Prazepam
Aliases: Reapam, Centrac, Centrax, Pozapam, Prazene, demetrin, lysanxia, prasepine, trepidan
Categories
Summary
Prazepam is a long-acting benzodiazepine prodrug that metabolizes into desmethyldiazepam (nordazepam), which has a very long half-life and is responsible for most therapeutic effects. This results in prolonged duration and potential for accumulation with repeated dosing. Tolerance, dependence, and benzodiazepine withdrawal syndrome are significant risks with long-term use. Abrupt discontinuation after extended use can be dangerous and may cause seizures. Not recommended for individuals with respiratory depression, substance abuse history, or during pregnancy.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-40mg | 40mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-90 min | 1-2 hrs | 2-6 hrs | 12-24 hrs | 24 hrs | 480-0 min |
Tolerance
Build-up
develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
Reset
weeks to months depending on half-life and duration of use; taper recommended
Effects
Positive
- Muscle relaxation
- Anxiolytic
- Anticonvulsant
- Skeletal Muscle Relaxant
- Physical euphoria
Negative
- Motor control impairment
- Respiratory depression
- Sedation
- Sedative
- Dystaxia
Positive
- Anxiety suppression
Negative
- Cognitive impairment
- Drowsiness
- Amnesia
- Emotion suppression
- Delusions of sobriety
- Dizziness
- Motor control loss
- Thought deceleration
- Compulsive redosing
Positive
- Increased libido
- Appetite enhancement
Negative
- Disinhibition
- Acuity suppression
- Visual acuity suppression
- Acuity Suppression
- Decreased Libido
- Double vision
- Dulled perception
- Perception of bodily heaviness