The country I live has Stablon (tianeptine) available without prescription from pharmacies. After some research, I decided to try it out. First, I took 3 tabs (12,5mg each), max. daily dosage, and noticed a slight headache after 30 mins, which is average onset time.
Tianeptine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 5 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki)
- classified Research-chemical
Aliases: Zaza, Coaxil, Stablon, Tatinol, Pegasus
Summary
Tianeptine (trade names Stablon and Coaxil) is an atypical antidepressant. While primarily a prescription drug, it is sometimes used in high doses for recreational opioid effects. It has a unique and poorly-understood mechanism of action consisting of modulation of the brain's monoaminergic and glutamatergic systems.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~99% | 6-12mg | 12-35mg | 35-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 15-30 min | 60-90 min | 30-60 min | 2-3 hrs |
| Intravenous | <1-1 min | 0-36 sec | 10-30 min | 1-2 hrs | 4-6 hrs |
Effect Profile
17 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.0
Moderate+
5/10
Moderate euphoria and itching/nausea with mild sedation and pain relief
Euphoria / Warmth
×3
6
physical euphoria
cognitive euphoria
Analgesia
×2
4
analgesia
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Tianeptine, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
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Import this file as custom substances
and you get "Tianeptine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Dose & duration (reference)
Tianeptine: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Intravenous dose (mg): threshold 5-10 Intravenous duration: onset <1-1m · come-up 0-36s · peak 10-30m · offset 1-2h · total 4-6h · after-effects 6-24h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Aggregated from 17 Erowid experience reports
Positive Effects 10
Euphoria
52.9%
70%
Sedation
47.1%
70%
Stimulation
47.1%
70%
Empathy
35.3%
70%
Anxiety Suppression
35.3%
70%
Color Enhancement
23.5%
70%
Music Enhancement
23.5%
70%
Tactile Enhancement
23.5%
70%
Focus Enhancement
23.5%
70%
Introspection
17.6%
70%
Adverse Effects 2
Nausea
23.5%
70%
Headache
17.6%
70%
Combinations
Cross-Check Tianeptine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 4 neutral 4 cautionary visit
I'm a big fan of opiates. Ever since I tried some hydrocodone about seven years ago, I've been enjoying experimenting with different opiates, and spending considerable time taking them.
This experience was mostly pleasant. To provide a baseline, I started off the night with one drink but otherwise was completely sober and have not used any other drugs or medications in months. I was curious to try Tianeptine because it has been banned in my home state, which of course adds an appeal for some people.
Tianeptine Is Weird I've gotten my hands on some tianeptine sulfate and tianeptine sodium this last month. There is quite a difference between the two in terms of the acute side effects. This is about my experience with tianeptine sodium.
BACKGROUND: I have a long and torrid history with antidepressants. I spent 9 years on SSRI's, SNRI's, atypicals, tricyclics and even Risperdal in a vain attempt to treat depression. No such luck.
I've been taking Tianeptine now for about 5 months, with a break of about one month after the second. I've taken Fluoxetine (Prozac), Buspirone (Buspar), and (Buproprion) Wellbutrin, all of which helped in varying degrees but had side-effects that outweighed the benefit for me.
I wanted to provide some insight for the benefit of others due to the surprising scarcity of information regarding this drug -- so I appreciate anyone taking the time to read my thoughts on the matter.
Ill try to make this long story short. After 2 years of a barrage of anti-depressants totally fucked up my psyche permanently, I took something I did occasionally for fun (hydrocodone) and made it a daily habit. Got off, went through withdrawals. Months later, me and girlfriend back on.
Bluelight 2 threads 2 neutral visit
Ok, there's not a ton of information out there on this substance so I figured that I would put together my experience with it as it's a very particular substance with unique properties and definite recreational potential.
I've done most of the opioids and other drugs. I read about Tianeptine on BL and decided to order some. Let me say this shit is pretty damn good, and cheap compared to other drugs. I came home from work tonight and the package was waiting in the mail.
Tianeptine's nerd page
Pharmacology, chemical data, effect profiles, and more
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