Psychoactive Class
Stimulant
Receptor Profile
Receptor Actions
Antagonists
Adenosine receptor antagonist (competitive inhibitor)
Other
affects dopamine, acetylcholine, and serotonin receptors
at high doses affects norepinephrine receptors
to a lesser extent affects epinephrine, glutamate, and cortisol
Effect Profile
Curated
Stimulant
6.4
Strong focus and anxiety/jitters with moderate euphoria, mild stimulation
Stimulation / Energy×3
5
Euphoria / Mood Lift×2
7
Focus / Productivity×2
10
Anxiety / Jitters×1
8
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
References
Data Sources
Cited References
- Feduccia et al. (2012): Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine
- He et al. (2017): Assessment of Drug-Drug Interaction Potential Between Theacrine and Caffeine
- Kuhman et al. (2015): Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement
- PsychonautWiki: Theacrine
- RxList: Theacrine Health Benefits and Side Effects
- Scientific Reports (2024): Dose Response Effects of Theacrine on Cognitive Performance and Sleep
- SelfDecode: 3 Potential Benefits of Theacrine
- Wang et al. (2010): Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities
- WebMD: Theacrine Overview
- Nootropics Depot: TeaCrine Guide