Tianeptine
Aliases: Zaza, Coaxil, Stablon, Tatinol, Pegasus
Summary
Tianeptine (trade names Stablon and Coaxil) is an atypical antidepressant. While primarily a prescription drug, it is sometimes used in high doses for recreational opioid effects. It has a unique and poorly-understood mechanism of action consisting of modulation of the brain's monoaminergic and glutamatergic systems.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~99% | 6-12mg | 12-35mg | 35-100mg | 100mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 30-60 min | 15-30 min | 60-90 min | 30-60 min | 2.2-4 hrs |
Effect Profile
17 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
5.0
Moderate+
5/10
Moderate euphoria and itching/nausea with mild sedation and pain relief
Euphoria / Warmth
×3
6
physical euphoria
cognitive euphoria
Analgesia
×2
4
analgesia
Sedation / Relaxation
×1
5
sedation
muscle relaxation
Itching / Nausea
×1
6
nausea
constipation
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
7–14 days for partial reset; full reset may take weeks — tolerance loss greatly increases overdose risk
Tolerance Decay
Full tolerance
1d
Half tolerance
21d
Baseline
~35d
Effects
Aggregated from 17 Erowid experience reports
Positive Effects 10
Euphoria
52.9%
70%
Sedation
47.1%
70%
Stimulation
47.1%
70%
Empathy
35.3%
70%
Anxiety Suppression
35.3%
70%
Color Enhancement
23.5%
70%
Music Enhancement
23.5%
70%
Tactile Enhancement
23.5%
70%
Focus Enhancement
23.5%
70%
Introspection
17.6%
70%
Adverse Effects 2
Nausea
23.5%
70%
Headache
17.6%
70%
Combinations
Tianeptine's nerd page
Pharmacology, chemical data, effect profiles, and more
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