Thiopropamine
Aliases: Tpa, Normethiopropamine, A-methyl-2-thipheneethanamine
Summary
A substance that is closely related to Methiopopramine (MPA). Is roughly about 1/3rd the potency of amphetamine, differs from amphetmine from the phenyl ring is switched with a thiophene ring.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 20-50mg | 50-100mg | 100-125mg | 125mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak |
|---|---|---|
| Oral | 15-45 min | 1-4 hrs |
Effect Profile
Scores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
4.5
Moderate
4/10
Strong anxiety/jitters and euphoria with moderate stimulation
Stimulation / Energy
×3
6
stimulation
wakefulness
alertness enhancement
Euphoria / Mood Lift
×2
9
physical euphoria
cognitive euphoria
euphoria
Focus / Productivity
×2
0
Anxiety / Jitters
×1
10
anxiety
increased heart rate
teeth grinding
vasoconstriction
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute tolerance; longer for full reset
Tolerance Decay
Full tolerance
1d
Half tolerance
10d
Baseline
~18d
Effects
Positive
- Stimulation
- Physical euphoria
- Muscle relaxation
Negative
- Increased heart rate
- Nausea
- Vasoconstriction
- Respiratory depression
- Teeth grinding
- Insomnia
- Sedation
Positive
- Alertness enhancement
- Cognitive euphoria
- Euphoria
- Anxiety suppression
- Wakefulness
Negative
- Anxiety
- Compulsive redosing
- Dizziness
- Talkativeness
- Time distortion
Positive
- Increased music appreciation
- Increased libido
- Tactile enhancement
- Color enhancement
Negative
- Light sensitivity
- Disinhibition
- Appetite suppression
- Dehydration
- Double vision
- Dulled perception
Thiopropamine's nerd page
Pharmacology, chemical data, effect profiles, and more
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