c1
    InChIKeyUHFIFTRHLBAWGY-UHFFFAOYSA-N
    Benzodiazepines; 2020/3. Benzodiazepine; 2021/3. Benzodiazepine; 2022/3. Benzodiazepine
    Chemical Class Benzodiazepine
    Psychoactive Class Depressant

    Interaction Warnings

    ⚠ dissociatives

    This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

    ⚠ stimulants

    It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects.

    Receptor Profile

    Receptor Actions

    Modulators
    GABAs-A receptor positive allosteric modulator (benzodiazepine site)

    History & Culture

    Nifoxipam is a nitrobenzodiazepine that was originally identified as a minor metabolite of flunitrazepam (marketed as Rohypnol). While it exists primarily as an analytical reference material in pharmacological research, the compound has since emerged on the online designer drug market. It is currently sold by research chemical vendors as a recreational psychoactive substance. Despite having potential applications for the short-term treatment of anxiety, insomnia, acute seizures, and sedation of hospitalized patients, nifoxipam has never been approved for medicinal use and remains unscheduled in most jurisdictions. The compound represents part of the broader trend of benzodiazepine metabolites and analogues appearing in the grey-market research chemical trade.

    Subjective Effect Notes

    physical: The physical effects of nifoxipam can be broken down into several components which progressively intensify proportional to dosage.

    cognitive: The general head space of nifoxipam is described by many as one of intense sedation and decreased inhibition. It contains a large number of typical depressant cognitive effects.

    Effect Profile

    Curated + 1 Reports
    Benzodiazepine 7.0

    Strong anxiolysis and cognitive impairment with moderate sedation and euphoria

    Anxiolysis×3
    10
    Sedation / Relaxation×2
    6
    Motor / Cognitive Impairment×1
    9
    Euphoria / Mood Lift×1
    6
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Nifoxipam

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Cross-Tolerances

    Alprazolam
    30% ●○○
    Diazepam
    30% ●○○
    Clonazepam
    30% ●○○
    Lorazepam
    30% ●○○
    Etizolam
    30% ●○○
    Bromazolam
    30% ●○○
    Clonazolam
    30% ●○○
    Flualprazolam
    30% ●○○

    Experience Report Analysis

    Erowid
    1 Reports
    2015–2015 Date Range
    1 With Age Data

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Read full reports on Erowid →

    Legal Status

    Country Status Notes
    Canada Schedule IV CDSA Controlled as a benzodiazepine under Schedule IV of the Controlled Drugs and Substances Act. All benzodiazepines fall under this scheduling regardless of specific listing.
    Germany NpSG (Controlled) Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since July 18, 2019. Production, import with intent to distribute, administration to others, and trading are criminal offenses. Possession is prohibited but carries no criminal penalty.
    Russia Schedule III Classified as a Schedule III controlled substance since 2017. Subject to restrictions on possession, distribution, and manufacturing.
    Switzerland Verzeichnis E (Controlled) Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics scheduling. Possession and distribution require authorization.
    Turkey Illegal Classified as a controlled drug under national legislation. Possession, production, supply, and importation are prohibited.
    United Kingdom Psychoactive Substances Act 2016 Controlled under the Psychoactive Substances Act, effective May 26, 2016. Production, supply, and importation are criminal offenses. Personal possession is not criminalized under this act, though intent to supply remains prosecutable.

    References

    Data Sources

    Cited References

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