Summary
Oral bioavailability doubles when taken with food; dosing on an empty stomach delivers only ~36% of the intended exposure, leading users to redose unnecessarily. Therapeutic QTc prolongation averages 10-20 msec, but heavy recreational doses (>160 mg/day) or IV diversion markedly increases torsade risk. IM ziprasidone reaches Cmax within 60 minutes and has a 2-5 hour half-life, making it a common ER 'trip-stopper'. Forum reports describe 60-120 mg oral as a reliable 'stimulant-comedown knockout', with sleep onset 2-4 hours after dosing. Extrapyramidal reactions (akathisia, dystonia) and very rare tardive dystonia have occurred after weeks on 80-120 mg/day regimens.
Dose Information
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 1-3 hrs | 1-2 hrs | 3-6 hrs | 2-4 hrs | 6-24 hrs |
| Intramuscular | 15-30 min | 30-60 min | 30-90 min | 2-4 hrs | 6-24 hrs |
Tolerance
Build-up
develops over 1–4 weeks of regular use
Reset
days to weeks depending on duration of use
Effects
Positive
- Stimulation
- Physical Euphoria
- Pain Relief
Negative
- Akathisia
- Restlessness
- Motor impairment
- Sweating
- Sedation
- Somnolence
- Itchiness
Positive
- Anxiety suppression
- Reduced anxiety
- Euphoria
Negative
- Emotion suppression
- Motivation suppression
- Motor control loss
- Cognitive fatigue
- Dizziness
- Thought deceleration
- Constipation
Positive
Negative
- Light sensitivity
- Disinhibition
- Appetite Suppression
- Decreased Libido
- Orgasm Suppression
- Acuity Suppression
- Appetite suppression
- Dulled perception
- Increased sexuality
- Visual and auditory hallucinations