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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Psilocin Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 6 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 19 combo interactions documented
    • PubChem toxicity data
    • classified Tentative
    • classified Research-chemical

    Aliases: 4-ho-dmt, 4-oh-dmt, Psilocine, Psilotsin

    Summary TheDrug.Wiki TripSit PsychonautWiki

    4-Hydroxy-N,N-dimethyltryptamine (also known as 4-HO-DMT, 4-OH-DMT, and psilocin) is a naturally-occurring psychedelic substance of the tryptamine class. Psilocin is the primary psychoactive constituent in certain species of mushrooms, and as a closely related structural analog of the powerful visionary entheogen DMT (also known as N,N-dimethyltryptamine). Psilocin was first isolated and named by Albert Hofmann in 1958.

    Perspectives

    “Something has started but I decide to join in a full dinner anyway. The effects develop right through the meal, with some hints of animal faces in the pork-chop bones. No movement, nothing flows, but it probably wouldnโ€™t take much effort. Another hour and I am dropping off already. The food? Somehow I doubt it. I would be completely unable to tell this from, say, 80 milligrams of MDMA except that I had a good appetite.”

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Oral BA ~50% 10-15mg 15-25mg 25-40mg 40mg+
    Insufflated 2.5-5mg 5-10mg 10-15mg 15mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 19-45 min 1.5-3 hrs 2-3 hrs 1.5-2 hrs 4-24 hrs
    Insufflated 4-10 min - 2-4 hrs 60-90 min 3-12 hrs

    Effect Profile

    12 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 5.1
    Moderate+ 5/10

    Moderate visuals with mild headspace and body load, low auditory effects

    Visual Intensity ×3
    6
    colour enhancement synaesthesia pattern recognition enhancement visual acuity enhancement
    Headspace Depth ×3
    5
    conceptual thinking thought connectivity time distortion
    Auditory Effects ×1
    3
    synaesthesia
    Body Load / Somatic Effects ×1
    5
    nausea temperature regulation suppression
    Empathogen 5.4
    Moderate+ 5/10

    Strong euphoria and sensory enhancement with low empathy and stimulation

    Empathy / Social Openness ×3
    3
    empathy enhancement
    Euphoria / Mood Elevation ×2
    9
    physical euphoria cognitive euphoria
    Stimulation ×1
    3
    stimulation
    Sensory Enhancement ×1
    8
    tactile enhancement colour enhancement visual acuity enhancement

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7โ€“14 days for baseline

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    Lysergamides
    LSD
    80%
    Tryptamines
    DMT
    85%
    5-MeO-DMT
    85%
    Phenethylamines
    Mescaline
    65%
    2C-B
    65%
    2C-E
    65%
    2C-I
    65%

    Effects Erowid

    Aggregated from 12 Erowid experience reports

    Positive Effects 8

    Empathy 83.3% 70%
    Music Enhancement 83.3% 70%
    Color Enhancement 75.0% 70%
    Euphoria 66.7% 70%
    Stimulation 58.3% 70%
    Focus Enhancement 41.7% 70%
    Tactile Enhancement 33.3% 70%
    Body High 33.3% 70%

    Adverse Effects 3

    Anxiety 41.7% 70%
    Nausea 41.7% 70%
    Confusion 41.7% 70%

    Combinations TripSit

    Cross-Check Psilocin with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.

    Erowid 7 reports 6 neutral 1 cautionary visit
    4Ho The Bell Tolls neutral exp #66467

    Yesterday I gave myself a fair good wallop in the head with 4HO-DMT, at 30mg. I had decided to use my day off for a trip, which I had been promising myself during my week off, but was unable to do, for various reasons. I got well organised, rising early on a gray autumnal morning.

    PippUK · 30 mg oral / oral / smoked
    Psychedelish neutral exp #84332

    [Erowid Note: The dose described in this report is very high, potentially beyond Erowid's 'heavy' range, and could pose serious health risks or result in unwanted, extreme effects.

