After trying 11 other antidepressants and countless other classes of psychiatric drugs (been on psych meds the past 14 years), an enlightened doctor finally prescribed me a MAOI. I take trancylpromine (Parnate), currently 20 mg in the morning (around 6 am) and 10 mg around noon.
Tranylcypromine
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 2 corroborating sources
- 1 ROA with full dose ladder
- duration data present
- 18 combo interactions documented
- PubChem toxicity data
- dose data not in PW/TripSit (unverifiable)
Aliases: Tcp, 2-pcpa, Parnate, Skf-385
Summary
Tranylcypromine is a non-selective, irreversible MAOI typically reserved for treatment-resistant major depressive disorder. Requires strict dietary restrictions to avoid tyramine-rich foods, which can cause life-threatening hypertensive crisis. Allow adequate washout periods when switching from other antidepressants (typically 2 weeks, but 5 weeks for fluoxetine).
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 10-20mg | 30-40mg | 50-60mg | 60mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
Effect Profile
2 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Stimulant
4.9
Moderate+
5/10
Moderate stimulation, euphoria, and anxiety/jitters
Stimulation / Energy
×3
7
stimulation
increased energy
alertness enhancement
Euphoria / Mood Lift
×2
7
cognitive euphoria
mood lift
mood elevation
Focus / Productivity
×2
0
Anxiety / Jitters
×1
6
anxiety
restlessness
Based on reports from:
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Tolerance Decay
Half tolerance
3d
Baseline
~21d
Classical recreational-style tolerance modeling is not applicable. Clinical “tolerance” to antidepressant effect may not develop; however, receptor adaptations and withdrawal phenomena can occur with abrupt cessation. Cross‑tolerance applies pharmacodynamically to other irreversible MAOIs (phenelzine, isocarboxazid).
Effects
Positive
- Stimulation
- Increased energy
- Anxiolysis
Negative
- Insomnia
- Restlessness
- Headache
- Dry mouth
- Insomnia or sleep disturbances
- Orthostatic hypotension
- Sedation
Positive
- Mood lift
- Alertness enhancement
- Mood elevation
- Improved motivation
- Enhanced sociability
- Cognitive Euphoria
Negative
- Anxiety
- Agitation
- Dizziness
- Talkativeness
Positive
- Increased music appreciation
- Perception of bodily lightness
- Tactile enhancement
Negative
- Light sensitivity
- Decreased Libido
- Appetite Suppression
- Disinhibition
- Dulled perception
- Sexual Dysfunction
- Spontaneous physical sensations
Combinations
Cross-Check Tranylcypromine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 1 report 1 neutral visit
Pill Identifiers
1
known pill identifiers on record — view imprints, colors, shapes, and images
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Tranylcypromine's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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