Theacrine Stats & Data
QGDOQULISIQFHQ-UHFFFAOYSA-NPharmacology
DrugBankReceptor Profile
Receptor Actions
Toxicity
PsychonautWikiTheacrine is not known to cause brain damage, and has an extremely low toxicity relative to dose. There are relatively few physical side effects associated with theacrine exposure. Various studies have shown that in reasonable doses in a careful context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort. It is strongly recommended that one use harm reduction practices when using this drug.
Effect Profile
CuratedStrong focus and anxiety/jitters with moderate euphoria, mild stimulation
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
References
Data Sources
Cited References
- Feduccia et al. (2012): Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine
- He et al. (2017): Assessment of Drug-Drug Interaction Potential Between Theacrine and Caffeine
- Kuhman et al. (2015): Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement
- PsychonautWiki: Theacrine
- RxList: Theacrine Health Benefits and Side Effects
- Scientific Reports (2024): Dose Response Effects of Theacrine on Cognitive Performance and Sleep
- SelfDecode: 3 Potential Benefits of Theacrine
- Wang et al. (2010): Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities
- WebMD: Theacrine Overview
- Nootropics Depot: TeaCrine Guide