Summary
Selegiline is a selective, irreversible MAO-B inhibitor at therapeutic doses (5-10 mg/day oral), used for Parkinson's disease and major depressive disorder. At higher doses (>20 mg/day), selectivity is lost and it inhibits both MAO-A and MAO-B, increasing risk of hypertensive crisis with tyramine-rich foods. The transdermal form (Emsam) is used for depression and has less dietary restriction at lower doses due to reduced first-pass metabolism.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Transdermal | 3-6mg/24h | - | - | - |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak |
|---|---|---|---|
| Oral | 60 min | 1-2 hrs | 1-2 hrs |
Effect Profile
15 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
5.6
Strong
6/10
Strong focus with moderate anxiety/jitters, mild stimulation and euphoria
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
4
mood lift
motivation enhancement
Focus / Productivity
×2
9
focus enhancement
cognitive enhancement
memory enhancement
motivation enhancement
Anxiety / Jitters
×1
6
anxiety
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
12d
Baseline
~21d
Effects
Aggregated from 15 Erowid experience reports
Positive Effects 4
Stimulation
53.3%
70%
Euphoria
40.0%
70%
Empathy
26.7%
70%
Focus Enhancement
20.0%
70%
Adverse Effects 2
Anxiety
46.7%
70%
Increased Heart Rate
20.0%
70%
Combinations
Pill Identifiers
6
known pill identifiers on record — view imprints, colors, shapes, and images
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Selegiline's nerd page
Pharmacology, chemical data, effect profiles, and more
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