I will start off with listing my benzo experience : Xanax, Clonazepam, Ativan, Etizolam, Diazepam, Valium. This new RC chemical Nifoxipam is what I tried last evening. 6:00 - Took one 2mg (off white scored) pellet. I felt effects within 15 minutes, only a small relaxing feeling and body sedation.
Nifoxipam
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 17 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 17 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Tentative
- classified Research-chemical
Aliases: Dp 370, 3-oh-norflunitrazepam
Summary
Nifoxipam is an active metabolite of flunitrazepam with a half-life estimated at 12-24 hours and subjective effects lasting up to 75 hours in some users. It accumulates strongly with daily dosing; users report coordination loss from 1-2mg and blackouts beyond 2-4mg. Volumetric measurement is essential—dissolve powder in ethanol or propylene glycol for accurate titration.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.25-0.5mg | 0.5-1mg | 1-2mg | 2mg+ |
| Sublingual | 0.25-0.5mg | 0.5-1mg | 1-2mg | 2mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 0.75-2 hrs | 2-4 hrs | 6-12 hrs | 12-17 hrs |
| Sublingual | 10-45 min | 2-4 hrs | 6-12 hrs | 10-18 hrs |
| Rectal | 10-30 min | 2-4 hrs | 6-12 hrs | 10-18 hrs |
Effect Profile
1 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Benzodiazepine
6.7
Strong+
7/10
Strong anxiolysis and cognitive impairment with moderate euphoria, mild sedation
Anxiolysis
×3
10
anxiety suppression
anxiolytic
muscle relaxation
muscle relaxant
emotion suppression
Sedation / Relaxation
×2
5
sedation
muscle relaxation
Motor / Cognitive Impairment
×1
9
motor control loss
memory suppression
amnesia
delusions of sobriety
Euphoria / Mood Lift
×1
6
cognitive euphoria
disinhibition
Based on reports from:
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Nifoxipam, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "Nifoxipam (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Custom Unit doses
- Sublingualcommon ~ 0.75 mg
Dose & duration (reference)
Nifoxipam: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Sublingual dose (mg): threshold 0.25 · light 0.25-0.5 · common 0.5-1 · strong 1-2 · heavy 2+ Rectal dose (mg): threshold 0.25 Sublingual duration: onset 10-45m · peak 2-4h · offset 6-12h · total 10-18h · after-effects 24-48h Rectal duration: onset 10-30m · peak 2-4h · offset 6-12h · total 10-18h · after-effects 24-48h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Tolerance Decay
Full tolerance
3d
Half tolerance
37d
Baseline
~60d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Cross-Tolerances
Benzodiazepines
Alprazolam
30%
Diazepam
30%
Clonazepam
30%
Lorazepam
30%
Etizolam
30%
Bromazolam
30%
Clonazolam
30%
Flualprazolam
30%
Effects
Positive
- Muscle relaxation
- Anxiolytic
- Muscle Relaxant
Negative
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Hypnotic
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Motor control loss
- Memory suppression
- Amnesia
- Thought deceleration
- Emotion suppression
- Compulsive redosing
- Delusions of sobriety
- Dizziness
- Analysis suppression
- Delusions
- Information processing suppression
Positive
- Tracers
- Increased Music Appreciation
Negative
- Disinhibition
- Acuity Suppression
- Dulled perception
- Metallic Taste
- Visual Drifting
- External Hallucinations
- Auditory Hallucinations
- Gustatory hallucination
Combinations
Cross-Check Nifoxipam with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 1 report 1 neutral visit
Bluelight 2 threads 2 neutral visit
(Nifoxipam / 1mg) - First Time - Melting sedative warmth Background Info: Body Weight : 53kg Set: Feeling a little anxious about some stuff in real life, wasn't in the best of moods, but not exactly feeling bad either, kind of "could be better" mood.
I've heard mixed reports on this one. For me, it has to be one of the best out there. I have a pretty high tolerance to Diclazepam and they have been making me dizzy for days after without much luck in the sense of sedation or positive effects in general.
Nifoxipam's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Nifoxipam? Let us know. Reports are reviewed by moderators — this is not posted publicly.