Summary
4-MEC is generally considered less potent than mephedrone, requiring approximately double the dose for comparable effects. It has a reputation for producing less intense euphoria but being more forgiving on the body. Intravenous use is particularly rough on veins and can cause vascular damage with chronic use. The substance has been sold in NRG-2 mixtures, often combined with other cathinones. Compulsive redosing is common, especially with insufflated use.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 50-100mg | 100-200mg | 200mg | 200mg+ |
| Insufflated | 25-40mg | 40-100mg | 100-150mg | 150mg+ |
Light
Common
Strong
Heavy
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | After Effects |
|---|---|---|---|---|---|
| Oral | 20-60 min | 30-45 min | 1-2 hrs | 1-3 hrs | 2-6 hrs |
| Insufflated | 5-10 min | 10-20 min | 1-2 hrs | 1-3 hrs | 2-6 hrs |
| Intravenous | - | 1-2 min | 20-30 min | 1-2 hrs | 2-6 hrs |
Tolerance
Build-up
develops rapidly, often within a single session; compulsive redosing common
Reset
a few days for acute tolerance
Effects
Positive
- Stimulation
- Increased energy/alertness
Negative
- Teeth grinding
- Weight loss
- Sweating
- Bruxism
- Decreased need for sleep
- Decreased appetite
- Disturbed sleep patterns
- Itchiness
Positive
- Euphoria
- Empathy enhancement
- Increased sociability
- Motivation enhancement
- Mood lift
Negative
- Anxiety
- Aggressiveness
- Time distortion
- Excessive talking
- Moodiness
Positive
- Tactile enhancement
- Music enhancement
- Increased music appreciation
- Increased libido
Negative
- Appetite suppression
- Dehydration
- Light sensitivity
- Disinhibition
- Increased sexuality
- Visual and auditory hallucinations