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    Quazepam molecular structure

    Quazepam Stats & Data

    Depressant Benzodiazepine
    Doral
    PubChem CID 4999
    NPS DataHub
    MW386.8
    FormulaC17H11ClF4N2S
    CAS36735-22-5
    IUPAC7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepine-2-thione
    SMILESFC(F)(F)CN1C(=S)CN=C(c2ccccc2F)c2cc(Cl)ccc12
    InChIKeyIKMPWMZBZSAONZ-UHFFFAOYSA-N
    2020/3. Benzodiazepine; 2021/3. Benzodiazepine; 2022/3. Benzodiazepine
    Chemical Class Benzodiazepine
    Psychoactive Class Depressant

    Pharmacology

    DrugBank
    Half-life 39 hours State Solid Metabolism Hepatic.

    Description

    Quazepam is a drug which is a benzodiazepine derivative. It induces impairment of motor function and has hypnotic properties. Quazepam is used to treat insomnia.

    Pharmacodynamics

    Quazepam is a benzodiazepine derivative. The main pharmacological action of quazepam is the enhancement of the neurotransmitter GABA at the GABAA receptor.

    Absorption

    Bioavailability is 29-35% following oral administration.

    Indication

    Used to treat insomnia.

    Toxicity

    PubChem

    Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA<sub>A</sub>) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor.

    Carcinogenicity

    No indication of carcinogenicity to humans (not listed by IARC).

    Liver injury risk

    No documented concern

    FDA LiverTox / DILIrank. Reflects published case reports of liver injury, not absolute risk.

    Health effects (PubChem excerpts)

    They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive.

    Effect Profile

    Curated
    Benzodiazepine 7.6

    Strong euphoria and anxiolysis with mild sedation, low cognitive impairment

    Anxiolysis×3
    8
    Sedation / Relaxation×2
    5
    Motor / Cognitive Impairment×1
    1
    Euphoria / Mood Lift×1
    10
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Quazepam

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 3d Half tolerance 37d Baseline ~60d
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