O-PCP
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 5 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 3 corroborating sources
- 5 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 2-keto-pcp
Summary
O-PCP has a heavier physical body-load than classic PCP analogues, with users reporting muscle soreness, flu-like malaise, and caustic crystals that irritate mucous membranes. First appeared on European grey-market vendors in early 2025; community reports place potency between ketamine and PCP but with a more sedating body-load and a shorter plateau (approximately 1-2 hours). There is speculation about possible ΞΌ-opioid receptor activity based on structural similarity to 3-HO-PCP, though this remains unconfirmed in humans.
Perspectives
“O-PCP is, at reasonable doses, very boring on its own. It reminds me of MXPr in that regard. It sits in the background, it doesnβt assert itself. It needs friends to be brought out of its shell.”
Dose Information
Dose basis. Ranges are compiled from early community reports; high inter-individual variability expected. Start low, use a calibrated 1 mg scale or volumetric dosing, and wait a full onset before redosing. Anecdotal only. Irritating to mucosa; fine powders can cake and lead to uneven absorption. Dose conservatively and avoid repetitive βbumpsβ due to redose creep. (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3-8mg | 8-18mg | 18-35mg | 35mg+ |
| Insufflated | 2-6mg | 6-12mg | 12-22mg | 22mg+ |
| Vaporized | 3-8mg | 8-15mg | 15-25mg | 25mg+ |
| Rectal | 2-5mg | 5-15mg | 15-30mg | 30mg+ |
| Intramuscular | 1-4mg | 4-10mg | 10-18mg | 18mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 19-40 min | 0.8-2 hrs | 1-2 hrs | 2.12-4.67 hrs |
| Insufflated | 10-19 min | 0.8-2 hrs | 1-2 hrs | 1.97-4.32 hrs |
| Vaporized | 10-20 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Rectal | - | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Intramuscular | 4-15 min | 0.8-2 hrs | 1-2 hrs | 1.87-4.25 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and motor impairment with moderate mania, low insight
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track O-PCP there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
O-PCP Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 3 Β· light 3-8 Β· common 8-18 Β· strong 18-35 Β· heavy 35+ Insufflated dose (mg): threshold 2 Β· light 2-6 Β· common 6-12 Β· strong 12-22 Β· heavy 22+ Vaporized dose (mg): threshold 3 Β· light 3-8 Β· common 8-15 Β· strong 15-25 Β· heavy 25+ Rectal dose (mg): threshold 2 Β· light 2-5 Β· common 5-15 Β· strong 15-30 Β· heavy 30+ Intramuscular dose (mg): threshold 1 Β· light 1-4 Β· common 4-10 Β· strong 10-18 Β· heavy 18+ Oral duration: onset 19-40m Β· peak 0.8-2h Β· offset 1-2h Β· total 2.12-4.67h Β· after-effects 1-8h Insufflated duration: onset 10-19m Β· peak 0.8-2h Β· offset 1-2h Β· total 1.97-4.32h Β· after-effects 1-8h Vaporized duration: onset 10-20m Β· peak 0.8-2h Β· offset 1-2h Β· total 3-5h Β· after-effects 1-8h Rectal duration: peak 0.8-2h Β· offset 1-2h Β· total 3-5h Β· after-effects 1-8h Intramuscular duration: onset 4-15m Β· peak 0.8-2h Β· offset 1-2h Β· total 1.87-4.25h Β· after-effects 1-8h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 13 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Pattern inferred from dissociative class reports (e.g., ketamine/MXE): rapid acute tolerance after a single heavy session; partial decay over 2β4 days; nearβbaseline after about a week. Data are anecdotal; individual variability is large.
Cross-Tolerances
Effects
- Analgesia
- Physical euphoria
- Stimulation
- Pain relief
- Numbness
- Loss of balance
- Nausea
- Increased heart rate
- Physical disconnection
- Sedation
- Euphoria
- Conceptual thinking
- Cognitive euphoria
- Cognitive disconnection
- Depersonalization
- Motor control loss
- Derealization
- Amnesia
- Memory suppression
- Time distortion
- Increased music appreciation
- Tactile enhancement
- Visual acuity suppression
- Derealization
- Disinhibition
- Tactile suppression
- Spatial disorientation
- Double vision
- Visual disconnection
- Auditory distortion
Combinations
Cross-Check O-PCP with another substanceHelpful Links
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