Propoxyphene Stats & Data
Psychoactive Class
Opioid / Depressant
Pharmacology
DrugBank
Half-life 12.0 hours
Metabolism Hepatic
Mechanism of Action
Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surfac
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Experience Report Analysis
Erowid
13
Reports
1999–2021
Date Range
1
With Age Data
9
Effects Detected
Demographics
Gender Distribution
Age Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 13 experience reports (13 Erowid)
13
Reports
9
Effects Detected
7
Positive
1
Adverse
1
Neutral
Effect Sentiment Distribution
Confidence Distribution
Positive Effects 7
Euphoria
53.8%
70%
Sedation
46.2%
70%
Music Enhancement
30.8%
70%
Tactile Enhancement
30.8%
70%
Empathy
23.1%
70%
Stimulation
23.1%
70%
Anxiety Suppression
23.1%
70%
Adverse Effects 1
Nausea
23.1%
70%
Real-World Dose Distribution
62K DosesFrom 36 individual dose entries
Oral (n=21)
Median: 162.5mg
25th: 100.0mg
75th: 300.0mg
90th: 400.0mg
mg/kg median: 2.051
mg/kg 75th: 3.779
Form / Preparation
Most common forms and preparations reported
Redose Patterns
Redosing behavior across 12 reports
16.7%
Redosed
1.2
Avg Doses