Tianeptine
Aliases: Zaza, Coaxil, Stablon, Tatinol, Pegasus
Categories
Summary
Tianeptine is prescribed therapeutically at 12.5 mg three times daily, but recreational use involves doses 10-100x higher. The short half-life and duration promote frequent redosing and rapid tolerance buildup. Despite animal studies suggesting minimal tolerance, human reports consistently describe severe withdrawal similar to traditional opioids. Naloxone reverses overdose; buprenorphine or methadone protocols are effective for withdrawal management. Multiple U.S.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~99% | 6-12mg | 12-35mg | 35-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 30-60 min | 15-30 min | 60-90 min | 30-60 min | 6-24 hrs | 120-0 min |
| Intravenous | 0-0 min | 0-1 min | 10-30 min | 1-2 hrs | 6-24 hrs | 240-0 min |
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Effects
Positive
- Physical Euphoria
- Stimulation
- Muscle Relaxation
- Bronchodilation
- Analgesia
Negative
- Nausea
- Headaches
- Physical Fatigue
- Respiratory Depression
- Sedation
- Itchiness
Positive
- Cognitive Euphoria
- Motivation Enhancement
- Anxiety Suppression
- Focus Enhancement
- Rejuvenation
Negative
- Thought Deceleration
- Constipation
- Dizziness
- Cognitive Fatigue
- Thought Acceleration
- Ego Inflation
Positive
Negative
- Dehydration
- Light sensitivity
- Disinhibition
- Appetite Suppression
- Decreased Libido
- Orgasm Suppression
- Internal Hallucination
- Dulled perception
- Appetite intensification
- Appetite change