I am a highly sensitive person - I've never done any cactus. Never any psychs. Never shrooms. But I'll be in Quito next month. And I have a connection to the land that very few ppl in my life know about. I found out about this experience super randomly.
Mescaline
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 27 combo interactions documented
- PubChem toxicity data
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 6 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 27 combo interactions documented
- PubChem toxicity data
Aliases: San, Mesc, Peyote, Cactus, Buttons, san-pedro
Summary
3,4,5-Trimethoxyphenethylamine (also known as mescaline) is a naturally-occurring classical psychedelic substance of the phenethylamine class. It occurs naturally in the peyote cactus (Lophophora williamsii), San Pedro cactus (Echinopsis pachanoi), Peruvian Torch cactus (Echinopsis peruviana) as well as the Cactaceae plant and the Fabaceae bean families. It is one of the oldest known hallucinogens and the parent compound of the psychedelic phenethylamines, one of the two major subclasses of psychedelic compounds (along with tryptamines).
Perspectives
“This is a magical substance—it is intricate and complex, with odd little surprises hiding in all of its secret places. Everything is exactly as it should be—the beautiful naivety of youth, manifest as resplendent color and energy.”
“I would have liked to, and was expecting to, have an exciting visual day, but I seemed to be unable to escape self-analysis. At the peak of the experience I was quite intoxicated and hyper with energy, so that it was not hard to move around. I was quite restless. But I spent most of the day in considerable agony, attempting to break through without success. I learned a great deal about myself and my inner workings. Everything almost was, but in the final analysis, wasn’t. I began to become aware of a point, a brilliant white light, that seemed to be where God was entering, and it was inconceivably wonderful to perceive it and to be close to it. One wished for it to approach with all one’s heart. I could see that people would sit and meditate for hours on end just in the hope that this little bit of light would contact them. I begged for it to continue and come closer but it did not. It faded away not to return in that particular guise the rest of the day. Listening to Mozart’s Requiem, there were magnificent heights of beauty and glory. The world was so far away from God, and nothing was more important than getting back in touch with Him. But I saw how we created the nuclear fiasco to threaten the existence of the planet, as if it would be only through the threat of complete annihilation that people might wake up and begin to become concerned about each other. And so also with the famines in Africa. Many similar scenes of joy and despair kept me in balance. I ended up the experience in a very peaceful space, feeling that though I had been through a lot, I had accomplished a great deal. I felt wonderful, free, and clear.”
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA ~100% | 50-200mg | 200-400mg | 400-800mg | 800mg+ |
| Dried | 10-20g | 20-30g | 30-40g | 40g+ |
| Fresh | 50-100g | 100-150g | - | 200g+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 45-90 min | 1-2 hrs | 4-6 hrs | 2-3 hrs | 8-12 hrs |
| Dried | 1-2 hrs | - | 4-8 hrs | 2-3 hrs | 6-12 hrs |
| Fresh | 1-2 hrs | - | 4-8 hrs | 2-3 hrs | 6-12 hrs |
Effect Profile
597 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 520 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
8.8
Intense+
9/10
Strong visuals, headspace, auditory effects, and body load
Visual Intensity
×3
10
external hallucinations
internal hallucinations
color enhancement
autonomous entities
drifting
synaesthesia
+9 more
Headspace Depth
×3
10
conceptual thinking
personal meaning enhancement
feelings of interdependent opposites
emotion enhancement
perspective alterations
delusions
+4 more
Auditory Effects
×1
10
auditory enhancement
auditory distortion
auditory hallucinations
synaesthesia
Body Load / Somatic Effects
×1
10
nausea
muscle tension
increased heart rate
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1d
Half tolerance
7d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Classic psychedelic cross-tolerance pattern inferred from user reports and HR references; magnitude varies. Data quality: mixed formal/anecdotal.