    PippUK · 4-HO-DMT · 80 mg oral
    My Psilly Week neutral exp #91903

    I was able to procure 100mg of 4-HO-DMT freebase recently. I have had many experiences with mushrooms in the past, and found them to be my favorite drug besides cannabis. The last time I had mushrooms was approximately 7 months ago. I purchased the Psilocin with the intent to push myself to the limits of the drug.

    takeone · 10 mg oral / 10 mg oral / 10 mg oral / 15 mg oral
    God is a Supercomputer neutral exp #95356

    Recently, I was strolling through the park on a crisp winter day, when a sample of synthetic freebase 4-HO-DMT fell from the sky and landed on the hiking path in front of me. Some of the label was in Chinese, for some unknown reason.

    Kapitan · 12 mg oral
    Potent, Savage Nature neutral exp #92564

    By some miracle of god I came into ownership of some synthesized 4-HO-DMT or Psilocin, about ~100mg. Here is my first report with this rare substance: pill A - 15-17mg 4-ho-dmt pill B - 10-12mg 4-ho-dmt 10:30am - pill A ingested 11:00am - yawning more, feeling my body relax more, some stomach flutters, but nothing seri...

    Grnd Galactc Inqstor
    Good Psychedelic Kick on the Rear neutral exp #39219

    Today was set to be the day to try some of my recently extracted and recrystallized psilocin. The crude psilocin was dissolved in heptane:chloroform (3:1 ย– 7 ml total volume). I found it difficult to dissolve, but it slowly went into solution.

    Triptamine · 21 mg buccal / 7.0 mg buccal
    Hugely Enjoyable Dose-Dependent Psychedelic cautionary exp #116652

    I bought 250mg of psilocin powder, and dissolved it in vodka in a small bottle with a dropper to enable accurate dosage. My wife & I were attending a festival, so having no previous experience with the substance, we decided to err on the side of caution and had about 15mg each.

    Murgatron
    Bluelight 6 threads 1 positive 4 neutral 1 cautionary visit
    My First Few Experiences With Pscilocybin Psilocin positive

    I tried shrooms for the first time in the form of tea. I only had a coffee cup full of medium strength, so it was not an intense trip, but beautiful nonetheless. Everything had a slight rainbow-like quality, and I felt very euphoric.

    scraped 2026-03-14
    Psilocin Experienced Psychedelish neutral

    I dug out my vial of 4HO-DMT from the back of my freezer yesterday to provide me with my trip. The vial held about 500mg of the gram I aquired about 3 years ago. I had given about 200mg away, and the rest had been used on vary rare occasions.

    scraped 2026-03-14
    Psilocin 30mg All The Way neutral

    I mainly need to get these thoughts down, and I figured what better place than here? Being quite experienced with taking psilocybin mushrooms, I could never have expected psilocin to affect me the way it did, even though it was my first time with pure psilocin.

    scraped 2026-03-14
    5mg Psilocin Smoked neutral

    So I don't usually write trip reports on bluelight but I believe that some of you may find this interesting, albeit there is not a lot of detail due to such a low dose.

    scraped 2026-03-14

    Bluelight Reference Guide Bluelight

    The Big and Dandy 4-HO-DMT Thread

    This thread is for pure 4-HO-DMT (psilocin), NOT mushrooms. For mushrooms, go to The Big and Dandy Psilocybin Mushrooms Thread. I know this stuff is on the market now. Has anyone started experimenting with it? When I obtain a sample soon, I'll post some trials.

    Read full thread on Bluelight โ†’

    PiHKAL / TiHKAL Shulgin

    TiHKAL #18: 4-HO-DMT

    “Something has started but I decide to join in a full dinner anyway. The effects develop right through the meal, with some hints of animal faces in the pork-chop bones. No movement, nothing flows, but it probably wouldnโ€™t take much effort. Another hour and I am dropping off already. The food? Somehow I doubt it. I would be completely unable to tell this from, say, 80 milligrams of MDMA except that I had a good appetite.”

    โ€” Alexander Shulgin, TiHKAL (with 6.6 mg phosphate ester, orally)

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