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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Tesofensine

    Aliases: Te, Ns-2330

    Stimulant Research-chemical

    Summary TheDrug.Wiki

    Tesofensine is a triple-monoamine reuptake inhibitor originally developed for neurodegenerative disorders but repurposed for obesity treatment. Clinical pharmacokinetics show an elimination half-life of ≈220 hours with an active N-desalkyl metabolite (NS2360) lasting ≈374 hours; steady-state is reached only after 4-5 weeks. Single overdoses can linger for over a week.

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 0.5-2 hrs 2-4 hrs 4-10 hrs 12-24 hrs 24-72 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.5
    Moderate 4/10

    Strong anxiety/jitters with moderate focus, mild euphoria and stimulation

    Stimulation / Energy ×3
    4
    mental stimulation alertness enhancement
    Euphoria / Mood Lift ×2
    5
    cognitive euphoria motivation enhancement
    Focus / Productivity ×2
    7
    focus enhancement motivation enhancement thought acceleration
    ⚠ Anxiety / Jitters ×1
    10
    anxiety tachycardia teeth grinding increased heart rate vasoconstriction
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Tesofensine
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute tolerance; longer for full reset

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Effects TheDrug.Wiki

    Positive
    • Mental Stimulation
    Negative
    • Dry Mouth
    • Insomnia
    • Tachycardia
    • Diarrhea
    • Nausea
    • Headache
    • Teeth Grinding
    • Vasoconstriction
    • Increased Heart Rate
    Positive
    • Motivation Enhancement
    • Focus Enhancement
    • Alertness enhancement
    • Cognitive Euphoria
    • Increased Sociability
    Negative
    • Anxiety
    • Constipation
    • Protracted Comedown
    Neutral
    • Talkativeness
    • Thought Acceleration
    Positive
    • Increased Libido
    • Increased music appreciation
    • Color enhancement
    Negative
    • Appetite Suppression
    • Light sensitivity
    • Disinhibition
    • Appetite suppression
    • Dehydration
    Neutral
    • Dulled perception
    • Drifting
    Tesofensine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki