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    Thiopropamine molecular structure

    Thiopropamine Stats & Data

    Tpa Normethiopropamine A-methyl-2-thipheneethanamine
    NPS DataHub
    MW141.24
    FormulaC7H11NS
    CAS30433-93-3
    IUPAC1-thiophen-2-ylpropan-2-amine
    SMILESCC(N)Cc1cccs1
    InChIKeyNYVQQTOGYLBBDQ-UHFFFAOYSA-N
    Phenethylamines; 2020/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2021/1. Von 2-Phenethylamin abgeleitete Verbindungen; 2022/1. Von 2-Phenethylamin abgeleitete Verbindungen
    Psychoactive Class Stimulant

    Pharmacology

    DrugBank
    State Liquid

    Description

    Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells

    Mechanism of Action

    Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.

    Pharmacodynamics

    Alteplase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin. It also produces limited conversion of plasminogen in the absence of fibrin.

    Indication

    For management of acute myocardial infarction, acute ischemic stroke and for lysis of acute pulmonary emboli.

    History & Culture

    Thiopropamine was first synthesized in 1942, though it remained obscure for over seven decades before entering the recreational drug market. The compound only emerged commercially in early 2016, appearing shortly after regulatory action was taken against the structurally related substance MPA (methiopropamine) in the United Kingdom. The timing of thiopropamine's market entry proved historically unfavorable, arriving just weeks before broader legislative changes would restrict its commercial availability. As a result, the substance is generally regarded as a minor footnote in the history of novel psychoactive substances, having entered the scene too late to establish significant cultural presence during the final period of the legal high era.

    Effect Profile

    Curated
    Stimulant 4.5

    Strong anxiety/jitters and euphoria with moderate stimulation

    Stimulation / Energy×3
    6
    Euphoria / Mood Lift×2
    9
    Focus / Productivity×2
    0
    Anxiety / Jitters×1
    10

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1d Half tolerance 10d Baseline ~18d

    Legal Status

    Country Status Notes
    United Kingdom Psychoactive Substances Act 2016 Sale and import became prohibited following the implementation of the Psychoactive Substances Act in May 2016. Notably, personal possession is not criminalized under this legislation. Thiopropamine appeared on the UK market in early 2016, shortly before the Act came into force.
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