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    Disclaimer
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.
    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    SL-164 Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 2 ROAs with full dose ladders
    • duration data present
    • 17 combo interactions documented
    • classified Research-chemical
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Dcq

    Depressant Research-chemical Benzodiazepine

    Summary dose.wiki

    Case reports and user accounts highlight a pronounced tendency toward myoclonic twitching and seizures, especially above approximately 200 mg or when combined with other CNS depressants; emergency benzodiazepines are advised to manage convulsions. Illicit samples may contain residues of the synthesis precursor 4-chloro-o-toluidine, which can cause methemoglobinemia and hematuria. Users report effects similar to GHB and carisoprodol with notable euphoria and muscle relaxation, but seizure risk limits therapeutic potential.

    Dose Information dose.wiki Drugs.Wiki

    Dose basis. Dose bands are compiled from user reports and forum accounts, not clinical data; individual sensitivity varies widely. Start with an allergy test (1–2 mg) and use a calibrated milligram scale; consider volumetric dosing for accuracy. Redosing within 2 hours increases risk because of delayed onset and stacking. Evidence base: community reports and general HR guidance. Reports describe marked nasal irritation (“burning/like chlorine”), inconsistent absorption, and more abrupt adverse effects (tremor/jerks). Insufflation is discouraged for this compound. Evidence base: user reports. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-250mg 250-400mg 400mg+
    Insufflated 30-60mg 60-120mg 120-200mg 200mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 30-60 min 15-30 min 45 min 1-2 hrs 2-8 hrs 2.5-4.25 hrs
    Insufflated 15-30 min 10-20 min 30 min 1-2 hrs 2-8 hrs 1.92-3.33 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Benzodiazepine 7.1
    Strong+ 7/10

    Strong anxiolysis, cognitive impairment, and euphoria with mild sedation

    Anxiolysis ×3
    10
    anxiolysis anxiety suppression anxiolytic muscle relaxation
    Sedation / Relaxation ×2
    5
    sedation muscle relaxation
    ⚠ Motor / Cognitive Impairment ×1
    10
    motor control loss ataxia amnesia memory suppression double vision
    Euphoria / Mood Lift ×1
    10
    euphoria cognitive euphoria physical euphoria disinhibition
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track SL-164 there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "SL-164 (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    SL-164
    Unit
    mg
    Description 
    SL-164
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 30 · light 50-100 · common 100-250 · strong 250-400 · heavy 400+
Insufflated dose (mg): threshold 20 · light 30-60 · common 60-120 · strong 120-200 · heavy 200+

Oral duration: onset 0.5-1h · come-up 15-30m · peak 45m · offset 1-2h · total 2.5-4.25h · after-effects 2-8h
Insufflated duration: onset 15-30m · come-up 10-20m · peak 30m · offset 1-2h · total 1.92-3.33h · after-effects 2-8h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 175 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset weeks to months depending on half-life and duration of use; taper recommended

    Tolerance Decay

    Full tolerance 3d Half tolerance 14d Baseline ~60d

    Patterns inferred from sedative-hypnotic class (methaqualone/benzodiazepines) and anecdotal reports of rapid tolerance; figures are heuristic and low confidence. Space uses by multiple days to reduce risk.

    Cross-Tolerances

    methaqualone
    60%
    benzodiazepines
    40%
    barbiturates
    40%
    Z-drugs
    30%

    Effects dose.wiki

    Positive
    • Physical euphoria
    • Anxiolysis
    • Muscle relaxation
    • Anxiolytic
    Negative
    • Ataxia
    • Myoclonic twitching
    • Seizures
    • Respiratory depression
    Neutral
    • Sedation
    • Sedative
    Positive
    • Euphoria
    • Anxiety suppression
    • Dream potentiation
    • Cognitive euphoria
    Negative
    • Motor control loss
    • Dizziness
    • Amnesia
    • Memory suppression
    • Delirium
    • Thought deceleration
    Positive
    • Tactile enhancement
    • Increased libido
    Negative
    • Disinhibition
    • Acuity suppression
    • Double vision
    Neutral
    • Dulled perception
    • Visual disconnection
    • Internal hallucination
    • Changes in gravity
    • Internal hallucinations

    Combinations

    Cross-Check SL-164 with another substance

    SL-164's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki