O-PCP
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Encyclopedic
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- 2 corroborating sources
- 5 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 2 corroborating sources
- 5 ROAs with full dose ladders
- duration data present
- 18 combo interactions documented
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: 2-keto-pcp
Summary
O-PCP has a heavier physical body-load than classic PCP analogues, with users reporting muscle soreness, flu-like malaise, and caustic crystals that irritate mucous membranes. First appeared on European grey-market vendors in early 2025; community reports place potency between ketamine and PCP but with a more sedating body-load and a shorter plateau (approximately 1-2 hours). There is speculation about possible ฮผ-opioid receptor activity based on structural similarity to 3-HO-PCP, though this remains unconfirmed in humans.
Perspectives
“O-PCP is, at reasonable doses, very boring on its own. It sits in the background, it doesn't assert itself. It needs friends to be brought out of its shell. Use it like a spice.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 3-8mg | 8-18mg | 18-35mg | 35mg+ |
| Insufflated | 2-6mg | 6-12mg | 12-22mg | 22mg+ |
| Vaporized | 3-8mg | 8-15mg | 15-25mg | 25mg+ |
| Rectal | 2-5mg | 5-15mg | 15-30mg | 30mg+ |
| Intramuscular | 1-4mg | 4-10mg | 10-18mg | 18mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-40 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Insufflated | 10-20 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Vaporized | 10-20 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Rectal | - | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
| Intramuscular | 5-15 min | 0.8-2 hrs | 1-2 hrs | 3-5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong dissociative depth and motor impairment with moderate mania, low insight
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session โ the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Pattern inferred from dissociative class reports (e.g., ketamine/MXE): rapid acute tolerance after a single heavy session; partial decay over 2โ4 days; nearโbaseline after about a week. Data are anecdotal; individual variability is large.
Cross-Tolerances
Effects
- Analgesia
- Physical euphoria
- Stimulation
- Pain relief
- Numbness
- Loss of balance
- Nausea
- Increased heart rate
- Physical disconnection
- Sedation
- Euphoria
- Conceptual thinking
- Cognitive euphoria
- Cognitive disconnection
- Depersonalization
- Motor control loss
- Derealization
- Amnesia
- Memory suppression
- Time distortion
- Increased music appreciation
- Tactile enhancement
- Visual acuity suppression
- Derealization
- Disinhibition
- Tactile suppression
- Spatial disorientation
- Double vision
- Visual disconnection
- Auditory distortion
Combinations
Cross-Check O-PCP with another substanceHelpful Links
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