Norflurazepam
Aliases: Norfludiazepam, N-desalkylflurazepam, N-desalkyl-2-oxoquazepam
Summary
Norflurazepam is a long-acting benzodiazepine and an active metabolite of several pharmaceutical benzodiazepines including flurazepam, quazepam, and midazolam. It has been available as a research chemical since 2016. Due to its extremely long half-life (47-150 hours, up to 200 hours in some individuals), it is prone to accumulation with repeated dosing and may remain detectable in the body for days after use.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-5mg | 5-10mg | 10-20mg | 20mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 30-60 min | 2-4 hrs | 6-12 hrs | 9-19 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiolysis and euphoria with moderate cognitive impairment, mild sedation
Tolerance
Tolerance Decay
Tolerance builds with regular daily use over 2–4 weeks and decays slowly over 4–8 weeks after cessation; cross‑tolerance exists across benzodiazepines. Estimates are based on general benzodiazepine literature rather than norflurazepam-specific trials; interpret as heuristic guidance.
Cross-Tolerances
Effects
- Muscle relaxation
- Anxiolytic
- Muscle Relaxant
- Physical euphoria
- Seizure suppression
- Motor impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Anxiety suppression
- Cognitive euphoria
- Amnesia
- Motor control loss
- Emotion suppression
- Thought deceleration
- Delusions of sobriety
- Compulsive redosing
- Dizziness
- Analysis suppression
- Disinhibition
- Decreased Libido
- Acuity Suppression
- Visual acuity suppression
- Appetite suppression
- Acuity suppression
- Dulled perception
- Perception of bodily heaviness
- Appetite fluctuation
- Hallucinations