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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Nifoxipam

    Aliases: Dp 370, 3-oh-norflunitrazepam

    Depressant Research-chemical Benzodiazepine

    Summary TheDrug.Wiki TripSit PsychonautWiki

    Nifoxipam is an active metabolite of flunitrazepam with a half-life estimated at 12-24 hours and subjective effects lasting up to 75 hours in some users. It accumulates strongly with daily dosing; users report coordination loss from 1-2mg and blackouts beyond 2-4mg. Volumetric measurement is essential—dissolve powder in ethanol or propylene glycol for accurate titration.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral 0.25-0.5mg 0.5-1mg 1-2mg 2mg+
    Sublingual 0.25-0.5mg 0.5-1mg 1-2mg 2mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Oral 0.75-2 hrs 2-4 hrs 6-12 hrs 24-48 hrs 8.8-18 hrs
    Sublingual 10-45 min 2-4 hrs 6-12 hrs 24-48 hrs 8.2-16.8 hrs
    Rectal 10-30 min 2-4 hrs 6-12 hrs 24-48 hrs 8.2-16.5 hrs

    Effect Profile

    1 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.0
    Strong+ 7/10

    Strong anxiolysis and cognitive impairment with moderate sedation and euphoria

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression
    Sedation / Relaxation ×2
    6
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    9
    motor control loss memory suppression amnesia delusions of sobriety
    Euphoria / Mood Lift ×1
    6
    cognitive euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Nifoxipam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d

    Cross-Tolerances

    Benzodiazepines
    Alprazolam
    30%
    Diazepam
    30%
    Clonazepam
    30%
    Lorazepam
    30%
    Etizolam
    30%
    Bromazolam
    30%
    Clonazolam
    30%
    Flualprazolam
    30%

    Effects TheDrug.Wiki TripSit

    Positive
    • Muscle relaxation
    • Anxiolytic
    • Muscle Relaxant
    • Muscle Relaxation
    Negative
    • Respiratory depression
    • Respiratory Depression
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    • Hypnotic
    Positive
    • Anxiety suppression
    • Cognitive euphoria
    Negative
    • Motor control loss
    • Memory suppression
    • Amnesia
    • Thought deceleration
    • Emotion suppression
    • Compulsive redosing
    • Delusions of sobriety
    • Dizziness
    • Analysis suppression
    • Delusions
    • Information processing suppression
    Positive
    • Tracers
    • Increased Music Appreciation
    Negative
    • Disinhibition
    • Acuity Suppression
    Neutral
    • Dulled perception
    • Metallic Taste
    • Visual Drifting
    • External Hallucinations
    • Auditory Hallucinations
    • Gustatory hallucination

    Combinations TripSit

    Nifoxipam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki 📖 TripSit