Summary
A first generation antihistamine, which also possesses anticholinergic, strong sedative and antipsychotic properties. Once commonly used as a treatment for psychosis, it is now more commonly seen as a component of codeine cough syrups as an anti-nausea agent.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 12.5-25mg | 25-50mg | 50-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 15-30 min | 20-60 min | 4.0-8.0 hrs | 3-5 hrs | 0.0-3.0 hrs | 240-0 min |
Tolerance
Build-up
sedative and antiemetic tolerance develops over 1–2 weeks
Reset
a few days
Effects
Positive
- Physical euphoria
- Stimulation
- Muscle relaxation
- Spontaneous tactile sensations
Negative
- Motor impairment
- Nausea
- Increased heart rate
- Respiratory depression
- Sedation
- Difficulty urinating
Positive
- Reduced anxiety
- Euphoria
- Cognitive euphoria
- Anxiety suppression
Negative
- Anxiety
- Thought deceleration
- Dizziness
- Memory suppression
- Compulsive redosing
- Time distortion
Positive
- Increased libido
- Increased music appreciation
Negative
- Appetite suppression
- Disinhibition
- Dehydration
- Dulled perception
- Internal hallucinations
- Auditory hallucinations
- Drifting
- Auditory distortion