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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Nifoxipam Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 3 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 27 combo interactions documented
    • toxicity data (PsychonautWiki)
    • classified Tentative
    • classified Research-chemical

    Aliases: Dp 370, 3-oh-norflunitrazepam

    Depressant Research-chemical Benzodiazepine

    Summary dose.wiki TripSit PsychonautWiki

    Nifoxipam is an active metabolite of flunitrazepam with a half-life estimated at 12-24 hours and subjective effects lasting up to 75 hours in some users. It accumulates strongly with daily dosing; users report coordination loss from 1-2mg and blackouts beyond 2-4mg. Volumetric measurement is essential—dissolve powder in ethanol or propylene glycol for accurate titration.

    Dose Information source varies by route

    ROA Light Common Strong Heavy
    Oral 0.25-0.5mg 0.5-1mg 1-2mg 2mg+
    Sublingual 0.25-0.5mg 0.5-1mg 1-2mg 2mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, PsychonautWiki

    Sublingual

    Dose ladder — Light: same as the Oral row (dose.wiki, PsychonautWiki, TripSit) · Common: same as the Oral row (dose.wiki, PsychonautWiki, TripSit) · Strong, Heavy: same as the Oral row (dose.wiki, PsychonautWiki); no source states a Sublingual ladder

    Onset, Duration & After-effects dose.wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 0.75-2 hrs 2-4 hrs 6-12 hrs 24-48 hrs 12-17 hrs
    Sublingual 10-45 min 2-4 hrs 6-12 hrs 24-48 hrs 10-18 hrs
    Rectal 10-30 min 2-4 hrs 6-12 hrs 24-48 hrs 10-18 hrs

    Effect Profile

    1 reports

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 6.7
    Strong+ 7/10

    Strong anxiolysis with strong cognitive impairment, moderate euphoria, mild sedation

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    9
    motor control loss memory suppression amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    6
    cognitive euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Nifoxipam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

    Cross-Tolerances

    Benzodiazepines
    Alprazolam
    Diazepam
    Clonazepam
    Lorazepam
    Etizolam
    Bromazolam
    Clonazolam
    Flualprazolam

    Effects dose.wiki TripSit

    Positive
    Negative
    Neutral
    Positive
    Negative
    Positive
    Negative
    Neutral

    Combinations TripSit

    Cross-Check Nifoxipam with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 1 report 1 neutral visit
    Questionable neutral exp #105406

    I will start off with listing my benzo experience : Xanax, Clonazepam, Ativan, Etizolam, Diazepam, Valium. This new RC chemical Nifoxipam is what I tried last evening. 6:00 - Took one 2mg (off white scored) pellet. I felt effects within 15 minutes, only a small relaxing feeling and body sedation.

    Chemdick · 2 mg oral
    Bluelight 2 threads 1 positive 1 neutral visit
    Nifoxipam 1mg First Time Melting Sedative Warmth positive

    (Nifoxipam / 1mg) - First Time - Melting sedative warmth Background Info: Body Weight : 53kg Set: Feeling a little anxious about some stuff in real life, wasn't in the best of moods, but not exactly feeling bad either, kind of "could be better" mood.

    1 mg mentioned in the thread; auto-extracted, unverified
    Nifoxipam neutral

    I've heard mixed reports on this one. For me, it has to be one of the best out there. I have a pretty high tolerance to Diclazepam and they have been making me dizzy for days after without much luck in the sense of sedation or positive effects in general.

    4 mg mentioned in the thread; auto-extracted, unverified
    Nifoxipam's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki 📖 TripSit
    Add missing routes to PsychonautWiki Journal

    The PsychonautWiki Journal app already has Nifoxipam, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.

    ⬇ Download import file Import this file as custom substances and you get "Nifoxipam (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Custom Unit doses
    • Sublingualcommon ~ 0.75 mg
    Dose & duration (reference) 
    Nifoxipam: routes the PsychonautWiki Journal app is missing
Source: SubstanceSearch (substancesearch.com)

Sublingual dose (mg): threshold 0.25 · light 0.25-0.5 · common 0.5-1 · strong 1-2 · heavy 2+

Sublingual duration: onset 10-45m · peak 2-4h · offset 6-12h · total 10-18h · after-effects 24-48h
Rectal duration: onset 10-30m · peak 2-4h · offset 6-12h · total 10-18h · after-effects 24-48h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.