Home
    Disclaimer
    ⚠ This substance involves MAOI activity. Dangerous interactions can occur with many common foods and medications. Research contraindications thoroughly.

    Tranylcypromine Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 3 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 18 combo interactions documented
    • PubChem toxicity data
    • dose data not in PW/TripSit (unverifiable)

    Aliases: Tcp, 2-pcpa, Parnate, Skf-385

    Stimulant

    Summary dose.wiki

    Tranylcypromine is a non-selective, irreversible MAOI typically reserved for treatment-resistant major depressive disorder. Requires strict dietary restrictions to avoid tyramine-rich foods, which can cause life-threatening hypertensive crisis. Allow adequate washout periods when switching from other antidepressants (typically 2 weeks, but 5 weeks for fluoxetine).

    Dose Information dose.wiki Drugs.Wiki

    No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.

    Dose basis. Prescription therapeutic dosing from clinical references; not for recreational use. Start low and titrate under medical supervision only. Data primarily from StatPearls/label summaries and DrugBank. (Dose figures and this note are from Drugs.Wiki.)

    ROA Light Common Strong Heavy
    Oral 10-20mg 30-40mg 50-60mg 60mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects dose.wiki Drugs.Wiki

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 1-2 hrs 1-2 hrs 2-4 hrs 12-24 hrs 72-120 hrs 16-32 hrs

    Effect Profile

    2 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 4.9
    Moderate+ 5/10

    Moderate stimulation, euphoria, and anxiety/jitters

    Stimulation / Energy ×3
    7
    stimulation increased energy alertness enhancement
    Euphoria / Mood Lift ×2
    7
    cognitive euphoria mood lift mood elevation
    Focus / Productivity ×2
    0
    ⚠ Anxiety / Jitters ×1
    6
    anxiety restlessness
    Based on reports from:
    Erowid Experience Reports
    View methodology →

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Tranylcypromine there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Tranylcypromine (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Tranylcypromine
    Unit
    mg
    Description 
    Tranylcypromine
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 10 · light 10-20 · common 30-40 · strong 50-60 · heavy 60+

Oral duration: onset 1-2h · come-up 1-2h · peak 2-4h · offset 12-24h · total 16-32h · after-effects 72-120h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 35 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Half tolerance 3d Baseline ~21d

    Classical recreational-style tolerance modeling is not applicable. Clinical “tolerance” to antidepressant effect may not develop; however, receptor adaptations and withdrawal phenomena can occur with abrupt cessation. Cross‑tolerance applies pharmacodynamically to other irreversible MAOIs (phenelzine, isocarboxazid).

    Effects dose.wiki

    Positive
    • Stimulation
    • Increased energy
    • Anxiolysis
    Negative
    • Insomnia
    • Restlessness
    • Headache
    • Dry mouth
    • Insomnia or sleep disturbances
    Neutral
    • Orthostatic hypotension
    • Sedation
    Positive
    • Mood lift
    • Alertness enhancement
    • Mood elevation
    • Improved motivation
    • Enhanced sociability
    • Cognitive Euphoria
    Negative
    • Anxiety
    • Agitation
    • Dizziness
    Neutral
    • Talkativeness
    Positive
    • Increased music appreciation
    • Perception of bodily lightness
    • Tactile enhancement
    Negative
    • Light sensitivity
    • Decreased Libido
    • Appetite Suppression
    • Disinhibition
    Neutral
    • Dulled perception
    • Sexual Dysfunction
    • Spontaneous physical sensations

    Combinations

    Cross-Check Tranylcypromine with another substance

    Community Trip Reports

    Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.

    Erowid 1 report 1 neutral visit
    Psychiatric Use neutral exp #106885

    After trying 11 other antidepressants and countless other classes of psychiatric drugs (been on psych meds the past 14 years), an enlightened doctor finally prescribed me a MAOI. I take trancylpromine (Parnate), currently 20 mg in the morning (around 6 am) and 10 mg around noon.

    mouse · 30 - 50 mg oral / 900 mg oral / 50 ug oral / 0.5 mg oral

    Pill Identifiers

    1 known pill identifiers on record — view imprints, colors, shapes, and images
    →
    Tranylcypromine's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    💊 Pill Identifier 📘 Experience Reports 📖 dose.wiki 📖 PsychonautWiki