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    Disclaimer
    โš  PCP and its analogues are potent dissociatives with significant risk of psychosis, violent behavior, and overdose. Effects are highly unpredictable and dose-sensitive.
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    O-PCP

    Aliases: 2-keto-pcp

    Categories

    Dissociative Research-chemical

    Summary TheDrug.Wiki

    O-PCP has a heavier physical body-load than classic PCP analogues, with users reporting muscle soreness, flu-like malaise, and caustic crystals that irritate mucous membranes. First appeared on European grey-market vendors in early 2025; community reports place potency between ketamine and PCP but with a more sedating body-load and a shorter plateau (approximately 1-2 hours). There is speculation about possible ฮผ-opioid receptor activity based on structural similarity to 3-HO-PCP, though this remains unconfirmed in humans. The powder is hygroscopic and electrostatically clingy; volumetric dosing in propylene glycol or ethanol-water solution (10 mg/mL) is strongly recommended to avoid milligram-scale dosing errors. Cross-tolerance with other arylcyclohexylamines develops rapidly; spacing sessions by at least 7 days is advised to restore baseline NMDA receptor sensitivity.

    Perspectives

    “O-PCP is, at reasonable doses, very boring on its own. It sits in the background, it doesn't assert itself. It needs friends to be brought out of its shell. Use it like a spice.”

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Oral 19-40 min 0.8-2.0 hrs 1.0-2.0 hrs 1.0-8.0 hrs
    Insufflated 10-19 min 0.8-2.0 hrs 1.0-2.0 hrs 1.0-8.0 hrs
    Vaporized / Inhaled 4-15 min 0.8-2.0 hrs 1.0-2.0 hrs 1.0-8.0 hrs
    Rectal (Boofed) 15-30 min 0.8-2.0 hrs 1.0-2.0 hrs 1.0-8.0 hrs
    Intramuscular 4-15 min 0.8-2.0 hrs 1.0-2.0 hrs 1.0-8.0 hrs

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2โ€“4 weeks for noticeable reduction
    Cross-tolerance
    Ketamine PCP Methoxetamine

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Physical euphoria
    • Stimulation
    • Pain relief
    Negative
    • Numbness
    • Loss of balance
    • Nausea
    • Increased heart rate
    Neutral
    • Physical disconnection
    • Sedation
    Positive
    • Euphoria
    • Conceptual thinking
    • Cognitive euphoria
    Negative
    • Cognitive disconnection
    • Depersonalization
    • Motor control loss
    • Derealization
    • Amnesia
    • Memory suppression
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Visual acuity suppression
    • Derealization
    • Disinhibition
    • Tactile suppression
    • Spatial disorientation
    • Double vision
    Neutral
    • Visual disconnection
    • Auditory distortion

    Combinations TripSit

    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– Bluelight ๐Ÿ“– PsychonautWiki