Tesofensine
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
- 1 source
- duration data present
- classified Research-chemical
- dose data not in PW/TripSit (unverifiable)
Aliases: Te, Ns-2330
Summary
Tesofensine is a triple-monoamine reuptake inhibitor originally developed for neurodegenerative disorders but repurposed for obesity treatment. Clinical pharmacokinetics show an elimination half-life of ≈220 hours with an active N-desalkyl metabolite (NS2360) lasting ≈374 hours; steady-state is reached only after 4-5 weeks. Single overdoses can linger for over a week.
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 0.5-2 hrs | 2-4 hrs | 4-10 hrs | 12-24 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong anxiety/jitters with moderate focus, mild euphoria and stimulation
Tolerance
Tolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
- Mental Stimulation
- Dry Mouth
- Insomnia
- Tachycardia
- Diarrhea
- Nausea
- Headache
- Teeth Grinding
- Vasoconstriction
- Increased Heart Rate
- Motivation Enhancement
- Focus Enhancement
- Alertness enhancement
- Cognitive Euphoria
- Increased Sociability
- Anxiety
- Constipation
- Protracted Comedown
- Talkativeness
- Thought Acceleration
- Increased Libido
- Increased music appreciation
- Color enhancement
- Appetite Suppression
- Light sensitivity
- Disinhibition
- Appetite suppression
- Dehydration
- Dulled perception
- Drifting
Helpful Links
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