Prazepam
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- PubChem toxicity data
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- PubChem toxicity data
Aliases: Reapam, Centrac, Centrax, Pozapam, Prazene, demetrin, lysanxia, prasepine, trepidan
Summary
Prazepam is a long-acting benzodiazepine prodrug that metabolizes into desmethyldiazepam (nordazepam), which has a very long half-life and is responsible for most therapeutic effects. This results in prolonged duration and potential for accumulation with repeated dosing. Tolerance, dependence, and benzodiazepine withdrawal syndrome are significant risks with long-term use.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-40mg | 40mg+ |
Benzo Equivalence Calculator
| Substance | Equivalent Dose | Potency |
|---|
⚠ These are approximate equivalences for educational and cross-tapering reference. Individual response, tolerance, and half-life differences mean actual equivalence varies. Always consult a healthcare provider for tapering guidance.
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 2-6 hrs | 12-24 hrs | 8-33.5 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiolysis and cognitive impairment with moderate sedation and euphoria
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Prazepam there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
Prazepam Source: SubstanceSearch (substancesearch.com) Oral dose (mg): light 5-10 · common 10-20 · strong 20-40 · heavy 40+ Oral duration: onset 0.5-1.5h · come-up 1-2h · peak 2-6h · offset 12-24h · total 8-33.5h · after-effects 24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 15 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Sedative/anxiolytic tolerance tends to develop over weeks of daily use and decays slowly due to long‑acting metabolites. Figures are heuristic for planning conservative washouts, not clinical absolutes. Withdrawal risk persists even after perceived effects fade; always taper.
Cross-Tolerances
Effects
- Muscle relaxation
- Anxiolytic
- Anticonvulsant
- Skeletal Muscle Relaxant
- Physical euphoria
- Motor control impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
- Anxiety suppression
- Cognitive impairment
- Drowsiness
- Amnesia
- Emotion suppression
- Delusions of sobriety
- Dizziness
- Motor control loss
- Thought deceleration
- Compulsive redosing
- Increased libido
- Appetite enhancement
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Decreased Libido
- Double vision
- Dulled perception
- Perception of bodily heaviness
Combinations
Cross-Check Prazepam with another substanceHelpful Links
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