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    ⚠ Opioids carry significant risk of respiratory depression, physical dependence, and fatal overdose. Never combine with other depressants.

    Propoxyphene

    Categories

    Opioid Depressant
    Propoxyphene structure

    Summary

    Is an analgesic in the opioid family. It is intended for mild pain and for its antitussive effects. Has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias.

    Dose Information TripSit

    ROA Light Common Strong Heavy
    Oral 30-65mg 65-100mg 100-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 20-30 min 1.0-3.0 hrs 2.0-6.0 hrs 60-0 min

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

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