Title: A taste of mescalin's rare and strange amphetamine homologue. I didnΒt change much from the original notes I made during the trip so you have a better understanding of how I felt during the trip. My conclusion and short TL;DR is at the bottom.
TMA
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- classified Research-chemical
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 3 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 20 combo interactions documented
- classified Research-chemical
Aliases: Tma-1, 3,4,5-tma, Ξ-methylmescaline, Mescalamphetamine
Summary
TMA is a rare synthetic psychedelic amphetamine and the alpha-methylated analog of mescaline. Effects are generally less visual and less euphoric than mescaline, with more unpredictable emotional responses. At higher doses (above 200 mg), Shulgin's research documented potentially antisocial behavioral changes including anger and hostility, which were not observed with mescaline.
Perspectives
“I had no nausea, although I always vomit with mescaline. Somehow my personality was divided and exposed, and this allowed me to understand my psychic structure more clearly. But maybe others could look in there, too. The psychiatric use of this drug would be interesting to pursue. It is not completely pleasant, maybe because of this personal intimacy.”
“TMA provided an interesting and insightful low-level psychedelic experience with manageable but noticeable bodyload.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 70-140mg | 140-170mg | 170-200mg | 200mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
6.9
Strong+
7/10
Strong headspace with moderate visuals, mild auditory effects and body load
Visual Intensity
×3
7
color enhancement
drifting
tracers
pattern recognition enhancement
Headspace Depth
×3
8
conceptual thinking
introspection
emotion enhancement
time distortion
confusion
Auditory Effects
×1
4
auditory distortion
Body Load / Somatic Effects
×1
4
nausea
increased heart rate
Stimulant
3.6
Moderate
4/10
Strong euphoria and anxiety/jitters with low stimulation
Stimulation / Energy
×3
3
stimulation
Euphoria / Mood Lift
×2
9
physical euphoria
cognitive euphoria
euphoria
Focus / Productivity
×2
0
Anxiety / Jitters
×1
8
anxiety
restlessness
increased heart rate
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3β7 days for acute; 1β3 weeks for full reset
Tolerance Decay
Full tolerance
2d
Half tolerance
3d
Baseline
~21d
Acute tolerance: develops within a single session β the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Tolerance and cross-tolerance estimates inferred from mescaline and classical psychedelic literature; human TMA-specific data are sparse. Conservative spacing of 7β14 days reduces blunted effects.
Cross-Tolerances
Effects
Aggregated from 3 Erowid experience reports
Positive Effects 1
Music Enhancement
100.0%
70%
Adverse Effects 1
Nausea
100.0%
70%
Combinations
Cross-Check TMA with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 2 reports 2 neutral visit
[This report originally appeared as handwritten notes in Book 1, pages 9-12 of the Shulgin Lab Books.] Objective Response to TMA Date: 4/22/60 Subjects: Gladys, Hugh, Irving Observer: Alexander Shulgin DOSE see page 2. no antiametic administered. _______________________ [TEXT FROM 'PAGE 2'] 4/22/60. Subjects.
Bluelight 2 threads 2 neutral visit
There was not a lot of information publicly available about the effects of the compound: all I cound find was pihkal, a few articles from the 1950's/1960's and some google-translated reports from the book βpsychedelische chemieβ.
Hello all, I am sorry that I have not been able to produce a substance of the month for a long time. I have been on the verge of moving to finish my B.S. in Biochemistry.
PiHKAL / TiHKAL
PiHKAL #157: TMA
“I had no nausea, although I always vomit with mescaline. Somehow my personality was divided and exposed, and this allowed me to understand my psychic structure more clearly. But maybe others could look in there, too. The psychiatric use of this drug would be interesting to pursue. It is not completely pleasant, maybe because of this personal intimacy.”
TMA's nerd page
Pharmacology, chemical data, effect profiles, and more
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