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    Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Propoxyphene Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • PubChem toxicity data

    Summary

    Is an analgesic in the opioid family. It is intended for mild pain and for its antitussive effects. Has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 30-65mg 65-100mg 100-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 20-30 min 1-3 hrs 2-6 hrs 1-3 hrs

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects Erowid

    Aggregated from 13 Erowid experience reports

    Positive Effects 7

    Euphoria 53.8% 70%
    Sedation 46.2% 70%
    Music Enhancement 30.8% 70%
    Tactile Enhancement 30.8% 70%
    Empathy 23.1% 70%
    Stimulation 23.1% 70%
    Anxiety Suppression 23.1% 70%

    Adverse Effects 1

    Nausea 23.1% 70%

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 7 reports 1 positive 6 neutral visit
    Glimpse of Perfection positive exp #64722

    Alright guys, I have a little but of a 'trip report' for you. It's not much, but here goes. At 4ish AM I ingested somewhere around 1.2 grams of Propoxyphene Napsylate. Well, I had a sore throat, very, very sore, and I decided that since I didn't have class that day, I could take all that.

    The Escherian Mind · Propoxyphene (Darvocet) · 6 tablets oral
    Nice But Takes Time Coming On neutral exp #19647

    It's a Friday evening, normally I'd be toking on a spliff, but there is a bad batch of hash doing the rounds, so I decided to lay off it for a week. As a substitute I would probably take about 4-5 30mg codeine (neat, generic) pills, which were actually prescribed for me a couple a months ago for persistent dry cough.

    Ady Qad · 162.5 mg oral / 1625 mg oral
    In My Own Little World neutral exp #48046

    I am curently experimenting with many drugs. I an a daily weed smoker, and have also tried oxycontin, XTC, Klonopin, valium, hydrocodone, cocaine, and several other drugs.

    James · Propoxyphene (Darvocet) · 650 mg insufflated / 100 mg insufflated
    Relaxed and Cozy neutral exp #11887

    I have been experimenting with various drugs for about 13 years. Most of the drugs I have used in the past were illicit, or 'street' drugs. I have had very little experience with pharmaceuticals. A few months ago, I was prescribed Darvon for a back injury.

    beth810 · 130 mg IV
    Unbelievable neutral exp #46416

    Ok to start I am not very experianced with drugs. I am what you would probably consider very young to be taking the drugs I do. I smoke pot occasionally, have taken DXM, all sorts of Pharms (Hydrocodone, Codiene, Oxycodone, Adderall) And was looking through my parents medicine cabinet and saw something called Propoxyph...

    Stratman420 · 1 tablet oral
    Comfortably Numb neutral exp #50935

    4:20 Ingested four darvocets, which have 100 mg of propxyphene and 325 mg of acetaminophen per pill. This is my first time experiencing with Darvocets, so I was going to start with 4 only, but figured what the hell and at 4:30 took my fifth. 5:00 no notable symptoms, really. Chatting on the internet.

    Nicole · 400 mg oral / 100 mg oral
    Ow! neutral exp #115695

    I got my hands on some 65mg (Imprint 5110 V) capsules. When I pried one open I was glad to find the substance in a fine powder inside the capsule, perfect for insufflation. So I separated the powder into 3 small lines.

    pole · 48.75 mg oral

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