Cross-Tolerances
Effects
Aggregated from 520 Erowid and 77 Bluelight experience reports
Positive Effects 83
Visual Distortions
65.1%
79%
Color Enhancement
50.3%
88%
Euphoria
42.2%
89%
Stimulation
42.0%
82%
Awe
42.0%
83%
Music Enhancement
41.9%
87%
Tactile Enhancement
41.4%
79%
Empathy
39.6%
84%
Closed-Eye Visuals
29.2%
88%
Introspection
28.1%
84%
Joy
28.0%
86%
Surface Breathing
26.0%
84%
Auditory Effects
25.6%
81%
Focus Enhancement
25.6%
82%
Oneness
22.0%
86%
Visual Trails
22.0%
87%
Peace
22.0%
85%
Insight
20.0%
84%
Morphing
20.0%
87%
Body High
19.6%
86%
Adverse Effects 40
Nausea
58.1%
85%
Anxiety
43.9%
75%
Confusion
28.0%
77%
Sedation
25.2%
78%
Vomiting
24.0%
85%
Restlessness
12.0%
81%
Muscle Tension
11.0%
75%
Memory Suppression
8.3%
70%
Fear
8.0%
85%
Dizziness
8.0%
80%
Thought Disorganization
8.0%
85%
Stomach Cramps
8.0%
81%
Headache
6.3%
90%
Insomnia
6.0%
80%
Sadness
6.0%
81%
Focus Suppression
6.0%
75%
Increased Heart Rate
5.2%
70%
Jaw Clenching
4.5%
85%
Thought Loops
4.2%
81%
Irritability
4.0%
70%
Combinations
Cross-Check Mescaline with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Reddit 8 reports 1 positive 5 neutral 2 cautionary visit
Before we get into comparing cacti I just want to outline who Home Depot and Lowes gets their cacti from and why the characteristics I'm going to unpack are so easy to look for in a side by side retail setting with only one growing source.
This is my first time consuming San Pedro on its own. I used a diluted vinegar solution for each boil and I boiled for 1 hour, topped off the water and boiled again for an hour, decanted/strained and repeated 2 more times.
There was a portion of my last trip where I felt bored or underwhelmed I guess? I had this really strong feeling of "been there, done that." It also felt like I was the elder generation watching the youth generation go through the motions of growing up.
Hey Reddit! Looking to try mescaline for the first time tomorrow as a very experienced heavy-dose psychonaut. Considering taking 300-400mg for the first time, potentially mixing in 2C-B and LSD.
Yesterday I took a healthy dose of tbmc. I had read about two golf balls worth is a good dose. I blended it with water and choked it down (so gross). I had some weird vision changes 90 minutes in and felt a bit incapacitated.
My first time taking San Pedro in Peru. I went with my friend and we did it with two shaman. It started inside, where they blessed us and asked us our intentions. then after we drank the juice, we went outside and sat in the grass.
Wondering if somebody would be willing to help me. I was on a medication called mirtazapine for several years. For PTSD, depression, anxiety. I couldn't get off of it without getting sick. Finally it caused me so many side effects I had to get off of it and it took me a year.
Erowid 8 reports 3 positive 3 neutral 2 cautionary visit
I wasnt a spiritual person, I was skeptical if anything, but a foot of cactus changed everything. I should first mention that I and everyone involved are moderate pot smokers, and that we had never tried any other hallucinogen apart from the person who suggested the idea.
I am a male (vintage hippy) who has had a fair share of psychadelic experiences in my time. None, however could equal up to the life-changing trip I experienced after ingesting 'the divine catus'. It was saturday in El Paso,Texas.
Background: I'm a computer programmer with one kid, and a wife who doesn't nag, so I can go out and have all kinds of fun by myself. Recently I've felt relatively good about myself, but I've also feĺt like I can't feel love for people the way I should, and sometimes the more awesome someone is, the more I resent him/he...
Like many who take mescaline I cannot quite comprehend how to explain such a wonder to those who have and haven't tried, but it's like being home; wherever you are, knowing the truth lies in now, not tommorow, not yesterday, and not your hairbrush.
It could be worse. We could be stars: responsible for entire solar systems. 97 degrees Fahrenheit and not a butt in the sky at Enchanted Rock a jaunt outside of Llano, Texas.
