I have done yopo several times and just remembered about it today as a close friend tried it last night and I decided to have a quick read of some of the experience files. One thing I have noticed is a lot of people are snorting the outer shell of the seed.
Yopo
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki)
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- toxicity data (PsychonautWiki)
Aliases: "anadenanthera, anadenanthera
Summary
Anadenanthera peregrina, also known as yopo, is a perennial tree native to the Caribbean and South America. It is an entheogen containing 5-MeO-DMT and DMT, and is used in healing ceremonies and rituals. It is also a source of dietary calcium.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 3-5seeds | 5-7seeds | 7-10seeds | 10seeds+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Insufflated | 0-1 min | 3-5 min | 5-15 min |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.5
Moderate
4/10
Strong body load with moderate visuals, low headspace
Visual Intensity
×3
6
color enhancement
tracers
pattern recognition enhancement
visual distortions
Headspace Depth
×3
3
introspection
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
9
nausea
vasoconstriction
teeth grinding
increased heart rate
sweating
Empathogen
4.6
Moderate+
5/10
Moderate stimulation, sensory enhancement, and euphoria with low empathy
Empathy / Social Openness
×3
2
increased sociability
Euphoria / Mood Elevation
×2
6
euphoria
cognitive euphoria
Stimulation
×1
7
stimulation
wakefulness
teeth grinding
increased heart rate
Sensory Enhancement
×1
7
tactile enhancement
color enhancement
increased libido
Based on reports from:
Add to PsychonautWiki Journal
The PsychonautWiki Journal logging app doesn't include every substance. To track Yopo there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:
⬇ Download import file
Import this file as custom substances
and you get "Yopo (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Name
Yopo
Unit
seeds
Description
Yopo Source: SubstanceSearch (substancesearch.com) Insufflated dose (seeds): threshold 3 · light 3-5 · common 5-7 · strong 7-10 · heavy 10+ Insufflated duration: onset 0-1m · peak 3-5m · total 5-15m · after-effects 1-3h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 6 seeds (Insufflated).
The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
Negative
- Increased heart rate
- Pupil dilation
- Teeth grinding
- Nausea
- Vasoconstriction
- Increased perspiration
- Sweating
- Dilated pupils
- Decreased appetite
Positive
- Introspection
- Euphoria
- Wakefulness
- Cognitive euphoria
- Analysis enhancement
- Increased sociability
- Motivation enhancement
Negative
- Anxiety
- Thought acceleration
- Time distortion
Positive
- Color enhancement
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
- Pattern recognition enhancement
Negative
- Dehydration
- Appetite suppression
- Light sensitivity
- Visual distortions
Combinations
Cross-Check Yopo with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 2 reports 2 neutral visit
The round flat seeds I purchased a week ago arrive today. Very excited to attempt this, I have done DMT in the past but never Yopo. I am using baking powder in todays attempt. My mindset going in is anxious about the pain but also anxious about my journey.
Bluelight 5 threads 5 neutral visit
Note: Just to clarify - The 'Yopo' seeds i used were of the Anadenanthera Colubrina variety, not the Anadenanthera Peregrina variety as 'Yopo' is traditionally known. They contain DMT and 5Meo-DMT, and can be potentiated using MAOI's such as syrian rue, which i used in this case, thus- Yopohuasca.
Cohoba Snuff ; Anadenanthera colubrina (Dose: 3 seeds) – 2nd Experience-" In The Hallways of Souls" Setting: My room (a pleasantly calm and colorful environment) at 11:05 PM, Feb.
Herein you will find the commentary and summary of my two experiences with yopo. I have taken yopo or cohoba twice, both times the night of this report being written, I aqquired quie a few herbs and resins and seeds today, from my reliable favourite source, among them were the few I experienced tonight.
For reference, here's my report on snorting yopo: http://www.bluelight.org/vb/threads/819252-(Yopo-3-seeds)-First-time-heaven-and-hell In this report, I'm going to try and compare and contrast the effects of the 2 methods, as there is no real info on the net that compares the 2 methods, which is very irritating.
To begin, I suppose it would probably be a good idea to provide as best a guide for preparing these seeds as possible, and as I did it. I do not know if my preparation was just very good or these were strong seeds or both. To begin, I toasted 3 seeds in the microwave for approx 40 seconds.
Yopo's nerd page
Pharmacology, chemical data, effect profiles, and more
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Helpful Links
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