Summary
2-MA was investigated as an anorectic in the 1950s and is approximately one-tenth as potent as dextroamphetamine by weight. Modern knowledge comes almost entirely from research-chemical circles. Users report a functional, relatively clean stimulation with muted euphoria compared to amphetamine, though higher doses can induce anxiety, vasoconstriction, and tremor. Being an ortho-methyl analogue, it appears to have minimal serotonergic activity. Conservative dosing (spaced at least 4-6 hours), active cooling, and hydration are strongly advised.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Insufflated | 10-30mg | 30-50mg | 50-70mg | 70mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 15-30 min | 30-60 min | 1-2.5 hrs | 2-4 hrs | 1-10 hrs |
| Insufflated | 5-15 min | 15-30 min | 1-2.5 hrs | 2-4 hrs | 1-10 hrs |
| Rectal | 3-10 min | 10-20 min | 1-2.5 hrs | 2-4 hrs | 1-10 hrs |
Tolerance
Build-up
develops over days to weeks of regular use
Reset
3–7 days for acute; 1–3 weeks for full reset
Effects
Positive
- Stimulation
- Increased energy/alertness
Negative
- Teeth grinding
- Increased perspiration
- Increased heart rate
- Vasoconstriction
- Weight loss
- Sweating
- Bruxism
- Decreased need for sleep
- Decreased appetite
- Disturbed sleep patterns
- Itchiness
Positive
- Focus enhancement
- Motivation enhancement
- Euphoria
- Increased sociability
- Wakefulness
- Cognitive euphoria
- Mood lift
Negative
- Anxiety
- Aggressiveness
- Excessive talking
- Moodiness
Positive
- Increased libido
- Color enhancement
- Increased music appreciation
- Brightened colour
Negative
- Appetite suppression
- Light sensitivity
- Increased sexuality
- Visual and auditory hallucinations
- Dulled perception
- Closed/Open eye visuals