Pagoclone
Summary
Pagoclone is a non-benzodiazepine anxiolytic of the cyclopyrrolone class., While it is closely related to "Z-drugs" (like zolpidem and zopiclone), pagoclone is unique in that it does not produce sedation or as much loss of motor control and amnesia that benzodiazepines and other Z-drugs do. As with many z-drugs, it is reported to cause hallucinations similar to deliriants, albeit with much less pronounced effects. Pagoclone has been considered by David Nutt, in his search for alcohol alternatives, as a useful base from which to derive viable alternatives.
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Tolerance Decay
Full tolerance
3d
Half tolerance
8d
Baseline
~14d
Effects
Positive
- Stimulation
Negative
- Motor impairment
- Increased heart rate
- Pupil dilation
- Insomnia
- Nausea
- Vasoconstriction
- Restlessness
- Sedation
- Decreased appetite
Positive
- Reduced anxiety
- Euphoria
- Cognitive euphoria
- Wakefulness
- Empathy
Negative
- Anxiety
- Confusion
- Compulsive redosing
- Time distortion
- Talkativeness
Positive
- Increased music appreciation
- Color enhancement
- Tactile enhancement
- Brightened colour
Negative
- Light sensitivity
- Appetite suppression
- Dehydration
- Disinhibition
- Dulled perception
- Drifting
Pagoclone's nerd page
Pharmacology, chemical data, effect profiles, and more
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