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    Disclaimer
    ☠ This is a fentanyl analogue active in microgram doses. Accidental overdose can be rapidly fatal. Naloxone should always be on hand.

    Sufentanil

    Aliases: Dsuvia, Sufenta, Chronogesic

    Depressant Opioid

    Summary PsychonautWiki

    Sufentanil, also known as sufentanyl and by the brand name Sufenta, is an extremely potent synthetic anilidopiperidine opioid analgesic. Sufentanil has a rapid onset and short mechanism and is used medically as an analgesic in surgical procedures or for the management of post-operative pain. Sufentanil is roughly 500 to 1,000 times more potent than pharmaceutical grade morphine and is approximately 10 times more potent than pharmaceutical grade fentanyl.

    Dose Information TheDrug.Wiki TripSit PsychonautWiki

    ROA Light Common Strong Heavy
    Intravenous 1-5μg 5-10μg 10-25μg 25μg+
    Sublingual 1-5ug 5-10ug 10-25ug 25µg+
    Oral 1-5ug 5-10ug 10-25ug 25ug+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit PsychonautWiki

    ROA Onset Peak Offset After Effects Total
    Intravenous 1-2 min 5-10 min 15-30 min 1-12 hrs 21-42 min
    Epidural 5-15 min 30-60 min 1-2 hrs 2-8 hrs 1.58-3.25 hrs
    Sublingual 10-30 min 60-90 min 1-2 hrs 2-8 hrs 2.17-4 hrs
    Oral 1-2 min 5-10 min - 1-12 hrs 6-12 min

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Opioid 6.7
    Strong+ 7/10

    Strong euphoria and sedation with moderate itching/nausea, mild pain relief

    Euphoria / Warmth ×3
    9
    physical euphoria cognitive euphoria euphoria
    Analgesia ×2
    4
    pain relief
    Sedation / Relaxation ×1
    8
    sedation drowsiness muscle relaxation dream potentiation
    ⚠ Itching / Nausea ×1
    6
    nausea constipation
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Sufentanil
    View methodology →

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset 7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk

    Tolerance Decay

    Full tolerance 1d Half tolerance 21d Baseline ~35d

    Effects TheDrug.Wiki

    Positive
    • Pain Relief
    • Physical Euphoria
    • Cough Suppression
    • Muscle Relaxation
    Negative
    • Respiratory Depression
    • Nausea
    Neutral
    • Sedation
    • Difficulty Urinating
    • Itchiness
    • Pupil Constriction
    Positive
    • Anxiety Suppression
    • Reduced anxiety
    • Cognitive Euphoria
    • Dream Potentiation
    • Euphoria
    • Feelings of relaxation
    Negative
    • Constipation
    • Compulsive Redosing
    • Drowsiness
    Neutral
    • Changes in focus
    Negative
    • Decreased Libido
    • Dehydration
    • Double Vision
    • Appetite Suppression
    • Orgasm Suppression
    • Orgasm depression
    • Acuity Suppression
    • Disinhibition
    • Light sensitivity
    Neutral
    • Dulled perception

    Combinations TripSit

    Sufentanil's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

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