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    ⚠ This substance involves MAOI activity. Dangerous interactions can occur with many common foods and medications. Research contraindications thoroughly.

    Tranylcypromine

    Aliases: Tcp, 2-pcpa, Parnate, Skf-385

    Stimulant

    Summary TheDrug.Wiki

    Tranylcypromine is a non-selective, irreversible MAOI typically reserved for treatment-resistant major depressive disorder. Requires strict dietary restrictions to avoid tyramine-rich foods, which can cause life-threatening hypertensive crisis. Allow adequate washout periods when switching from other antidepressants (typically 2 weeks, but 5 weeks for fluoxetine).

    Dose Information TheDrug.Wiki

    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki

    ROA Onset Comeup Peak Offset After Effects
    Oral 1-2 hrs 1-2 hrs 2-4 hrs 12-24 hrs 72-120 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.9
    Moderate+ 5/10

    Moderate stimulation, euphoria, and anxiety/jitters

    Stimulation / Energy ×3
    7
    stimulation increased energy alertness enhancement
    Euphoria / Mood Lift ×2
    7
    cognitive euphoria mood lift mood elevation
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    6
    anxiety restlessness
    Based on reports from:
    Erowid Experience Reports PsychonautWiki Tranylcypromine
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Effects TheDrug.Wiki

    Positive
    • Stimulation
    • Increased energy
    • Anxiolysis
    Negative
    • Insomnia
    • Restlessness
    • Headache
    • Dry mouth
    • Insomnia or sleep disturbances
    Neutral
    • Orthostatic hypotension
    • Sedation
    Positive
    • Mood lift
    • Alertness enhancement
    • Mood elevation
    • Improved motivation
    • Enhanced sociability
    • Cognitive Euphoria
    Negative
    • Anxiety
    • Agitation
    • Dizziness
    Neutral
    • Talkativeness
    Positive
    • Increased music appreciation
    • Perception of bodily lightness
    • Tactile enhancement
    Negative
    • Light sensitivity
    • Decreased Libido
    • Appetite Suppression
    • Disinhibition
    Neutral
    • Dulled perception
    • Sexual Dysfunction
    • Spontaneous physical sensations

    Combinations TripSit

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
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    Tranylcypromine's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki