Norflurazepam
Aliases: Norfludiazepam, N-desalkylflurazepam, N-desalkyl-2-oxoquazepam
Categories
Summary
Norflurazepam is a long-acting benzodiazepine and an active metabolite of several pharmaceutical benzodiazepines including flurazepam, quazepam, and midazolam. It has been available as a research chemical since 2016. Due to its extremely long half-life (47-150 hours, up to 200 hours in some individuals), it is prone to accumulation with repeated dosing and may remain detectable in the body for days after use. Fatal overdose may occur when combined with other CNS depressants. Legal status varies by jurisdiction; it is controlled in some countries including Canada (Schedule IV).
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-5mg | 5-10mg | 10-20mg | 20mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 30-60 min | 2-4 hrs | 6-12 hrs | 24 hrs | 600-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle relaxation
- Anxiolytic
- Muscle Relaxant
- Physical euphoria
- Seizure suppression
Negative
- Motor impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
Positive
- Anxiety suppression
- Cognitive euphoria
Negative
- Amnesia
- Motor control loss
- Emotion suppression
- Thought deceleration
- Delusions of sobriety
- Compulsive redosing
- Dizziness
- Analysis suppression
Positive
Negative
- Disinhibition
- Decreased Libido
- Acuity Suppression
- Visual acuity suppression
- Appetite suppression
- Acuity suppression
- Dulled perception
- Perception of bodily heaviness
- Appetite fluctuation
- Hallucinations