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    Tesofensine molecular structure

    Tesofensine Stats & Data

    Stimulant Research-chemical
    Te Ns-2330
    NPS DataHub
    MW328.28
    FormulaC17H23Cl2NO
    CAS195875-84-4
    IUPAC(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane
    SMILESCCOCC1C2CCC(CC1c1ccc(Cl)c(Cl)c1)N2C
    InChIKeyVCVWXKKWDOJNIT-ZOMKSWQUSA-N
    Psychoactive Class Stimulant

    Pharmacology

    DrugBank
    State Solid

    Mechanism of Action

    Tesofensine is a Serotonin-norepinephrine-dopamine-reuptake-inhibitor (SNDRI). SNDRIs are a class of psychoactive antidepressants. They act upon neurotransmitters in the brain, namely, serotonin, norepinephrine and dopamine. These three biogenic monoamines are associated with depression and increasing the availability in the brain is one method used to treat the condition.

    Indication

    Investigated for use/treatment in alzheimer's disease, parkinson's disease, and obesity.

    Effect Profile

    Curated
    Stimulant 4.5

    Strong anxiety/jitters with moderate focus, mild euphoria and stimulation

    Stimulation / Energy×3
    4
    Euphoria / Mood Lift×2
    5
    Focus / Productivity×2
    7
    Anxiety / Jitters×1
    10
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Tesofensine

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d
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