I have done yopo several times and just remembered about it today as a close friend tried it last night and I decided to have a quick read of some of the experience files. One thing I have noticed is a lot of people are snorting the outer shell of the seed.
Yopo
Encyclopedic
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Encyclopedic
Typical encyclopedia coverage. Cross-reference for important decisions.
- 1 source
- 1 ROA with full dose ladder
- duration data present
- 19 combo interactions documented
- PubChem toxicity data
Aliases: "anadenanthera, anadenanthera
Summary
Anadenanthera peregrina, also known as yopo, is a perennial tree native to the Caribbean and South America. It is an entheogen containing 5-MeO-DMT and DMT, and is used in healing ceremonies and rituals. It is also a source of dietary calcium.
Dose Information
No curated dose ladder is available for this substance. The figures below are drawn from SubstanceIndex (DoseWiki) as a fallback — often a conservative threshold only. Treat them as approximate and cross-reference before use.
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 3-5seeds | 5-7seeds | 7-10seeds | 10seeds+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Peak | Total |
|---|---|---|---|
| Insufflated | 0-1 min | 3-5 min | 5-15 min |
Effect Profile
3 reportsScores (1–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Weighted by importance: core (×3), major (×2), minor (×1)
Psychedelic
3.5
Moderate
4/10
Strong body load with moderate visuals, low headspace
Visual Intensity
×3
6
color enhancement
tracers
pattern recognition enhancement
visual distortions
Headspace Depth
×3
3
introspection
time distortion
Auditory Effects
×1
0
Body Load / Somatic Effects
×1
9
nausea
vasoconstriction
teeth grinding
increased heart rate
sweating
Empathogen
4.6
Moderate+
5/10
Moderate stimulation, sensory enhancement, and euphoria with low empathy
Empathy / Social Openness
×3
2
increased sociability
Euphoria / Mood Elevation
×2
6
euphoria
cognitive euphoria
Stimulation
×1
7
stimulation
wakefulness
teeth grinding
increased heart rate
Sensory Enhancement
×1
7
tactile enhancement
color enhancement
increased libido
Based on reports from:
Tolerance
Build-up
develops rapidly after a single use
Reset
7–14 days for baseline
Tolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Acute tolerance: develops within a single session — the reset numbers above apply after sustained heavy use, not after one binge. Within-session tachyphylaxis usually resets largely overnight.
Effects
Positive
- Stimulation
Negative
- Increased heart rate
- Pupil dilation
- Teeth grinding
- Nausea
- Vasoconstriction
- Increased perspiration
- Sweating
- Dilated pupils
- Decreased appetite
Positive
- Introspection
- Euphoria
- Wakefulness
- Cognitive euphoria
- Analysis enhancement
- Increased sociability
- Motivation enhancement
Negative
- Anxiety
- Thought acceleration
- Time distortion
Positive
- Color enhancement
- Increased music appreciation
- Tactile enhancement
- Increased libido
- Tracers
- Pattern recognition enhancement
Negative
- Dehydration
- Appetite suppression
- Light sensitivity
- Visual distortions
Combinations
Cross-Check Yopo with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, and Bluelight. Click a source to expand. Reports are harm-reduction context, not medical guidance.
Erowid 2 reports 1 neutral 1 cautionary visit
The round flat seeds I purchased a week ago arrive today. Very excited to attempt this, I have done DMT in the past but never Yopo. I am using baking powder in todays attempt. My mindset going in is anxious about the pain but also anxious about my journey.
Bluelight 5 threads 4 neutral 1 cautionary visit
Note: Just to clarify - The 'Yopo' seeds i used were of the Anadenanthera Colubrina variety, not the Anadenanthera Peregrina variety as 'Yopo' is traditionally known. They contain DMT and 5Meo-DMT, and can be potentiated using MAOI's such as syrian rue, which i used in this case, thus- Yopohuasca.
Cohoba Snuff ; Anadenanthera colubrina (Dose: 3 seeds) – 2nd Experience-" In The Hallways of Souls" Setting: My room (a pleasantly calm and colorful environment) at 11:05 PM, Feb.
Herein you will find the commentary and summary of my two experiences with yopo. I have taken yopo or cohoba twice, both times the night of this report being written, I aqquired quie a few herbs and resins and seeds today, from my reliable favourite source, among them were the few I experienced tonight.
For reference, here's my report on snorting yopo: http://www.bluelight.org/vb/threads/819252-(Yopo-3-seeds)-First-time-heaven-and-hell In this report, I'm going to try and compare and contrast the effects of the 2 methods, as there is no real info on the net that compares the 2 methods, which is very irritating.
To begin, I suppose it would probably be a good idea to provide as best a guide for preparing these seeds as possible, and as I did it. I do not know if my preparation was just very good or these were strong seeds or both. To begin, I toasted 3 seeds in the microwave for approx 40 seconds.
Yopo's nerd page
Pharmacology, chemical data, effect profiles, and more
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