THCV
Summary
Cannabis (also known as THC, marijuana, weed, pot, grass, hemp, and many others) is a preparation of the cannabis plant that produces psychoactive effects when consumed (via smoking, vaporizing, or ingestion). It is the most used illicit substance in the world. The mechanism of action is binding activity at cannabinoid receptors distributed throughout the body.
Tolerance
Build-up
develops over weeks of regular use via CB1 receptor downregulation
Reset
2–4 weeks for most users; heavy users may need longer
Tolerance Decay
Full tolerance
3d
Half tolerance
21d
Baseline
~28d
Effects
Positive
- Pain relief
- Anxiolysis
Negative
- Nausea
- Dry mouth
- Increased heart rate
- Tachycardia
- Nausea/vomiting
- Sedation
- Spontaneous bodily sensations
- Vasodilation
Positive
- Euphoria
- Anxiety suppression
- Thought connectivity
- Reduced anxiety
Negative
- Anxiety
- Paranoia
- Motor control loss
- Short-term memory suppression
- Psychosis
- Time distortion
Positive
- Color enhancement
- Increased music appreciation
- Appetite enhancement
- Auditory acuity enhancement
Negative
- Dehydration
- Dulled perception
- Visual distortions
- Appetite intensification
- Changes in felt gravity
- Perception of bodily heaviness
Combinations
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