Pemoline
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- classified Research-chemical
Summary
Pemoline was used primarily for ADHD and narcolepsy but has been withdrawn in many countries due to rare but severe hepatotoxicity. It is not considered to have strong euphoric or recreational effects compared to other stimulants. Monitoring of liver function is essential if used.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 20-40mg | 40-80mg | 80mg+ |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 30-60 min | 2-4 hrs | 4-8 hrs | 4-13 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong stimulation and anxiety/jitters with mild euphoria and focus
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Pemoline there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Pemoline Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 10-20 · common 20-40 · strong 40-80 · heavy 80+ Oral duration: onset 0.5-1h · peak 2-4h · offset 4-8h · total 4-13h · after-effects 1-6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 30 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Empirical tolerance data specific to pemoline are sparse; patterns likely resemble other prescription stimulants with modest psychological tolerance and limited pharmacodynamic tolerance due to unique mechanism and low euphoria. Users report needing higher doses after weeks of daily use, with partial reversal after several weeks off. Treat as anecdotal.
Cross-Tolerances
Effects
- Mild stimulation
- Stimulation
- Increased energy
- Increased heart rate
- Teeth grinding
- Vasoconstriction
- Pupil dilation
- Increased blood pressure
- Insomnia
- Increased perspiration
- Wakefulness
- Low euphoria
- Alertness enhancement
- Focus enhancement
- Motivation enhancement
- Euphoria
- Anxiety
- Compulsive redosing
- Increased focus
- Talkativeness
- Increased libido
- Increased music appreciation
- Visual enhancement
- Tactile enhancement
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Double vision
- Dulled perception
Combinations
Cross-Check Pemoline with another substancePill Identifiers
Helpful Links
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