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    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    4-MEC

    Aliases: Nrg-2, 4-methylethcathinone, 4mec

    Stimulant Research-chemical

    Summary TheDrug.Wiki Erowid TripSit

    4-MEC is generally considered less potent than mephedrone, requiring approximately double the dose for comparable effects. It has a reputation for producing less intense euphoria but being more forgiving on the body. Intravenous use is particularly rough on veins and can cause vascular damage with chronic use.

    Dose Information TheDrug.Wiki TripSit

    ROA Light Common Strong Heavy
    Oral 50-100mg 100-200mg 200mg 200mg+
    Insufflated 25-40mg 40-100mg 100-150mg 150mg+
    Light Common Strong Heavy

    Onset, Duration & After-effects TheDrug.Wiki TripSit

    ROA Onset Comeup Peak Offset After Effects
    Oral 20-60 min 30-45 min 1-2 hrs 1-3 hrs 2-6 hrs
    Insufflated 5-10 min 10-20 min 1-2 hrs 1-3 hrs 2-6 hrs

    Effect Profile

    22 reports

    Scores (1–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 22 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Empathogen 9.6
    Extreme 10/10

    Strong euphoria, stimulation, sensory enhancement, and empathy

    Empathy / Social Openness ×3
    9
    empathy enhancement increased sociability
    Euphoria / Mood Elevation ×2
    10
    euphoria mood lift
    Stimulation ×1
    10
    stimulation teeth grinding
    Sensory Enhancement ×1
    10
    tactile enhancement music enhancement increased libido
    Stimulant 6.8
    Strong+ 7/10

    Strong euphoria, anxiety/jitters, and stimulation with mild focus

    Stimulation / Energy ×3
    8
    stimulation
    Euphoria / Mood Lift ×2
    10
    euphoria mood lift motivation enhancement
    Focus / Productivity ×2
    5
    motivation enhancement
    ⚠ Anxiety / Jitters ×1
    10
    anxiety teeth grinding bruxism sweating
    Based on reports from:
    Erowid Experience Reports PsychonautWiki 4-MEC
    View methodology →

    Tolerance

    Build-up develops rapidly, often within a single session; compulsive redosing common
    Reset a few days for acute tolerance

    Tolerance Decay

    Full tolerance 1d Half tolerance 7d Baseline ~21d

    Acute tolerance within a session is common; users report markedly diminished returns after initial doses and stronger comedowns with binges. Conservative spacing (≥2 weeks) is commonly advised in HR communities to limit cumulative harms; empirical pharmacodynamic tolerance half-life is not well established.

    Cross-Tolerances

    Other cathinones (e.g., 3‑MMC, 4‑MMC)
    60%
    MDMA
    40%

    Effects Erowid

    Aggregated from 22 Erowid experience reports

    Positive Effects 8

    Euphoria 81.8% 70%
    Stimulation 72.7% 70%
    Music Enhancement 50.0% 70%
    Tactile Enhancement 40.9% 70%
    Empathy 31.8% 70%
    Focus Enhancement 22.7% 70%
    Color Enhancement 18.2% 70%
    Introspection 18.2% 70%

    Adverse Effects 8

    Nausea 40.9% 70%
    Anxiety 36.4% 70%
    Increased Heart Rate 31.8% 70%
    Sweating 27.3% 70%
    Headache 22.7% 70%
    Pupil Dilation 22.7% 70%
    Jaw Clenching 13.6% 70%
    Confusion 13.6% 70%

    Combinations TripSit

    4-MEC's nerd page Pharmacology, chemical data, effect profiles, and more
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    Helpful Links

    📘 Experience Reports 📖 TheDrug.Wiki 📖 PsychonautWiki