Psilocin
Aliases: 4-ho-dmt, 4-oh-dmt, Psilocine, Psilotsin
Summary
4-Hydroxy-N,N-dimethyltryptamine (also known as 4-HO-DMT, 4-OH-DMT, and psilocin) is a naturally-occurring psychedelic substance of the tryptamine class. Psilocin is the primary psychoactive constituent in certain species of mushrooms, and as a closely related structural analog of the powerful visionary entheogen DMT (also known as N,N-dimethyltryptamine). Psilocin was first isolated and named by Albert Hofmann in 1958.
Perspectives
“Something has started but I decide to join in a full dinner anyway. The effects develop right through the meal, with some hints of animal faces in the pork-chop bones. No movement, nothing flows, but it probably wouldn’t take much effort. Another hour and I am dropping off already. The food? Somehow I doubt it. I would be completely unable to tell this from, say, 80 milligrams of MDMA except that I had a good appetite.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~50% | 10-15mg | 15-25mg | 25-40mg | 40mg+ |
| Insufflated | 2.5-5mg | 5-10mg | 10-15mg | 15mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 19-45 min | 1.5-3 hrs | 2-3 hrs | 1.5-2 hrs |
| Insufflated | 4-10 min | - | 2-4 hrs | 60-90 min |
Effect Profile
12 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate visuals with mild headspace and body load, low auditory effects
Strong euphoria and sensory enhancement with low empathy and stimulation
Tolerance
Tolerance Decay
Effects
Aggregated from 12 Erowid experience reports
Positive Effects 8
Adverse Effects 3
Combinations
PiHKAL / TiHKAL
“Something has started but I decide to join in a full dinner anyway. The effects develop right through the meal, with some hints of animal faces in the pork-chop bones. No movement, nothing flows, but it probably wouldn’t take much effort. Another hour and I am dropping off already. The food? Somehow I doubt it. I would be completely unable to tell this from, say, 80 milligrams of MDMA except that I had a good appetite.”