TMA
Aliases: Tma-1, 3,4,5-tma, Ξ-methylmescaline, Mescalamphetamine
Summary
TMA is a rare synthetic psychedelic amphetamine and the alpha-methylated analog of mescaline. Effects are generally less visual and less euphoric than mescaline, with more unpredictable emotional responses. At higher doses (above 200 mg), Shulgin's research documented potentially antisocial behavioral changes including anger and hostility, which were not observed with mescaline.
Perspectives
“I had no nausea, although I always vomit with mescaline. Somehow my personality was divided and exposed, and this allowed me to understand my psychic structure more clearly. But maybe others could look in there, too. The psychiatric use of this drug would be interesting to pursue. It is not completely pleasant, maybe because of this personal intimacy.”
“TMA provided an interesting and insightful low-level psychedelic experience with manageable but noticeable bodyload.”
Dose Information
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset |
|---|---|---|---|---|
| Oral | 1.5-2 hrs | 30-60 min | 3-5 hrs | 2-3 hrs |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Strong headspace with moderate visuals, mild auditory effects and body load
Strong euphoria and anxiety/jitters with low stimulation
Tolerance
Tolerance Decay
Tolerance and cross-tolerance estimates inferred from mescaline and classical psychedelic literature; human TMA-specific data are sparse. Conservative spacing of 7β14 days reduces blunted effects.
Cross-Tolerances
Effects
Aggregated from 3 Erowid experience reports
Positive Effects 1
Adverse Effects 1
Combinations
PiHKAL / TiHKAL
“I had no nausea, although I always vomit with mescaline. Somehow my personality was divided and exposed, and this allowed me to understand my psychic structure more clearly. But maybe others could look in there, too. The psychiatric use of this drug would be interesting to pursue. It is not completely pleasant, maybe because of this personal intimacy.”