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    Disclaimer
    โš  PCP and its analogues are potent dissociatives with significant risk of psychosis, violent behavior, and overdose. Effects are highly unpredictable and dose-sensitive.
    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    O-PCP

    Aliases: 2-keto-pcp

    Dissociative Research-chemical

    Summary TheDrug.Wiki

    O-PCP has a heavier physical body-load than classic PCP analogues, with users reporting muscle soreness, flu-like malaise, and caustic crystals that irritate mucous membranes. First appeared on European grey-market vendors in early 2025; community reports place potency between ketamine and PCP but with a more sedating body-load and a shorter plateau (approximately 1-2 hours). There is speculation about possible ฮผ-opioid receptor activity based on structural similarity to 3-HO-PCP, though this remains unconfirmed in humans.

    Perspectives

    “O-PCP is, at reasonable doses, very boring on its own. It sits in the background, it doesn't assert itself. It needs friends to be brought out of its shell. Use it like a spice.”

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Peak Offset After Effects
    Oral 19-40 min 0.8-2 hrs 1-2 hrs 1-8 hrs
    Insufflated 10-19 min 0.8-2 hrs 1-2 hrs 1-8 hrs
    Vaporized / Inhaled 4-15 min 0.8-2 hrs 1-2 hrs 1-8 hrs
    Rectal (Boofed) 15-30 min 0.8-2 hrs 1-2 hrs 1-8 hrs
    Intramuscular 4-15 min 0.8-2 hrs 1-2 hrs 1-8 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Dissociative 5.7
    Strong 6/10

    Strong dissociative depth and motor impairment with moderate mania, low insight

    Dissociative Depth ×3
    10
    depersonalization derealization physical disconnection cognitive disconnection visual disconnection spatial disorientation +2 more
    ⚠ Mania / Compulsion ×1
    6
    disinhibition stimulation euphoria
    Insight / Novel Thought ×2
    3
    conceptual thinking
    ⚠ Motor / Sensory Impairment ×1
    10
    motor control loss physical disconnection tactile suppression numbness spatial disorientation visual disconnection +1 more
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki O-PCP
    View methodology →

    Tolerance

    Build-up develops with repeated use over days to weeks
    Reset 2โ€“4 weeks for noticeable reduction

    Tolerance Decay

    Full tolerance 1d Half tolerance 2d Baseline ~7d

    Pattern inferred from dissociative class reports (e.g., ketamine/MXE): rapid acute tolerance after a single heavy session; partial decay over 2โ€“4 days; nearโ€‘baseline after about a week. Data are anecdotal; individual variability is large.

    Cross-Tolerances

    ketamine
    60%
    other arylcyclohexylamines
    70%

    Effects TheDrug.Wiki

    Positive
    • Analgesia
    • Physical euphoria
    • Stimulation
    • Pain relief
    Negative
    • Numbness
    • Loss of balance
    • Nausea
    • Increased heart rate
    Neutral
    • Physical disconnection
    • Sedation
    Positive
    • Euphoria
    • Conceptual thinking
    • Cognitive euphoria
    Negative
    • Cognitive disconnection
    • Depersonalization
    • Motor control loss
    • Derealization
    • Amnesia
    • Memory suppression
    Neutral
    • Time distortion
    Positive
    • Increased music appreciation
    • Tactile enhancement
    Negative
    • Visual acuity suppression
    • Derealization
    • Disinhibition
    • Tactile suppression
    • Spatial disorientation
    • Double vision
    Neutral
    • Visual disconnection
    • Auditory distortion

    Combinations TripSit

    O-PCP's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– TheDrug.Wiki ๐Ÿ“– Bluelight ๐Ÿ“– PsychonautWiki