Home
    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Pemoline Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • classified Research-chemical

    Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    Pemoline was used primarily for ADHD and narcolepsy but has been withdrawn in many countries due to rare but severe hepatotoxicity. It is not considered to have strong euphoric or recreational effects compared to other stimulants. Monitoring of liver function is essential if used.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 10-20mg 20-40mg 40-80mg 80mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Peak Offset After Effects Total
    Oral 30-60 min 2-4 hrs 4-8 hrs 1-6 hrs 4-6 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 6.2
    Strong 6/10

    Strong stimulation and anxiety/jitters with mild euphoria and focus

    Stimulation / Energy ×3
    10
    stimulation increased energy wakefulness alertness enhancement mild stimulation
    Euphoria / Mood Lift ×2
    5
    euphoria motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety increased heart rate teeth grinding vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Pemoline
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 14d Half tolerance 7d Baseline ~28d

    Empirical tolerance data specific to pemoline are sparse; patterns likely resemble other prescription stimulants with modest psychological tolerance and limited pharmacodynamic tolerance due to unique mechanism and low euphoria. Users report needing higher doses after weeks of daily use, with partial reversal after several weeks off. Treat as anecdotal.

    Cross-Tolerances

    Other stimulants (general)
    30%

    Effects TheDrug.Wiki

    Positive
    • Mild stimulation
    • Stimulation
    • Increased energy
    Negative
    • Increased heart rate
    • Teeth grinding
    • Vasoconstriction
    • Pupil dilation
    • Increased blood pressure
    • Insomnia
    • Increased perspiration
    Positive
    • Wakefulness
    • Low euphoria
    • Alertness enhancement
    • Focus enhancement
    • Motivation enhancement
    • Euphoria
    Negative
    • Anxiety
    • Compulsive redosing
    Neutral
    • Increased focus
    • Talkativeness
    Positive
    • Increased libido
    • Increased music appreciation
    • Visual enhancement
    • Tactile enhancement
    Negative
    • Appetite suppression
    • Light sensitivity
    • Dehydration
    • Disinhibition
    • Double vision
    Neutral
    • Dulled perception

    Combinations TripSit

    Cross-Check Pemoline with another substance

    Pill Identifiers

    5 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Pemoline's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 TripSit 📖 PsychonautWiki