Pemoline - Substance Search

Summary TheDrug.Wiki TripSit

Pemoline was used primarily for ADHD and narcolepsy but has been withdrawn in many countries due to rare but severe hepatotoxicity. It is not considered to have strong euphoric or recreational effects compared to other stimulants. Monitoring of liver function is essential if used.

Dose Information TheDrug.Wiki TripSit

ROA	Light	Common	Strong	Heavy
Oral	10-20mg	20-40mg	40-80mg	80mg+

Light Common Strong Heavy

Onset, Duration & After-effects TheDrug.Wiki TripSit

ROA	Onset	Peak	Offset	After Effects	Total
Oral	30-60 min	2-4 hrs	4-8 hrs	1-6 hours	6.5-13 hrs

Effect Profile

Scores (1–10) curated from multiple sources:

Effect keyword matching from PsychonautWiki catalog
Weighted by importance: core (×3), major (×2), minor (×1)

Full methodology

Stimulant 6.2

Strong 6/10

Strong stimulation and anxiety/jitters with mild euphoria and focus

Stimulation / Energy ×3

10

stimulation increased energy wakefulness alertness enhancement mild stimulation

Euphoria / Mood Lift ×2

5

euphoria motivation enhancement

Focus / Productivity ×2

5

focus enhancement motivation enhancement

⚠ Anxiety / Jitters ×1

10

anxiety increased heart rate teeth grinding vasoconstriction

Based on reports from:

Erowid Experience Reports PsychonautWiki Pemoline

Tolerance

Build-up develops over days to weeks of regular use

Reset 3–7 days for acute; 1–3 weeks for full reset

Tolerance Decay

Full tolerance 14d Half tolerance 7d Baseline ~28d

Empirical tolerance data specific to pemoline are sparse; patterns likely resemble other prescription stimulants with modest psychological tolerance and limited pharmacodynamic tolerance due to unique mechanism and low euphoria. Users report needing higher doses after weeks of daily use, with partial reversal after several weeks off. Treat as anecdotal.