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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    2-MA

    Aliases: Ortetamine, 2-methylamphetamine

    Stimulant Research-chemical

    Summary TheDrug.Wiki TripSit

    2-MA was investigated as an anorectic in the 1950s and is approximately one-tenth as potent as dextroamphetamine by weight. Modern knowledge comes almost entirely from research-chemical circles. Users report a functional, relatively clean stimulation with muted euphoria compared to amphetamine, though higher doses can induce anxiety, vasoconstriction, and tremor.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Insufflated 10-30mg 30-50mg 50-70mg 70mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 15-30 min 30-60 min 1-2.5 hrs 2-4 hrs 1-10 hrs
    Insufflated 5-15 min 15-30 min 1-2.5 hrs 2-4 hrs 1-10 hrs
    Rectal 3-10 min 10-20 min 1-2.5 hrs 2-4 hrs 1-10 hrs

    Effect Profile

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Stimulant 5.4
    Moderate+ 5/10

    Strong anxiety/jitters and euphoria with mild stimulation and focus

    Stimulation / Energy ×3
    5
    stimulation wakefulness
    Euphoria / Mood Lift ×2
    9
    euphoria cognitive euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    5
    focus enhancement motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding increased heart rate bruxism vasoconstriction sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 2-MA
    View methodology →

    Tolerance

    Build-up develops over days to weeks of regular use
    Reset 3–7 days for acute; 1–3 weeks for full reset

    Tolerance Decay

    Full tolerance 3d Half tolerance 7d Baseline ~30d

    Tolerance to stimulant effects tends to build quickly with consecutive-day use and decays over 1–6 weeks with abstinence; estimates are based on stimulant-class patterns and user reports (anecdotal). Avoid back-to-back days to keep tolerance lower and reduce compulsive redosing risk.

    Cross-Tolerances

    amphetamine
    70%
    methamphetamine
    60%
    cathinones
    50%
    other dopaminergic stimulants
    40%

    Effects TheDrug.Wiki TripSit

    Positive
    • Stimulation
    • Increased energy/alertness
    Negative
    • Teeth grinding
    • Increased perspiration
    • Increased heart rate
    • Vasoconstriction
    • Weight loss
    • Sweating
    • Bruxism
    Neutral
    • Decreased need for sleep
    • Decreased appetite
    • Disturbed sleep patterns
    • Itchiness
    Positive
    • Focus enhancement
    • Motivation enhancement
    • Euphoria
    • Increased sociability
    • Wakefulness
    • Cognitive euphoria
    • Mood lift
    Negative
    • Anxiety
    • Aggressiveness
    Neutral
    • Excessive talking
    • Moodiness
    Positive
    • Increased libido
    • Color enhancement
    • Increased music appreciation
    • Brightened colour
    Negative
    • Appetite suppression
    • Light sensitivity
    Neutral
    • Increased sexuality
    • Visual and auditory hallucinations
    • Dulled perception
    • Closed/Open eye visuals

    Combinations TripSit

    2-MA's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki