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    Disclaimer
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Prazepam

    Aliases: Reapam, Centrac, Centrax, Pozapam, Prazene, demetrin, lysanxia, prasepine, trepidan

    Depressant Benzodiazepine

    Summary TheDrug.Wiki TripSit

    Prazepam is a long-acting benzodiazepine prodrug that metabolizes into desmethyldiazepam (nordazepam), which has a very long half-life and is responsible for most therapeutic effects. This results in prolonged duration and potential for accumulation with repeated dosing. Tolerance, dependence, and benzodiazepine withdrawal syndrome are significant risks with long-term use.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 5-10mg 10-20mg 20-40mg 40mg+
    Light Common Strong Heavy

    Benzo Equivalence Calculator

    mg
    15.0 mg Prazepam
    =
    — mg Diazepam

    ⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-90 min 1-2 hrs 2-6 hrs 12-24 hrs 24-24 hrs 15.5-33.5 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.1
    Strong+ 7/10

    Strong anxiolysis and cognitive impairment with moderate sedation and euphoria

    Anxiolysis ×3
    10
    anxiety suppression anxiolytic muscle relaxation emotion suppression
    Sedation / Relaxation ×2
    7
    sedation drowsiness muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    10
    motor control loss motor control impairment cognitive impairment amnesia delusions of sobriety double vision
    Euphoria / Mood Lift ×1
    6
    physical euphoria disinhibition
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Prazepam
    View methodology →

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 14d Half tolerance 7d Baseline ~28d

    Sedative/anxiolytic tolerance tends to develop over weeks of daily use and decays slowly due to long‑acting metabolites. Figures are heuristic for planning conservative washouts, not clinical absolutes. Withdrawal risk persists even after perceived effects fade; always taper.

    Cross-Tolerances

    Other benzodiazepines
    80%
    Z‑drugs (zolpidem, zopiclone)
    40%

    Effects TheDrug.Wiki TripSit

    Positive
    • Muscle relaxation
    • Anxiolytic
    • Anticonvulsant
    • Skeletal Muscle Relaxant
    • Physical euphoria
    Negative
    • Motor control impairment
    • Respiratory depression
    Neutral
    • Sedation
    • Sedative
    • Dystaxia
    Positive
    • Anxiety suppression
    Negative
    • Cognitive impairment
    • Drowsiness
    • Amnesia
    • Emotion suppression
    • Delusions of sobriety
    • Dizziness
    • Motor control loss
    • Thought deceleration
    • Compulsive redosing
    Positive
    • Increased libido
    • Appetite enhancement
    Negative
    • Disinhibition
    • Acuity suppression
    • Visual acuity suppression
    • Acuity Suppression
    • Decreased Libido
    • Double vision
    Neutral
    • Dulled perception
    • Perception of bodily heaviness

    Combinations TripSit

    Prazepam's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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