Psychoactive Class
Psychedelic
Receptor Profile
Receptor Actions
Agonists
5-HT2A receptor agonist (partial)
5-HT1A receptor agonist
Inhibitors
Serotonin reuptake inhibitor (weak)
Norepinephrine reuptake inhibitor (weak)
Dopamine reuptake inhibitor (weak)
Effect Profile
Curated + 3 Reports
Psychedelic
3.5
Strong body load with moderate visuals, low headspace
Visual Intensity×3
6
Headspace Depth×3
3
Auditory Effects×1
0
Body Load / Somatic Effects×1
9
Empathogen
4.6
Moderate stimulation, sensory enhancement, and euphoria with low empathy
Empathy / Social Openness×3
2
Euphoria / Mood Elevation×2
6
Stimulation×1
7
Sensory Enhancement×1
7
Based on reports from:
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Full tolerance
1h
Half tolerance
10d
Baseline
~14d
Experience Report Analysis
Erowid
3
Reports
2003–2021
Date Range
1
With Age Data
Demographics
Gender Distribution
Age Distribution
Reports Over Time
References
Data Sources
Cited References
- Drug Users Bible: Yopo
- Erowid: Anadenanthera
- Fuller et al. 1995: Tissue distribution and metabolism of bufotenine
- Health Canada Drug Status Report: Anadenanthera peregrina
- Ott 2001: Pharmañopo-Psychonautics of Bufotenine
- PsychonautWiki: Anadenanthera peregrina
- PsychonautWiki: Bufotenin
- Rodd 2002: Snuff synergy with yopo and Banisteriopsis caapi
- Torres & Repke 2006: Anadenanthera - Visionary Plant of Ancient South America
- Tripsitter: Yopo
- Tripsitter Substack: Yopo