Nitrazepam - Substance Search

Summary TheDrug.Wiki TripSit

Nitrazepam is a long-acting nitrobenzodiazepine with an intermediate onset, commonly prescribed for insomnia and seizures. As a nitrobenzodiazepine, it is more hepatotoxic than standard benzodiazepines due to CYP3A4 metabolism producing reactive metabolites. Residual hangover effects may persist into the next day, impairing driving ability and increasing fall risk.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	2-5mg	5-15mg	15-20mg	20-30mg+

Light Common Strong Heavy

Benzo Equivalence Calculator

Convert from

mg

Convert to

10.0 mg Nitrazepam

=

— mg Diazepam

⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Peak	Offset	After Effects	Total
Oral	30-60 min	1-4 hrs	6-12 hrs	24-24 hrs	7.5-17 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Benzodiazepine 7.1

Strong+ 7/10

Strong anxiolysis, cognitive impairment, and euphoria with mild sedation

Anxiolysis ×3

10

anxiety suppression anxiolytic muscle relaxation muscle relaxant emotion suppression

Sedation / Relaxation ×2

5

sedation muscle relaxation

⚠ Motor / Cognitive Impairment ×1

10

motor control loss amnesia memory suppression delusions of sobriety double vision

Euphoria / Mood Lift ×1

10

cognitive euphoria physical euphoria disinhibition

Based on reports from:

Erowid Experience Reports PsychonautWiki Nitrazepam

Tolerance

Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance

Reset weeks to months depending on half-life and duration of use; taper recommended

Tolerance Decay

Full tolerance 14d Half tolerance 28d Baseline ~56d

Tolerance to hypnotic and sedative effects develops over days to weeks of regular use and decays over several weeks of abstinence. Cross‑tolerance is substantial across benzodiazepines and partial with non‑benzodiazepine 'Z‑drugs'. Estimates reflect aggregated clinical knowledge and HR guidance; individual variability is high.