I'd like to write a bit on selegiline (deprenyl). I'm a 26 year old 83 kg male from Istanbul. Sorry for my (probably) bad English. I've been using the brand name drug SELDEPAR for about 3 weeks. I've been taking about 2.5 mg every day. Some days I took 5 mg, some days none.
Selegiline
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 3 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Aliases: Emsam, Jumex, Zelapar, Anipryl, Deprenyl
Summary
Selegiline is a selective, irreversible MAO-B inhibitor at therapeutic doses (5-10 mg/day oral), used for Parkinson's disease and major depressive disorder. At higher doses (>20 mg/day), selectivity is lost and it inhibits both MAO-A and MAO-B, increasing risk of hypertensive crisis with tyramine-rich foods. The transdermal form (Emsam) is used for depression and has less dietary restriction at lower doses due to reduced first-pass metabolism.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 2-5mg | 5-10mg | 10-30mg | 30mg+ |
| Transdermal | 3-6mg/24h | - | - | - |
| Sublingual | 0.6-1mg | 1-3mg | 3-6mg | 6mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Total |
|---|---|---|---|---|
| Oral | 30-60 min | - | - | 6-24 hrs |
| Transdermal | - | 6-12 hrs | 6-12 hrs | - |
| Sublingual | 15-30 min | - | - | 6-24 hrs |
Effect Profile
15 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
5.6
Strong
6/10
Strong focus with moderate anxiety/jitters, mild stimulation and euphoria
Stimulation / Energy
×3
5
stimulation
wakefulness
Euphoria / Mood Lift
×2
4
mood lift
motivation enhancement
Focus / Productivity
×2
9
focus enhancement
cognitive enhancement
memory enhancement
motivation enhancement
Anxiety / Jitters
×1
6
anxiety
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
12d
Baseline
~21d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 15 Erowid experience reports
Positive Effects 4
Stimulation
53.3%
70%
Euphoria
40.0%
70%
Empathy
26.7%
70%
Focus Enhancement
20.0%
70%
Adverse Effects 2
Anxiety
46.7%
70%
Increased Heart Rate
20.0%
70%
Combinations
Cross-Check Selegiline with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 7 reports 6 neutral 1 cautionary visit
First off, I'm a 19 year old male, about 170lbs, who is experimenting with nootropics out of curiosity. A few months ago, I ordered a bottle with 60 doses of 5mg Selegiline from a research chemical site and took it pretty much every day. The day I started taking it I noticed a marked increase in motivation.
After 42 years I had to face the sometimes debilitating depression that was affecting my ability to function. Rather than see a conventional MD I found a clinical researcher that was testing new drug therapies as part of FDA approvals.
The problem with legal drugs is that there's usually not much to talk about. Deprenyl is similar to an extent. I've experienced nothing truly unusual while using this product. I began taking Deprenyl as an anti-aging agent and a smart drug.
I'll be 60 years old next month and have been using Deprenyl for about the past 10 years. In most respects it's difficult to quantify the effects of this compound: in terms of its reputed anti-aging benefits I can say that I am very active, never get sick and am still alive.
Well, I tried deprenyl as a 'smart drug' years ago and I also did it 'recreationally'. Tried it as a smart drug while I was taking some classes and couldn't handle it for that purpose as it overstimulated me and caused insomnia. I Did the rest of my supply 'recreationally' over the next few years.
I have depression, anxiety, social anxiety, OCD. I have tried many medicines the doctors have given me. One day my doctor gave me a box of EMSAM patches, 9 mg each. I tried them for a couple months, one a day, and I felt nothing. No improvement was evident, I felt just as tired and anxious as always.
Bluelight 2 threads 2 neutral visit
Alright, so I've been uber-curious about this mysterious substance for quite some time now. Everything I have read about this drug on BL has been excellent, so I decided to give it a shot to see how well it does as an anti-depressant.
Howdy folks, Long time lurker, though I rarely post so I apologize if Trip Reports is a more appropriate place for this post. I've seen a few threads on the PEA-Deprenyl combination, but no hard proof or first hand info. So here's a bit from the perspective of someone who's tried it all.
Pill Identifiers
6
known pill identifiers on record — view imprints, colors, shapes, and images
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Selegiline's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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