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    Psilocybin molecular structure

    Psilocybin Stats & Data

    Psychedelic
    4-po-dmt magic mushrooms psilocybin mushrooms shrooms mushroom psylocybin mushrooms
    PubChem CID 10624
    PubChem
    MW284.25
    FormulaC12H17N2O4P
    LogP-1.6
    IUPAC[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
    InChIKeyQVDSEJDULKLHCG-UHFFFAOYSA-N
    Chemical Class Tryptamine
    Psychoactive Class Psychedelic

    Pharmacology

    DrugBank

    Description

    Cultivated mushroom allergenic extract is used in allergenic testing.

    Toxicity

    PsychonautWiki PubChem

    study ranking various drugs (legal and illegal) based on statements by drug-harm experts. This study rated "mushroom" the least harmful drug overall and for users, and the only drug that didn't get any scores for harm on others.]] Numerous studies have found that psilocybin mushrooms are physiologically well-tolerated and has an extremely low toxicity relative to dose. There is no evidence for long-lasting effects on the brain or other organs and there are no documented deaths attributed to the direct effects of psilocybin mushrooms toxicity. However, it is worth noting that while they may not be capable of causing direct bodily toxicity or death, their use can still present serious hazards. For example, they are capable of strongly impairing the user's judgment and attention span, which may promote erratic or dangerous behaviors.

    LD50

    • LD50: 280 mg/kg (Oral, Rat) (L1143)

    Carcinogenicity

    No indication of carcinogenicity to humans (not listed by IARC).

    Addiction & dependence

    Like other serotonergic psychedelics, psilocybin mushrooms have low abuse potential|low abuse and no physical dependence potential. There are no literature reports of successful attempts to train animals to self-administer a serotonergic psychedelic, which is predictive of abuse liability, indicating that it does not have the necessary pharmacology to either initiate or maintain dependence. Additionally, there is no human clinical evidence that psilocybin mushrooms causes addiction.

    Psychosis & mental-disorder risk

    Psilocybin mushrooms can exacerbate symptoms (e.g. delusions, mania, psychosis) of various mental disorders. Additionally, they can precipitate the early onset of schizophrenia in vulnerable individuals.

    Effect Profile

    Curated + 36 Reports
    Psychedelic 8.6

    Strong visuals, auditory effects, headspace, and body load

    Visual Intensity×3
    1010
    Headspace Depth×3
    910
    Auditory Effects×1
    1010
    Body Load / Somatic Effects×1
    86.3
    Catalog Erowid
    Based on reports from:
    Effect Index An Exploration into the Depths of Psilocybin — LeftoverNinja Effect Index First Trip in Over 6 Months — Josie Effect Index I Found God Inside Myself — Oscarette Bluelight Big & Dandy Thread Erowid Experience Reports PsychonautWiki Psilocybin

    Community Effects

    TripSit
    Negative
    nausea vomiting anxiety seizures

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    LSD
    80% ●○○
    Psilocin
    85% ●○○
    Mescaline
    65% ●○○
    DMT
    85% ●○○
    5-MeO-DMT
    85% ●○○
    2C-B
    65% ●○○
    2C-E
    65% ●○○
    2C-I
    65% ●○○

    Experience Report Analysis

    Erowid
    36 Reports
    1999–2023 Date Range
    18 With Age Data
    26 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 36 experience reports (36 Erowid)

    36 Reports
    26 Effects Detected
    9 Positive
    9 Adverse
    8 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Positive Effects 9

    Empathy 61.1% 70%
    Color Enhancement 61.1% 70%
    Music Enhancement 58.3% 70%
    Euphoria 52.8% 70%
    Stimulation 50.0% 70%
    Introspection 36.1% 70%
    Tactile Enhancement 25.0% 70%
    Focus Enhancement 22.2% 70%
    Creativity Enhancement 11.1% 70%

    Adverse Effects 9

    Anxiety 55.6% 70%
    Confusion 50.0% 70%
    Nausea 33.3% 70%
    Memory Suppression 13.9% 70%
    Pupil Dilation 11.1% 70%
    Thought Loops 8.3% 70%
    Sweating 8.3% 70%
    Psychosis 8.3% 70%
    Motor Impairment 8.3% 70%

    Real-World Dose Distribution

    62K Doses

    From 5 individual dose entries

    Common Combinations

    Most co-occurring substances in experience reports

    Form / Preparation

    Most common forms and preparations reported

    Read full reports on Erowid →
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