Summary
Tesofensine is a triple-monoamine reuptake inhibitor originally developed for neurodegenerative disorders but repurposed for obesity treatment. Clinical pharmacokinetics show an elimination half-life of ≈220 hours with an active N-desalkyl metabolite (NS2360) lasting ≈374 hours; steady-state is reached only after 4-5 weeks. Single overdoses can linger for over a week. Community reports emphasize starting at ≤0.25 mg every 48 hours to limit insomnia, anxiety, and heart rate increases (8-15 bpm above baseline). Research chemical vendor authenticity varies; reagent testing with TLC plus chiral GC-MS is advised.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 0.5-2 hrs | 2-4 hrs | 4-10 hrs | 12-24 hrs | 24-72 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Effects
Positive
- Mental Stimulation
Negative
- Dry Mouth
- Insomnia
- Tachycardia
- Diarrhea
- Nausea
- Headache
- Teeth Grinding
- Vasoconstriction
- Increased Heart Rate
Positive
- Motivation Enhancement
- Focus Enhancement
- Alertness enhancement
- Cognitive Euphoria
- Increased Sociability
Negative
- Anxiety
- Constipation
- Protracted Comedown
- Talkativeness
- Thought Acceleration
Positive
- Increased Libido
- Increased music appreciation
- Color enhancement
Negative
- Appetite Suppression
- Light sensitivity
- Disinhibition
- Appetite suppression
- Dehydration
- Dulled perception
- Drifting