Summary
Pemoline was used primarily for ADHD and narcolepsy but has been withdrawn in many countries due to rare but severe hepatotoxicity. It is not considered to have strong euphoric or recreational effects compared to other stimulants. Monitoring of liver function is essential if used.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 20-40mg | 40-80mg | 80mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 2-4 hrs | 4-8 hrs | 60-0 min | 240-0 min |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Mild stimulation
- Stimulation
- Increased energy
Negative
- Increased heart rate
- Teeth grinding
- Vasoconstriction
- Pupil dilation
- Increased blood pressure
- Insomnia
- Increased perspiration
Positive
- Wakefulness
- Low euphoria
- Alertness enhancement
- Focus enhancement
- Motivation enhancement
- Euphoria
Negative
- Anxiety
- Compulsive redosing
- Increased focus
- Talkativeness
Positive
- Increased libido
- Increased music appreciation
- Visual enhancement
- Tactile enhancement
Negative
- Appetite suppression
- Light sensitivity
- Dehydration
- Disinhibition
- Double vision
- Dulled perception