Propranolol
Aliases: Sumial, Ciplar, Inderal, Deralin, Dociton, hemangeol, innopran
Categories
Summary
Propranolol is a non-selective beta blocker primarily used for cardiovascular conditions but widely prescribed off-label for performance and situational anxiety. It reduces physical anxiety symptoms (tremor, palpitations, sweating) but does not address psychological causes. Contraindicated in asthma and COPD due to bronchoconstriction risk. Abrupt discontinuation should be avoided in those with heart disease; taper over 1-2 weeks. Highly lipophilic with high CNS penetration.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-30mg | 40-80mg | 80-140mg | 140mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 1-4 hrs | 4-8 hrs | 60-0 min | 180-0 min |
| Intravenous | 600-0 min | 1-10 min | - | 60-0 min | 180-0 min |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Mild body euphoria/relaxation
- Analgesia
- Anxiolysis
Negative
- Fatigue
- Motor impairment
- Sedation/drowsiness
- Reduced heart rate
- Lowered blood pressure
- Cold extremities
- Sedation
Positive
- Reduced physical symptoms of anxiety
- Decreased performance anxiety
- Reduced anxiety
- Euphoria
- Conceptual thinking
Negative
- Dizziness
- Anxiety
- Memory suppression
- Confusion
- Time distortion
Positive
- Tracers
- Color enhancement
- Tactile enhancement
- Increased music appreciation
- Enhanced tactile sensation
- Pattern recognition enhancement
Negative
- Warmth/tingling
- Dulled perception
- Drifting
- Auditory distortion