Mescaline was never a drug I had considered trying before. It had never been on my radar, had never been easily accessible. My friend J, who Ive had several psychedelic adventures with, loves mescaline, and happened to come across some and offered me the opportunity to try it with him.
Dipped My Toes in the Warm Waters of Mescaline I have had great difficulty finding Mescaline dosage information and trip reports online and so I feel it is my duty to publish my experiences.
This is an experience with mescaline on the beach in Port Aransas/Corpus Christi, Texas. Me and my ex-girlfriend K got two capsules of mescaline from her brother and decided to go down to the coast and camp out.
Bluelight 7 threads 1 positive 5 neutral 1 cautionary visit
Let me preface this report by laying down the groundwork upon which the trip was built. It was Sunday. On Friday night I had taken two hits of potent LSD on my own, at night, in my apartment.
I haven't posted on Bluelight in aeons, but I felt inspired to share a recent experience I had with Peyote in conjunction with the Lakota Native American Church. I used to use many substances recreationaly, however after an intense experience with psychedelic medicines and plant medicines I underwent an extreme spiritu...
I wrote this in response to a thread in psychedelic discussion, had no intention to go into so much detail and unexpectedly ended up with a bit of a report. Introduction These three experiences all happened within the space of 6 months when I was 19.
Like many who take mescaline I cannot comprehend how to explain such a wonder to those who have and haven't tried, but it's like being home; wherever you are, knowing the truth lies in now, not tommorow, not yesterday.
Mescaline (San Pedro) - Semi-experienced - Universe Shattering Huxlian Mindfuck 9:24 pm: I've reduced the mescaline to a (slightly more than) reasonable amount. Just brewed a pot of ginger tea, sweetened slightly by some honey.
Hi, This is a very old experience I'd like to talk about. By the way, I am currently in Australia but not a native speaker, so I am sorry if I make any mistake. I tried San Pedro three times. The first time, I used the classic method, so boiled it down and drunk it.
I just wanted to throw this piece of information out there so maybe people can benefit from it with future use. It's my theory now, that combining psychedelics with zofran (selective serotonin antagonist) vastly increases their potency.
Bluelight Reference Guide
Phenethylamines The Big & Dandy Mescaline and Mesc. Cactus Thread - 3rd Button
Welcome to the Big & Dandy Mescaline/Cactus Thread Mescaline --------- Peyote Cactus Mescaline Trip Reports on Bluelight External links: Wikipedia: Mescaline Page Peyote Page San Pedro Page Peruvian Torch Page Erowid: Mescaline Vault Cacti Vault Peyote Vault San Pedro Potency FAQ San Pedro / Cacti Dosage PIHKAL Mescali...
Read full thread on Bluelight →PiHKAL / TiHKAL
PiHKAL #96: M
“I would have liked to, and was expecting to, have an exciting visual day, but I seemed to be unable to escape self-analysis. At the peak of the experience I was quite intoxicated and hyper with energy, so that it was not hard to move around. I was quite restless. But I spent most of the day in considerable agony, attempting to break through without success. I learned a great deal about myself and my inner workings. Everything almost was, but in the final analysis, wasn’t. I began to become aware of a point, a brilliant white light, that seemed to be where God was entering, and it was inconceivably wonderful to perceive it and to be close to it. One wished for it to approach with all one’s heart. I could see that people would sit and meditate for hours on end just in the hope that this little bit of light would contact them. I begged for it to continue and come closer but it did not. It faded away not to return in that particular guise the rest of the day. Listening to Mozart’s Requiem, there were magnificent heights of beauty and glory. The world was so far away from God, and nothing was more important than getting back in touch with Him. But I saw how we created the nuclear fiasco to threaten the existence of the planet, as if it would be only through the threat of complete annihilation that people might wake up and begin to become concerned about each other. And so also with the famines in Africa. Many similar scenes of joy and despair kept me in balance. I ended up the experience in a very peaceful space, feeling that though I had been through a lot, I had accomplished a great deal. I felt wonderful, free, and clear.”
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