Summary
3,4,5-Trimethoxyphenethylamine (also known as mescaline) is a naturally-occurring classical psychedelic substance of the phenethylamine class. It occurs naturally in the peyote cactus (Lophophora williamsii), San Pedro cactus (Echinopsis pachanoi), Peruvian Torch cactus (Echinopsis peruviana) as well as the Cactaceae plant and the Fabaceae bean families. It is one of the oldest known hallucinogens and the parent compound of the psychedelic phenethylamines, one of the two major subclasses of psychedelic compounds (along with tryptamines).
Perspectives
“This is a magical substance—it is intricate and complex, with odd little surprises hiding in all of its secret places. Everything is exactly as it should be—the beautiful naivety of youth, manifest as resplendent color and energy.”
“I would have liked to, and was expecting to, have an exciting visual day, but I seemed to be unable to escape self-analysis. At the peak of the experience I was quite intoxicated and hyper with energy, so that it was not hard to move around. I was quite restless. But I spent most of the day in considerable agony, attempting to break through without success. I learned a great deal about myself and my inner workings. Everything almost was, but in the final analysis, wasn’t. I began to become aware of a point, a brilliant white light, that seemed to be where God was entering, and it was inconceivably wonderful to perceive it and to be close to it. One wished for it to approach with all one’s heart. I could see that people would sit and meditate for hours on end just in the hope that this little bit of light would contact them. I begged for it to continue and come closer but it did not. It faded away not to return in that particular guise the rest of the day. Listening to Mozart’s Requiem, there were magnificent heights of beauty and glory. The world was so far away from God, and nothing was more important than getting back in touch with Him. But I saw how we created the nuclear fiasco to threaten the existence of the planet, as if it would be only through the threat of complete annihilation that people might wake up and begin to become concerned about each other. And so also with the famines in Africa. Many similar scenes of joy and despair kept me in balance. I ended up the experience in a very peaceful space, feeling that though I had been through a lot, I had accomplished a great deal. I felt wonderful, free, and clear.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~100% | 50-200mg | 200-400mg | 400-800mg | 800mg+ |
| Dried | 10-20g | 20-30g | 30-40g | 40g+ |
| Fresh | 50-100g | 100-150g | - | 200g+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects | Total |
|---|---|---|---|---|---|---|
| Oral | 45-90 min | 1.0-2.0 hrs | 4.0-6.0 hrs | 2.0-3.0 hrs | 6.0-36.0 hrs | 8.0-12.0 hrs |
| Dried | 1.0-2.0 hrs | - | 4.0-8.0 hrs | - | 6.0-8.0 hrs | 6.0-12.0 hrs |
| Fresh | 1.0-2.0 hrs | - | 4.0-8.0 hrs | - | 6.0-8.0 hrs | 6.0-12.0 hrs |
Tolerance
Effects
- Stimulation
- Physical euphoria
- Creativity enhancement
- Mental/physical stimulation
- Spontaneous tactile sensations
- Nausea
- Pupil dilation
- Restlessness
- Sweating/chills
- Muscle tension
- Insomnia
- Increased heart rate
- Loss of appettite
- Body tremors
- Chest and neck pain
- Spontaneous bodily sensations
- Decreased appetite
- Suggestibility enhancement
- Change in consciousness
- Pupil dialation
- Analysis enhancement
- Cognitive euphoria
- Conceptual thinking
- Emotion enhancement
- Empathy enhancement
- Immersion enhancement
- Spirituality enhancement
- Unity and interconnectedness
- Euphoria
- Empathy
- Insight
- Novelty enhancement
- Personal meaning enhancement
- Wakefulness
- Feelings of insight
- Mood lift
- Giggling
- Increase in energy happy feelings
- Confusion
- Delusions
- Memory suppression
- Thought loops
- Time distortion
- Ego death
- Change in perception
- Ego softening
- Feelings of interdependent opposites
- Personal bias suppression
- Perspective alterations
- Thought acceleration
- Unusla thoughts and speech
- Mild to extreme distractability
- Changes in time and reality
- Changes in self control
- Tactile enhancement
- Color enhancement
- Pattern recognition enhancement
- Visual acuity enhancement
- Increased music appreciation
- Auditory enhancement
- Synaesthesia
- Brightened colour
- Enhanced tactile sensation
- Acuity enhancement
- Bodily control enhancement
- Colour enhancement
- Colour shifting
- Tracers
- Brightening of colors
- Drifting
- Internal hallucinations
- External hallucinations
- Closed/Open eye visuals
- After images
- Auditory distortion
- Auditory hallucinations
- Autonomous entities
- Scenery slicing
- Symmetrical texture repetition
- Closed and open eye visuals
Combinations
PiHKAL / TiHKAL
“I would have liked to, and was expecting to, have an exciting visual day, but I seemed to be unable to escape self-analysis. At the peak of the experience I was quite intoxicated and hyper with energy, so that it was not hard to move around. I was quite restless. But I spent most of the day in considerable agony, attempting to break through without success. I learned a great deal about myself and my inner workings. Everything almost was, but in the final analysis, wasn’t. I began to become aware of a point, a brilliant white light, that seemed to be where God was entering, and it was inconceivably wonderful to perceive it and to be close to it. One wished for it to approach with all one’s heart. I could see that people would sit and meditate for hours on end just in the hope that this little bit of light would contact them. I begged for it to continue and come closer but it did not. It faded away not to return in that particular guise the rest of the day. Listening to Mozart’s Requiem, there were magnificent heights of beauty and glory. The world was so far away from God, and nothing was more important than getting back in touch with Him. But I saw how we created the nuclear fiasco to threaten the existence of the planet, as if it would be only through the threat of complete annihilation that people might wake up and begin to become concerned about each other. And so also with the famines in Africa. Many similar scenes of joy and despair kept me in balance. I ended up the experience in a very peaceful space, feeling that though I had been through a lot, I had accomplished a great deal. I felt wonderful, free, and clear.”