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    Psilocin molecular structure

    Psilocin Stats & Data

    Psychedelic Empathogen Research-chemical
    4-ho-dmt 4-oh-dmt Psilocine Psilotsin
    PubChem CID 4980
    PubChem
    MW204.27
    FormulaC12H16N2O
    LogP2.1
    IUPAC3-[2-(dimethylamino)ethyl]-1H-indol-4-ol
    InChIKeySPCIYGNTAMCTRO-UHFFFAOYSA-N
    Chemical Class Tryptamine
    Psychoactive Class Psychedelic

    Pharmacology

    DrugBank

    Metabolism

    Psilocin has known human metabolites that include (2S,3S,4S,5R)-6-[3-[2-(dimethylamino)ethyl-1H-indol-4-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor partial agonist
    5-HT2C receptor agonist
    5-HT1A receptor agonist
    Other
    Activates phospholipase A2 instead of phospholipase C

    Toxicity

    PsychonautWiki PubChem

    Psilocin is non-addictive, is not known to cause brain damage, and has an extremely low toxicity relative to dose. Similar to other psychedelic drugs, there are relatively few physical side effects associated with acute psilocin exposure. Various studies have shown that in reasonable doses in a careful context, it presents little to no negative cognitive, psychiatric or toxic physical consequences.

    Carcinogenicity

    No indication of carcinogenicity to humans (not listed by IARC).

    Effect Profile

    Curated + 12 Reports
    Psychedelic 5.1

    Moderate visuals with mild headspace and body load, low auditory effects

    Visual Intensity×3
    6
    Headspace Depth×3
    5
    Auditory Effects×1
    3
    Body Load / Somatic Effects×1
    5
    Empathogen 5.4

    Strong euphoria and sensory enhancement with low empathy and stimulation

    Empathy / Social Openness×3
    3
    Euphoria / Mood Elevation×2
    9
    Stimulation×1
    3
    Sensory Enhancement×1
    8
    Based on reports from:
    TiHKAL TiHKAL #18: 4-HO-DMT Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki Psilocin

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Oral
    19-45 minutes
    1.5-3 hours
    2-3 hours
    1.5-2 hours
    4-24 hours
    Insufflated
    4-10 minutes
    2.0-4.0 hours
    3.0-12.0 hours

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    LSD
    80% ●○○
    Psilocybin
    85% ●○○
    Mescaline
    65% ●○○
    DMT
    85% ●○○
    5-MeO-DMT
    85% ●○○
    2C-B
    65% ●○○
    2C-E
    65% ●○○
    2C-I
    65% ●○○

    Experience Report Analysis

    Erowid
    12 Reports
    2004–2022 Date Range
    6 With Age Data
    17 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 12 experience reports (12 Erowid)

    12 Reports
    17 Effects Detected
    8 Positive
    3 Adverse
    6 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 8

    Empathy 83.3% 70%
    Music Enhancement 83.3% 70%
    Color Enhancement 75.0% 70%
    Euphoria 66.7% 70%
    Stimulation 58.3% 70%
    Focus Enhancement 41.7% 70%
    Tactile Enhancement 33.3% 70%
    Body High 33.3% 70%

    Adverse Effects 3

    Anxiety 41.7% 70%
    Nausea 41.7% 70%
    Confusion 41.7% 70%

    Real-World Dose Distribution

    62K Doses

    From 20 individual dose entries

    Oral (n=13)

    Median: 15.0mg 25th: 11.0mg 75th: 20.0mg 90th: 25.8mg
    mg/kg median: 0.156 mg/kg 75th: 0.274

    Form / Preparation

    Most common forms and preparations reported

    Read full reports on Erowid →

    Legal Status

    Controlled internationally under the UN Convention on Psychotropic Substances 1971.
    Country Status Notes
    Australia Psilocin is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.
    Russia Psilocin and psilocybin are banned in Russia, due to their status as narcotic drugs, with a criminal penalty for possession of more than 50 mg.
    United States Psilocin is a Schedule I controlled substance in the United States since 1971.

    References

    Data Sources

    Cited References

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