Ro5-4864
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- classified Tentative
- classified Research-chemical
- 4 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 17 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: 4'-chlorodiazepam, 4-chlorodiazepam
Summary
4'-Chlorodiazepam (Ro5-4864) displays nanomolar affinity for the peripheral benzodiazepine receptor/TSPO located on the outer mitochondrial membrane while showing orders-of-magnitude lower affinity for central GABA-A sites. Low-dose TSPO activation can produce neurosteroidogenesis and mild sedation; higher micromolar concentrations become anxiogenic and pro-convulsant in animals. Median convulsive dose (CD₅₀) in mice approximately 42 mg/kg i.p.
Dose Information
Dose basis. Dose ranges are compiled primarily from scattered human anecdotal reports and cautionary community discussions; there are no controlled human PK/PD data. Use a calibrated 0.001 g (1 mg) scale at minimum and strongly consider volumetric dosing to avoid measurement error when working below ~2 mg. Volumetric dosing guidance: dissolve a known mass into a measured volume of an appropriate solvent and dose by volume; see Erowid’s Liquid Measurement Technique for method and pitfalls (solvent choice, evaporation, labeling). (Dose figures and this note are from Drugs.Wiki.)
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 0.5-1.5mg | 1.5-3mg | 3-5mg | 5mg+ (marked seizure risk in animals) |
Onset, Duration & After-effects
| ROA | Onset | Peak | Offset | Total |
|---|---|---|---|---|
| Oral | 20-60 min | 1-3 hrs | 2-3 hrs | 3.33-7 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Moderate sedation with mild anxiolysis, low cognitive impairment
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Ro5-4864 Source: SubstanceSearch (substancesearch.com) Oral dose (mg): threshold 0.25-0.5 · light 0.5-1.5 · common 1.5-3 · strong 3-5 · heavy 5+ (marked seizure risk in animals) Oral duration: onset 0.33-1h · peak 1-3h · offset 2-3h · total 3.33-7h · after-effects 12-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 2.25 mg (Oral).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Rodent literature shows TSPO desensitization over several days of dosing, but human tolerance dynamics are unknown; treat as potentially habit‑forming with partial cross‑tolerance only to other TSPO ligands. Data quality is low and largely theoretical/anecdotal.
Effects
- Muscle Relaxation
- Tremor
- Headache
- Motor impairment
- Mild Sedation
- Sedation
- Reduced anxiety
- Inner Restlessness
- Anxiety Enhancement
- Memory Suppression
- Derealisation
- Tinnitus
- Visual Distortion
- Dulled perception
Combinations
Cross-Check Ro5-4864 with another substanceHelpful Links
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